AtlasWho We HelpOur ScienceProductsOutcomes
Log InAskSequence your genome↗
Trait
Narrow opening between the eyelids
Clinical name: Blepharophimosis
A fixed reduction in the vertical distance between the upper and lower eyelids with short palpebral fissures.
Summary
- Also called
- Decreased width of palpebral fissure
- Body system
- Abnormality of head or neck
AtlasWho We HelpOur ScienceProductsOutcomes
Log InAskSequence your genome↗
This page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/traits/blepharophimosis.json"
page <- fromJSON(url)
page$trait$nameNarrow opening between the eyelidsHP:0000581
AtlasWho We HelpOur ScienceProductsOutcomes
Log InAskSequence your genome↗
Read the genes linked to Narrow opening between the eyelids, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test46 condition reports read genes linked to this trait
Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.
- Intellectual DisabilityReads 21 of these genesHNRNPH1MED12SMARCA2MECP2CREBBPCUL4BAbout this report →
- Cutis LaxaReads 5 of these genesATP6V1E1ELNATP6V1AEMILIN1SLC2A10About this report →
- 22q11.2 Deletion SyndromeReads 1 of these genesTBX1About this report →
- Rett Syndrome and MECP2-Related DisordersReads 1 of these genesMECP2About this report →
Show 42 more reports
- DNA Repair DiseaseReads 5 of these genesERCC1SLX4FANCD2BRCA1ERCC6About this report →
- Microphthalmia, Anophthalmia & ColobomaReads 4 of these genesERCC1STRA6BCORRAB18About this report →
- Congenital Cranial Dysinnervation DisordersReads 2 of these genesCHN1MAFBAbout this report →
- Fanconi AnemiaReads 3 of these genesSLX4FANCD2BRCA1About this report →
- Hereditary Breast and Ovarian Cancer (BRCA1/2)Reads 1 of these genesBRCA1About this report →
- Juvenile Polyposis SyndromeReads 1 of these genesSMAD4About this report →
- Syndromic CraniosynostosisReads 3 of these genesRECQL4SMOWDR35About this report →
- EBV-Driven Lymphoproliferation and CARD11 Immune DysregulationReads 1 of these genesIKZF2About this report →
- Familial Periodic ParalysisReads 1 of these genesKCNJ2About this report →
- Monogenic Precocious PubertyReads 1 of these genesDLK1About this report →
- Rothmund-Thomson SyndromeReads 1 of these genesRECQL4About this report →
- Familial Atrial FibrillationReads 1 of these genesKCNJ2About this report →
- Hereditary Hemorrhagic TelangiectasiaReads 1 of these genesSMAD4About this report →
- Overgrowth Syndromes (Sotos, Weaver, Tatton-Brown-Rahman, Malan)Reads 1 of these genesDNMT3AAbout this report →
- Short Qt SyndromeReads 1 of these genesKCNJ2About this report →
- Mosaic Variegated Aneuploidy SyndromeReads 1 of these genesCEP57About this report →
- Noonan SyndromeReads 2 of these genesKRASMAPK1About this report →
- Chronic Granulomatous DiseaseReads 1 of these genesNCF1About this report →
- Hereditary SpherocytosisReads 1 of these genesANK1About this report →
- Congenital Myasthenic SyndromeReads 2 of these genesALG14MUSKAbout this report →
- Autoimmune Lymphoproliferative Syndrome (ALPS)Reads 1 of these genesKRASAbout this report →
- Ellis-van Creveld Syndrome and Cranioectodermal DysplasiaReads 1 of these genesWDR35About this report →
- Waardenburg SyndromeReads 1 of these genesPAX3About this report →
- Epilepsy (Full Panel)Reads 5 of these genesMECP2ATP6V1AFOXG1SLC6A1UGDHAbout this report →
- Other Inborn Errors of ImmunityReads 5 of these genesIKZF2NCF1RELKRASTBX1About this report →
- Long QT SyndromeReads 1 of these genesKCNJ2About this report →
- LipodystrophyReads 1 of these genesZMPSTE24About this report →
- Inherited Congenital Heart DefectsReads 1 of these genesELNAbout this report →
- Female InfertilityReads 2 of these genesFOXL2TP63About this report →
- Hypertrophic CardiomyopathyReads 2 of these genesKRASMAPK1About this report →
- Primary Lymphoedema & Lymphatic MalformationsReads 1 of these genesFAT4About this report →
