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Trait

Amniotic constriction ring

Annular constrictions around the digits, limbs, or trunk, occurring congenitally (sometimes causing intrauterine autoamputation) and also associated with a wide variety of disorders. Constrictive amniotic bands are the result of primary amniotic rupture, which can lead to entanglement of fetal tissue (especially limbs) in fibrous amniotic strands.

HPO HP:0009775

Summary

Also called
Amniotic bands, Congenital constriction band sequence, Pseudoainhum
Body system
Abnormality of prenatal development or birth

10 condition reports read genes linked to this trait

Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.

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21 genes linked to Amniotic constriction ring

Changes in these genes cause rare conditions in which Amniotic constriction ring is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
LORICRINloricrin cornified envelope precursor proteinAlwaysIn 1 condition
GJB2gap junction protein beta 2Very often (80–99%)In 2 conditions
GLE1GLE1 RNA export mediatorOften (30–79%)In 1 condition
KRT1keratin 1Often (30–79%)In 1 condition
TRPV3transient receptor potential cation channel subfamily V member 3Often (30–79%)In 1 condition
ABCA12ATP binding cassette subfamily A member 12Sometimes (5–29%)In 1 condition
ALOX12Barachidonate 12-lipoxygenase, 12R typeSometimes (5–29%)In 1 condition
ALOXE3arachidonate epidermal lipoxygenase 3Sometimes (5–29%)In 1 condition
ASPRV1aspartic peptidase retroviral like 1Sometimes (5–29%)In 1 condition
CYP4F22cytochrome P450 family 4 subfamily F member 22Sometimes (5–29%)In 1 condition
LIPNlipase family member NSometimes (5–29%)In 1 condition
NIPAL4NIPA like domain containing 4Sometimes (5–29%)In 1 condition
SDR9C7short chain dehydrogenase/reductase family 9C member 7Sometimes (5–29%)In 1 condition
SMARCAD1SNF2 related chromatin remodeling ATPase with DExD box 1Sometimes (5–29%)In 1 condition
SULT2B1sulfotransferase family 2B member 1Sometimes (5–29%)In 1 condition
TGM1transglutaminase 1Sometimes (5–29%)In 1 condition
TP63tumor protein p63Sometimes (5–29%)In 1 condition
COL3A1collagen type III alpha 1 chainRarely (1–4%)In 1 condition
FERMT1FERM domain containing kindlin 1Not recordedIn 1 condition
KANK2KN motif and ankyrin repeat domains 2Not recordedIn 1 condition
POMPproteasome maturation proteinNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal placental membrane morphology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.19-9814e911.

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