Trait
Bunion
Clinical name: Hallux valgus
Lateral deviation of the great toe (i.e., in the direction of the little toe).
Summary
- Also called
- Lateral deviation of great toe, Lateral deviation of halluces
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Changes in these genes cause rare conditions in which Bunion is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACVR1activin A receptor type 1 | Always | In 2 conditions |
| AEBP1AE binding protein 1 | Always | In 2 conditions |
| ALPK3alpha kinase 3 | Always | In 1 condition |
| COL1A1collagen type I alpha 1 chain | Always | In 2 conditions |
| DONSONDNA replication fork stabilization factor DONSON | Always | In 1 condition |
| ERFETS2 repressor factor | Always | In 1 condition |
| FHL1four and a half LIM domains 1 | Always | In 1 condition |
| GNPNAT1glucosamine-phosphate N-acetyltransferase 1 | Always | In 1 condition |
| HOXA13homeobox A13 | Always | In 1 condition |
| IL11RAinterleukin 11 receptor subunit alpha | Always | In 1 condition |
| ITCHitchy E3 ubiquitin protein ligase | Always | In 1 condition |
| MSL2MSL complex subunit 2 | Always | In 1 condition |
| NONOnon-POU domain containing octamer binding | Always | In 2 conditions |
| PYCR1pyrroline-5-carboxylate reductase 1 | Always | In 1 condition |
| SCARF2scavenger receptor class F member 2 | Always | In 2 conditions |
| SPTAN1spectrin alpha, non-erythrocytic 1 | Always | In 1 condition |
| TWIST1twist family bHLH transcription factor 1 | Always | In 3 conditions |
| ATL3atlastin GTPase 3 | Very often (80–99%) | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Very often (80–99%) | In 2 conditions |
| B3GALT6beta-1,3-galactosyltransferase 6 | Often (30–79%) | In 2 conditions |
| B3GAT3beta-1,3-glucuronyltransferase 3 | Often (30–79%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Often (30–79%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Often (30–79%) | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Often (30–79%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Often (30–79%) | In 1 condition |
| COL1A2collagen type I alpha 2 chain | Often (30–79%) | In 3 conditions |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Often (30–79%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Often (30–79%) | In 1 condition |
| ELNelastin | Often (30–79%) | In 2 conditions |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Often (30–79%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Often (30–79%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Often (30–79%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Often (30–79%) | In 1 condition |
| H4C9H4 clustered histone 9 | Often (30–79%) | In 1 condition |
| HEATR3HEAT repeat containing 3 | Often (30–79%) | In 1 condition |
| HOXD13homeobox D13 | Often (30–79%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Often (30–79%) | In 1 condition |
| METTL27methyltransferase like 27 | Often (30–79%) | In 1 condition |
| MLXIPLMLX interacting protein like | Often (30–79%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Often (30–79%) | In 1 condition |
Show 46 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NFIXnuclear factor I X | Often (30–79%) | In 1 condition |
| RFC2replication factor C subunit 2 | Often (30–79%) | In 1 condition |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Often (30–79%) | In 1 condition |
| STX1Asyntaxin 1A | Often (30–79%) | In 1 condition |
| TBL2transducin beta like 2 | Often (30–79%) | In 1 condition |
| TMEM270transmembrane protein 270 | Often (30–79%) | In 1 condition |
| TNXBtenascin XB | Often (30–79%) | In 1 condition |
| TTI2TELO2 interacting protein 2 | Often (30–79%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Often (30–79%) | In 1 condition |
| ZNF668zinc finger protein 668 | Often (30–79%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Sometimes (5–29%) | In 1 condition |
| ATP6V1B2ATPase H+ transporting V1 subunit B2 | Sometimes (5–29%) | In 1 condition |
| CDKL5cyclin dependent kinase like 5 | Sometimes (5–29%) | In 1 condition |
| CWC27CWC27 spliceosome associated cyclophilin | Sometimes (5–29%) | In 2 conditions |
| DYRK1Adual specificity tyrosine phosphorylation regulated kinase 1A | Sometimes (5–29%) | In 2 conditions |
| ERMARDER membrane associated RNA degradation | Sometimes (5–29%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Sometimes (5–29%) | In 2 conditions |
| FGFR3fibroblast growth factor receptor 3 | Sometimes (5–29%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Sometimes (5–29%) | In 1 condition |
| KCNH1potassium voltage-gated channel subfamily H member 1 | Sometimes (5–29%) | In 1 condition |
| KCNN3potassium calcium-activated channel subfamily N member 3 | Sometimes (5–29%) | In 1 condition |
| KDM5Alysine demethylase 5A | Sometimes (5–29%) | In 1 condition |
| NUP107nucleoporin 107 | Sometimes (5–29%) | In 1 condition |
| PCDHGC4protocadherin gamma subfamily C, 4 | Sometimes (5–29%) | In 1 condition |
| PRDM5PR/SET domain 5 | Sometimes (5–29%) | In 1 condition |
| PSMB8proteasome 20S subunit beta 8 | Sometimes (5–29%) | In 1 condition |
| SCAF4SR-related CTD associated factor 4 | Sometimes (5–29%) | In 1 condition |
| SF3B4splicing factor 3b subunit 4 | Sometimes (5–29%) | In 1 condition |
| SOX9SRY-box transcription factor 9 | Sometimes (5–29%) | In 1 condition |
| SRYsex determining region Y | Sometimes (5–29%) | In 1 condition |
| TCF12transcription factor 12 | Sometimes (5–29%) | In 1 condition |
| USP7ubiquitin specific peptidase 7 | Sometimes (5–29%) | In 1 condition |
| USP9Xubiquitin specific peptidase 9 X-linked | Sometimes (5–29%) | In 1 condition |
| YY1YY1 transcription factor | Sometimes (5–29%) | In 2 conditions |
| ZEB2zinc finger E-box binding homeobox 2 | Sometimes (5–29%) | In 2 conditions |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| ZNF469zinc finger protein 469 | Sometimes (5–29%) | In 1 condition |
| EHMT1euchromatic histone lysine methyltransferase 1 | Rarely (1–4%) | In 1 condition |
| BMP2bone morphogenetic protein 2 | Not recorded | In 1 condition |
| BMPR1Bbone morphogenetic protein receptor type 1B | Not recorded | In 1 condition |
| GDF5growth differentiation factor 5 | Not recorded | In 1 condition |
| MYH3myosin heavy chain 3 | Not recorded | In 1 condition |
| RBBP8RB binding protein 8, endonuclease | Not recorded | In 1 condition |
| SLC16A2solute carrier family 16 member 2 | Not recorded | In 1 condition |
| TP63tumor protein p63 | Not recorded | In 1 condition |
| ZMIZ1zinc finger MIZ-type containing 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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