- Ectodermal DysplasiasReads 1 of these genesTP63About this report →
- 46,XY Differences of Sex Development and Gonadal DysgenesisReads 1 of these genesHHATAbout this report →
- Autoimmune DiseaseReads 1 of these genesKRASAbout this report →
- Congenital Disorders of GlycosylationReads 2 of these genesALG14MOGSAbout this report →
- Non-Acquired Combined Pituitary Hormone DeficiencyReads 1 of these genesSMOAbout this report →
- Spinal Muscular AtrophyReads 1 of these genesEMILIN1About this report →
- Hereditary Palmoplantar Keratodermas and Pachyonychia CongenitaReads 1 of these genesGJA1About this report →
- Male InfertilityReads 1 of these genesFKBP6About this report →
- Charcot-Marie-Tooth DiseaseReads 1 of these genesEMILIN1About this report →
- Hearing Loss and DeafnessReads 1 of these genesIKZF2About this report →
- Primary Mitochondrial DiseaseReads 1 of these genesDNAJC30About this report →
Read the genes linked to Narrow opening between the eyelids, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test138 genes linked to Narrow opening between the eyelids
Changes in these genes cause rare conditions in which Narrow opening between the eyelids is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALX4ALX homeobox 4 | Always | In 1 condition |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Always | In 1 condition |
| CEP57centrosomal protein 57 | Always | In 1 condition |
| ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit | Always | In 1 condition |
| FOXL2forkhead box L2 | Always | In 2 conditions |
| HNRNPH1heterogeneous nuclear ribonucleoprotein H1 | Always | In 1 condition |
| IKZF2IKAROS family zinc finger 2 | Always | In 1 condition |
| IRX5iroquois homeobox 5 | Always | In 1 condition |
| MED12mediator complex subunit 12 | Always | In 2 conditions |
| PRIM1DNA primase subunit 1 | Always | In 1 condition |
| RBMXRNA binding motif protein X-linked | Always | In 2 conditions |
| RBSNrabenosyn, RAB effector | Always | In 1 condition |
| SCARF2scavenger receptor class F member 2 | Always | In 2 conditions |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Always | In 2 conditions |
| UBE3Bubiquitin protein ligase E3B | Always | In 2 conditions |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Very often (80–99%) | In 1 condition |
| BCL11ABCL11 transcription factor A | Very often (80–99%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Very often (80–99%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Very often (80–99%) | In 1 condition |
| COLEC10collectin subfamily member 10 | Very often (80–99%) | In 2 conditions |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Very often (80–99%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Very often (80–99%) | In 1 condition |
| ELNelastin | Very often (80–99%) | In 2 conditions |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Very often (80–99%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Very often (80–99%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Very often (80–99%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Very often (80–99%) | In 1 condition |
| KAT6Blysine acetyltransferase 6B | Very often (80–99%) | In 2 conditions |
| LIMK1LIM domain kinase 1 | Very often (80–99%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Very often (80–99%) | In 1 condition |
| METTL27methyltransferase like 27 | Very often (80–99%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Very often (80–99%) | In 1 condition |
| PAX3paired box 3 | Very often (80–99%) | In 4 conditions |
| PIEZO2piezo type mechanosensitive ion channel component 2 | Very often (80–99%) | In 3 conditions |
| RELREL proto-oncogene, NF-kB subunit | Very often (80–99%) | In 1 condition |
| RFC2replication factor C subunit 2 | Very often (80–99%) | In 1 condition |
| SMOC1SPARC related modular calcium binding 1 | Very often (80–99%) | In 2 conditions |
