Trait
Speech articulation difficulties
Impairment in the physical production of speech sounds.
Summary
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test35 genes linked to Speech articulation difficulties
Changes in these genes cause rare conditions in which Speech articulation difficulties is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| SMAD4SMAD family member 4 | Always | In 1 condition |
| FOXP1forkhead box P1 | Very often (80–99%) | In 1 condition |
| ARHGAP29Rho GTPase activating protein 29 | Often (30–79%) | In 1 condition |
| ARHGEF38Rho guanine nucleotide exchange factor 38 | Often (30–79%) | In 1 condition |
| BMP4bone morphogenetic protein 4 | Often (30–79%) | In 1 condition |
| CDH1cadherin 1 | Often (30–79%) | In 1 condition |
| COBLL1cordon-bleu WH2 repeat protein like 1 | Often (30–79%) | In 1 condition |
| DLG1discs large MAGUK scaffold protein 1 | Often (30–79%) | In 1 condition |
| DLX4distal-less homeobox 4 | Often (30–79%) | In 1 condition |
| GABRG2gamma-aminobutyric acid type A receptor subunit gamma2 | Often (30–79%) | In 1 condition |
| GALTgalactose-1-phosphate uridylyltransferase | Often (30–79%) | In 1 condition |
| GRIN2Aglutamate ionotropic receptor NMDA type subunit 2A | Often (30–79%) | In 3 conditions |
| HTThuntingtin | Often (30–79%) | In 1 condition |
| IRF6interferon regulatory factor 6 | Often (30–79%) | In 3 conditions |
| MAGEL2MAGE family member L2 | Often (30–79%) | In 2 conditions |
| MAPTmicrotubule associated protein tau | Often (30–79%) | In 2 conditions |
| MSX1msh homeobox 1 | Often (30–79%) | In 3 conditions |
| NDNnecdin, MAGE family member | Often (30–79%) | In 2 conditions |
| NECTIN1nectin cell adhesion molecule 1 | Often (30–79%) | In 3 conditions |
| NF1neurofibromin 1 | Often (30–79%) | In 1 condition |
| OCA2OCA2 melanosomal transmembrane protein | Often (30–79%) | In 2 conditions |
| PDGFRAplatelet derived growth factor receptor alpha | Often (30–79%) | In 1 condition |
| RIC1RIC1 partner of RAB6A GEF complex | Often (30–79%) | In 1 condition |
| SH2B1SH2B adaptor protein 1 | Often (30–79%) | In 1 condition |
| SLC2A3solute carrier family 2 member 3 | Often (30–79%) | In 1 condition |
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Often (30–79%) | In 2 conditions |
| SRPX2sushi repeat containing protein X-linked 2 | Often (30–79%) | In 1 condition |
| STAG2STAG2 cohesin complex component | Often (30–79%) | In 1 condition |
| TP63tumor protein p63 | Often (30–79%) | In 3 conditions |
| ALDH4A1aldehyde dehydrogenase 4 family member A1 | Sometimes (5–29%) | In 1 condition |
| GRHL3grainyhead like transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| TAF11TATA-box binding protein associated factor 11 | Sometimes (5–29%) | In 1 condition |
| UBBubiquitin B | Sometimes (5–29%) | In 1 condition |
| GNAI3G protein subunit alpha i3 | Not recorded | In 1 condition |
| PLCB4phospholipase C beta 4 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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