Trait
Low self-esteem
Persistent, excessively negative, and critical thoughts of one's personal abilities, attributes, or any feature related to the self and self-attitude. The affected individual believes they are a lesser being compared to others in their social peer group.
Summary
- Also called
- Worthlessness
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test11 genes linked to Low self-esteem
Changes in these genes cause rare conditions in which Low self-esteem is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FMO3flavin containing dimethylaniline monoxygenase 3 | Often (30–79%) | In 1 condition |
| CACNA1Hcalcium voltage-gated channel subunit alpha1 H | Sometimes (5–29%) | In 1 condition |
| GABRA1gamma-aminobutyric acid type A receptor subunit alpha1 | Sometimes (5–29%) | In 1 condition |
| GABRB3gamma-aminobutyric acid type A receptor subunit beta3 | Sometimes (5–29%) | In 1 condition |
| GABRG2gamma-aminobutyric acid type A receptor subunit gamma2 | Sometimes (5–29%) | In 1 condition |
| IRF6interferon regulatory factor 6 | Sometimes (5–29%) | In 1 condition |
| JRKJrk helix-turn-helix protein | Sometimes (5–29%) | In 1 condition |
| MSX1msh homeobox 1 | Sometimes (5–29%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Sometimes (5–29%) | In 1 condition |
| TAF11TATA-box binding protein associated factor 11 | Sometimes (5–29%) | In 1 condition |
| TP63tumor protein p63 | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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