| STX1Asyntaxin 1A | Very often (80–99%) | In 1 condition |
| TBL2transducin beta like 2 | Very often (80–99%) | In 1 condition |
| TMEM270transmembrane protein 270 | Very often (80–99%) | In 1 condition |
Show 98 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| VPS37DVPS37D subunit of ESCRT-I | Very often (80–99%) | In 1 condition |
| XPO1exportin 1 | Very often (80–99%) | In 1 condition |
| ALG14ALG14 UDP-N-acetylglucosaminyltransferase subunit | Often (30–79%) | In 1 condition |
| ATP6V1AATPase H+ transporting V1 subunit A | Often (30–79%) | In 1 condition |
| CEP152centrosomal protein 152 | Often (30–79%) | In 1 condition |
| CHN1chimerin 1 | Often (30–79%) | In 1 condition |
| COLEC11collectin subfamily member 11 | Often (30–79%) | In 2 conditions |
| CREBBPCREB binding lysine acetyltransferase | Often (30–79%) | In 1 condition |
| CUL4Bcullin 4B | Often (30–79%) | In 1 condition |
| EP300EP300 lysine acetyltransferase | Often (30–79%) | In 1 condition |
| FAT4FAT atypical cadherin 4 | Often (30–79%) | In 3 conditions |
| FOXG1forkhead box G1 | Often (30–79%) | In 1 condition |
| HHAThedgehog acyltransferase | Often (30–79%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Often (30–79%) | In 2 conditions |
| HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 | Often (30–79%) | In 1 condition |
| KANSL1KAT8 regulatory NSL complex subunit 1 | Often (30–79%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| MAFBMAF bZIP transcription factor B | Often (30–79%) | In 1 condition |
| MASP1MBL associated serine protease 1 | Often (30–79%) | In 2 conditions |
| MCTP2multiple C2 and transmembrane domain containing 2 | Often (30–79%) | In 1 condition |
| MLXIPLMLX interacting protein like | Often (30–79%) | In 1 condition |
| PHF6PHD finger protein 6 | Often (30–79%) | In 2 conditions |
| RIPK4receptor interacting serine/threonine kinase 4 | Often (30–79%) | In 1 condition |
| SALL4spalt like transcription factor 4 | Often (30–79%) | In 1 condition |
| SMAD4SMAD family member 4 | Often (30–79%) | In 2 conditions |
| STRA6signaling receptor and transporter of retinol STRA6 | Often (30–79%) | In 1 condition |
| TBX15T-box transcription factor 15 | Often (30–79%) | In 2 conditions |
| TLK2tousled like kinase 2 | Often (30–79%) | In 1 condition |
| TRAF7TNF receptor associated factor 7 | Often (30–79%) | In 1 condition |
| TUBBtubulin beta class I | Often (30–79%) | In 1 condition |
| ANK1ankyrin 1 | Sometimes (5–29%) | In 1 condition |
| ATXN7L3ataxin 7 like 3 | Sometimes (5–29%) | In 1 condition |
| BCRBCR activator of RhoGEF and GTPase | Sometimes (5–29%) | In 1 condition |
| BRPF1bromodomain and PHD finger containing 1 | Sometimes (5–29%) | In 1 condition |
| CDK13cyclin dependent kinase 13 | Sometimes (5–29%) | In 1 condition |
| CRKLCRK like proto-oncogene, adaptor protein | Sometimes (5–29%) | In 1 condition |
| DACT1dishevelled binding antagonist of beta catenin 1 | Sometimes (5–29%) | In 1 condition |
| DCHS1dachsous cadherin-related 1 | Sometimes (5–29%) | In 2 conditions |
| DLK1delta like non-canonical Notch ligand 1 | Sometimes (5–29%) | In 1 condition |
| DOT1LDOT1 like histone lysine methyltransferase | Sometimes (5–29%) | In 1 condition |
| EMILIN1elastin microfibril interfacer 1 | Sometimes (5–29%) | In 1 condition |
| FOXP1forkhead box P1 | Sometimes (5–29%) | In 1 condition |
| GPKOWG-patch domain and KOW motifs | Sometimes (5–29%) | In 1 condition |
| KCTD1potassium channel tetramerization domain containing 1 | Sometimes (5–29%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Sometimes (5–29%) | In 1 condition |
| MAPRE2microtubule associated protein RP/EB family member 2 | Sometimes (5–29%) | In 1 condition |
| MEG3maternally expressed 3 | Sometimes (5–29%) | In 1 condition |
| MYL11myosin light chain 11 | Sometimes (5–29%) | In 1 condition |
