Trait
Increased nail curvature
Clinical name: Hyperconvex nail
When viewed on end (with the digit tip pointing toward the examiner's eye) the curve of the nail forms a tighter curve of convexity.
Summary
- Also called
- Nail overcurvature
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Get my Genome Test14 genes linked to Increased nail curvature
Changes in these genes cause rare conditions in which Increased nail curvature is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ECE1endothelin converting enzyme 1 | Always | In 1 condition |
| GINS3GINS complex subunit 3 | Always | In 1 condition |
| GTPBP2GTP binding protein 2 | Always | In 1 condition |
| POMPproteasome maturation protein | Always | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Often (30–79%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Often (30–79%) | In 1 condition |
| H3-3BH3.3 histone B | Sometimes (5–29%) | In 1 condition |
| SIN3ASIN3 transcription regulator family member A | Sometimes (5–29%) | In 1 condition |
| TCF4transcription factor 4 | Sometimes (5–29%) | In 1 condition |
| ARXaristaless related homeobox | Not recorded | In 1 condition |
| ORC1origin recognition complex subunit 1 | Not recorded | In 1 condition |
| PIGVphosphatidylinositol glycan anchor biosynthesis class V | Not recorded | In 1 condition |
| SETBP1SET binding protein 1 | Not recorded | In 1 condition |
| TP63tumor protein p63 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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