Trait
Eyelid folded in
Clinical name: Entropion
An abnormal inversion (turning inward) of the eyelid (usually the lower) towards the globe. Entropion is usually acquired as a result of involutional or cicatricial processes but may occasionally be congenital.
Summary
- Also called
- Eyelid turned in, Inverted eyelid
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
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Get my Genome Test31 genes linked to Eyelid folded in
Changes in these genes cause rare conditions in which Eyelid folded in is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Always | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 1 condition |
| POLR3ARNA polymerase III subunit A | Very often (80–99%) | In 2 conditions |
| ZMPSTE24zinc metallopeptidase STE24 | Very often (80–99%) | In 2 conditions |
| ALDH1A3aldehyde dehydrogenase 1 family member A3 | Often (30–79%) | In 1 condition |
| ATP6V1AATPase H+ transporting V1 subunit A | Often (30–79%) | In 1 condition |
| LRRC8Cleucine rich repeat containing 8 VRAC subunit C | Often (30–79%) | In 1 condition |
| DDB2damage specific DNA binding protein 2 | Sometimes (5–29%) | In 2 conditions |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 2 conditions |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Sometimes (5–29%) | In 1 condition |
| ERCC5ERCC excision repair 5, endonuclease | Sometimes (5–29%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 1 condition |
| IKZF1IKAROS family zinc finger 1 | Sometimes (5–29%) | In 1 condition |
| SEPHS1selenophosphate synthetase 1 | Sometimes (5–29%) | In 1 condition |
| TP63tumor protein p63 | Sometimes (5–29%) | In 1 condition |
| XPAXPA, DNA damage recognition and repair factor | Sometimes (5–29%) | In 2 conditions |
| XPCXPC complex subunit, DNA damage recognition and repair factor | Sometimes (5–29%) | In 2 conditions |
| ABCA12ATP binding cassette subfamily A member 12 | Rarely (1–4%) | In 1 condition |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Rarely (1–4%) | In 1 condition |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Rarely (1–4%) | In 1 condition |
| ASPRV1aspartic peptidase retroviral like 1 | Rarely (1–4%) | In 1 condition |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Rarely (1–4%) | In 1 condition |
| LIPNlipase family member N | Rarely (1–4%) | In 1 condition |
| NIPAL4NIPA like domain containing 4 | Rarely (1–4%) | In 1 condition |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Rarely (1–4%) | In 1 condition |
| SULT2B1sulfotransferase family 2B member 1 | Rarely (1–4%) | In 1 condition |
| TGM1transglutaminase 1 | Rarely (1–4%) | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Not recorded | In 1 condition |
| GMNNgeminin DNA replication inhibitor | Not recorded | In 1 condition |
| POLHDNA polymerase eta | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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