| NSUN2NOP2/Sun RNA methyltransferase 2 | Sometimes (5–29%) | In 1 condition |
| ODC1ornithine decarboxylase 1 | Sometimes (5–29%) | In 2 conditions |
| REREarginine-glutamic acid dipeptide repeats | Sometimes (5–29%) | In 2 conditions |
| RNU4-2RNA, U4 small nuclear 2 | Sometimes (5–29%) | In 1 condition |
| RTL1retrotransposon Gag like 1 | Sometimes (5–29%) | In 1 condition |
| SALL1spalt like transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| SETD5SET domain containing 5 | Sometimes (5–29%) | In 1 condition |
| SLC2A10solute carrier family 2 member 10 | Sometimes (5–29%) | In 2 conditions |
| SLC6A1solute carrier family 6 member 1 | Sometimes (5–29%) | In 1 condition |
| SLC6A11solute carrier family 6 member 11 | Sometimes (5–29%) | In 1 condition |
| SLX4SLX4 structure-specific endonuclease subunit | Sometimes (5–29%) | In 1 condition |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| CTCFCCCTC-binding factor | Rarely (1–4%) | In 1 condition |
| FANCD2FA complementation group D2 | Rarely (1–4%) | In 1 condition |
| ATRATR checkpoint kinase | Not recorded | In 1 condition |
| BCORBCL6 corepressor | Not recorded | In 1 condition |
| BRCA1BRCA1 DNA repair associated | Not recorded | In 1 condition |
| DDR2discoidin domain receptor tyrosine kinase 2 | Not recorded | In 1 condition |
| DGCR2DiGeorge syndrome critical region gene 2 | Not recorded | In 1 condition |
| DGCR6DiGeorge syndrome critical region gene 6 | Not recorded | In 1 condition |
| DGCR8DGCR8 microprocessor complex subunit | Not recorded | In 1 condition |
| DNMT3ADNA methyltransferase 3 alpha | Not recorded | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Not recorded | In 1 condition |
| ESS2ess-2 spliceosome associated protein | Not recorded | In 1 condition |
| GATAD2BGATA zinc finger domain containing 2B | Not recorded | In 1 condition |
| GJA1gap junction protein alpha 1 | Not recorded | In 1 condition |
| GPC6glypican 6 | Not recorded | In 1 condition |
| HDAC4histone deacetylase 4 | Not recorded | In 1 condition |
| KCNJ2potassium inwardly rectifying channel subfamily J member 2 | Not recorded | In 1 condition |
| KMT2Alysine methyltransferase 2A | Not recorded | In 1 condition |
| MOGSmannosyl-oligosaccharide glucosidase | Not recorded | In 1 condition |
| MUSKmuscle associated receptor tyrosine kinase | Not recorded | In 1 condition |
| MYCNMYCN proto-oncogene, bHLH transcription factor | Not recorded | In 1 condition |
| MYH3myosin heavy chain 3 | Not recorded | In 1 condition |
| NFIBnuclear factor I B | Not recorded | In 1 condition |
| ORC1origin recognition complex subunit 1 | Not recorded | In 1 condition |
| RAB18RAB18, member RAS oncogene family | Not recorded | In 1 condition |
| RECQL4RecQ like helicase 4 | Not recorded | In 1 condition |
| SEPTIN9septin 9 | Not recorded | In 1 condition |
| SF3B2splicing factor 3b subunit 2 | Not recorded | In 1 condition |
| SMOsmoothened, frizzled class receptor | Not recorded | In 1 condition |
| SOX9SRY-box transcription factor 9 | Not recorded | In 1 condition |
| STAC3SH3 and cysteine rich domain 3 | Not recorded | In 1 condition |
| TBL1XR1TBL1X/Y related 1 | Not recorded | In 1 condition |
| TBX1T-box transcription factor 1 | Not recorded | In 2 conditions |
| TP63tumor protein p63 | Not recorded | In 1 condition |
| TXNL4Athioredoxin like 4A | Not recorded | In 1 condition |
| UGDHUDP-glucose 6-dehydrogenase | Not recorded | In 1 condition |
| WDR35WD repeat domain 35 | Not recorded | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.17-8666dff2.
AtlasWho We HelpOur ScienceProductsOutcomes
Log InAskSequence your genome↗
From traits to your genome
Read the genes behind these traits in your own DNA.
The Genome Test sequences nearly all of your DNA, not a preset panel, so every gene on these pages is in your data. Premium adds 470+ physician-ready reports.
From $449
Free shipping · Results in 6–8 weeks
