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Trait

Depressed nasal tip

Decreased distance from the nasal tip to the nasal base.

HPO HP:0000437

Summary

Also called
Caved in nasal tip, Depressed tip of nose, Flat nasal tip, Flat tip of nose, Flattened nasal tip, Nasal tip, depressed, Nasal tip, recessed, Nasal tip, retruded, Retruded tip of nose
Body system
Abnormality of head or neck

29 genes linked to Depressed nasal tip

Changes in these genes cause rare conditions in which Depressed nasal tip is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
TGIF1TGFB induced factor homeobox 1AlwaysIn 1 condition
UBAP2Lubiquitin associated protein 2 likeAlwaysIn 1 condition
ACTBactin betaVery often (80–99%)In 1 condition
ACTG1actin gamma 1Very often (80–99%)In 1 condition
ALX4ALX homeobox 4Very often (80–99%)In 2 conditions
EXT2exostosin glycosyltransferase 2Very often (80–99%)In 1 condition
KMT2Alysine methyltransferase 2AVery often (80–99%)In 1 condition
PHF21APHD finger protein 21AVery often (80–99%)In 1 condition
POGZpogo transposable element derived with ZNF domainVery often (80–99%)In 1 condition
EPG5ectopic P-granules 5 autophagy tethering factorOften (30–79%)In 1 condition
EXOC2exocyst complex component 2Often (30–79%)In 1 condition
FANCLFA complementation group LOften (30–79%)In 1 condition
FLNAfilamin AOften (30–79%)In 2 conditions
KDM6Alysine demethylase 6AOften (30–79%)In 3 conditions
KMT2Dlysine methyltransferase 2DOften (30–79%)In 2 conditions
RBSNrabenosyn, RAB effectorOften (30–79%)In 1 condition
ZEB2zinc finger E-box binding homeobox 2Often (30–79%)In 2 conditions
NAA10N-alpha-acetyltransferase 10, NatA catalytic subunitSometimes (5–29%)In 1 condition
PRIM1DNA primase subunit 1Sometimes (5–29%)In 1 condition
PTCH1patched 1Sometimes (5–29%)In 1 condition
TBX2T-box transcription factor 2Sometimes (5–29%)In 1 condition
SPTBN1spectrin beta, non-erythrocytic 1Rarely (1–4%)In 1 condition
CILK1ciliogenesis associated kinase 1Not recordedIn 1 condition
COLEC11collectin subfamily member 11Not recordedIn 1 condition
EIF2S3eukaryotic translation initiation factor 2 subunit gammaNot recordedIn 1 condition
MUSKmuscle associated receptor tyrosine kinaseNot recordedIn 1 condition
MYCNMYCN proto-oncogene, bHLH transcription factorNot recordedIn 1 condition
TAF1TATA-box binding protein associated factor 1Not recordedIn 1 condition
TP63tumor protein p63Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the nasal tip

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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