Trait
Increased size of tooth
Clinical name: Macrodontia
Increased size of the teeth, which can be defined as a mesiodistal tooth diameter (width) more than 2 SD above mean for age. Alternatively, an apparently increased maximum width of the tooth.
Summary
- Also called
- Increased width of tooth, Large tooth, Tooth mass excess, Megalodontia
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test21 genes linked to Increased size of tooth
Changes in these genes cause rare conditions in which Increased size of tooth is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ANKRD11ankyrin repeat domain 11 | Always | In 2 conditions |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| PPFIA3PPFI scaffold protein A3 | Always | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Always | In 1 condition |
| ASCC3activating signal cointegrator 1 complex subunit 3 | Often (30–79%) | In 1 condition |
| MGAT2alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | Often (30–79%) | In 1 condition |
| VPS13Bvacuolar protein sorting 13 homolog B | Often (30–79%) | In 1 condition |
| CDK10cyclin dependent kinase 10 | Sometimes (5–29%) | In 1 condition |
| DHX37DEAH-box helicase 37 | Sometimes (5–29%) | In 1 condition |
| GTF3C3general transcription factor IIIC subunit 3 | Sometimes (5–29%) | In 1 condition |
| IRF6interferon regulatory factor 6 | Sometimes (5–29%) | In 1 condition |
| MBD5methyl-CpG binding domain protein 5 | Sometimes (5–29%) | In 1 condition |
| MSX1msh homeobox 1 | Sometimes (5–29%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Sometimes (5–29%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Sometimes (5–29%) | In 1 condition |
| PQBP1polyglutamine binding protein 1 | Sometimes (5–29%) | In 1 condition |
| SMOC1SPARC related modular calcium binding 1 | Sometimes (5–29%) | In 1 condition |
| TAF11TATA-box binding protein associated factor 11 | Sometimes (5–29%) | In 1 condition |
| TP63tumor protein p63 | Sometimes (5–29%) | In 1 condition |
| BRCA1BRCA1 DNA repair associated | Not recorded | In 1 condition |
| VPS51VPS51 subunit of GARP complex | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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