Trait
Abnormality of dental shape
Clinical name: Abnormal dental morphology
An abnormality of the morphology of the tooth.
Summary
- Also called
- Abnormally shaped teeth, Deformity of teeth, Dental deformity, Dental malformations, Malformed teeth, Misshapen teeth, Misshapened teeth, Abnormality of dental morphology, Abnormality of shape of tooth, Malformation of teeth
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Abnormality of dental shape, and the rest of your genome, with one test.
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Get my Genome Test70 genes linked to Abnormality of dental shape
Changes in these genes cause rare conditions in which Abnormality of dental shape is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3 | Very often (80–99%) | In 1 condition |
| ANTXR2ANTXR cell adhesion molecule 2 | Very often (80–99%) | In 1 condition |
| CCBE1collagen and calcium binding EGF domains 1 | Very often (80–99%) | In 1 condition |
| CDH3cadherin 3 | Very often (80–99%) | In 1 condition |
| DHCR77-dehydrocholesterol reductase | Very often (80–99%) | In 1 condition |
| EDARectodysplasin A receptor | Very often (80–99%) | In 2 conditions |
| EDARADDEDAR associated via death domain | Very often (80–99%) | In 3 conditions |
| FAT4FAT atypical cadherin 4 | Very often (80–99%) | In 1 condition |
| KDF1keratinocyte differentiation factor 1 | Very often (80–99%) | In 1 condition |
| LONP1lon peptidase 1, mitochondrial | Very often (80–99%) | In 1 condition |
| LRP6LDL receptor related protein 6 | Very often (80–99%) | In 2 conditions |
| MSX1msh homeobox 1 | Very often (80–99%) | In 2 conditions |
| PIGLphosphatidylinositol glycan anchor biosynthesis class L | Very often (80–99%) | In 1 condition |
| RNU12RNA, U12 small nuclear | Very often (80–99%) | In 1 condition |
| RPS6KA3ribosomal protein S6 kinase A3 | Very often (80–99%) | In 1 condition |
| TRAF6TNF receptor associated factor 6 | Very often (80–99%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Often (30–79%) | In 1 condition |
| BCORBCL6 corepressor | Often (30–79%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Often (30–79%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Often (30–79%) | In 1 condition |
| CSTBcystatin B | Often (30–79%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Often (30–79%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Often (30–79%) | In 1 condition |
| ELNelastin | Often (30–79%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Often (30–79%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Often (30–79%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Often (30–79%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Often (30–79%) | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Often (30–79%) | In 1 condition |
| KDM6Alysine demethylase 6A | Often (30–79%) | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Often (30–79%) | In 1 condition |
| KRT14keratin 14 | Often (30–79%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Often (30–79%) | In 1 condition |
| METTL27methyltransferase like 27 | Often (30–79%) | In 1 condition |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Often (30–79%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Often (30–79%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Often (30–79%) | In 1 condition |
| RFC2replication factor C subunit 2 | Often (30–79%) | In 1 condition |
| SH3BP2SH3 domain binding protein 2 | Often (30–79%) | In 1 condition |
| STX1Asyntaxin 1A | Often (30–79%) | In 1 condition |
Show 30 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| TBL2transducin beta like 2 | Often (30–79%) | In 1 condition |
| TMEM270transmembrane protein 270 | Often (30–79%) | In 1 condition |
| TP63tumor protein p63 | Often (30–79%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Often (30–79%) | In 1 condition |
| WNT10AWnt family member 10A | Often (30–79%) | In 2 conditions |
| EDAectodysplasin A | Sometimes (5–29%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Sometimes (5–29%) | In 1 condition |
| GREM2gremlin 2, DAN family BMP antagonist | Sometimes (5–29%) | In 1 condition |
| IRF6interferon regulatory factor 6 | Sometimes (5–29%) | In 1 condition |
| PAX9paired box 9 | Sometimes (5–29%) | In 1 condition |
| PKP1plakophilin 1 | Sometimes (5–29%) | In 1 condition |
| POLR1BRNA polymerase I subunit B | Sometimes (5–29%) | In 1 condition |
| POLR1CRNA polymerase I and III subunit C | Sometimes (5–29%) | In 1 condition |
| POLR1DRNA polymerase I and III subunit D | Sometimes (5–29%) | In 1 condition |
| RAI1retinoic acid induced 1 | Sometimes (5–29%) | In 1 condition |
| SUMO1small ubiquitin like modifier 1 | Sometimes (5–29%) | In 1 condition |
| TCOF1treacle ribosome biogenesis factor 1 | Sometimes (5–29%) | In 1 condition |
| TGFAtransforming growth factor alpha | Sometimes (5–29%) | In 1 condition |
| WNT10BWnt family member 10B | Sometimes (5–29%) | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Sometimes (5–29%) | In 2 conditions |
| CLCN7Cl-/H+ antiporter 7 | Rarely (1–4%) | In 1 condition |
| PLEKHM1pleckstrin homology and RUN domain containing M1 | Rarely (1–4%) | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Rarely (1–4%) | In 1 condition |
| ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif 10 | Not recorded | In 1 condition |
| CKAP2Lcytoskeleton associated protein 2L | Not recorded | In 1 condition |
| FBN1fibrillin 1 | Not recorded | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Not recorded | In 1 condition |
| SATB1SATB homeobox 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Decreased size of tooth177 genes
- Cone shaped tooth29 genes
- Abnormal dental position28 genes
- Increased size of tooth21 genes
- Abnormality of canine16 genes
- Irregular teeth6 genes
- Abnormality of baby teeth4 genes
- Abnormality of tooth part2 genes
- Fragile teeth2 genes
- Abnormal shape of molar tooth1 gene
- Abnormality of the dental root1 gene
- Excessive wear and tear on teeth1 gene
- Abnormal number of teeth
- Abnormality of shape of incisor
- Abnormality of shape of premolar
- Double tooth
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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