AtlasTrait
Velopharyngeal incompetence
Clinical name: Velopharyngeal insufficiency
Inability of velopharyngeal sphincter to sufficiently separate the nasal cavity from the oral cavity during speech.
Summary
- Body system
- Abnormality of head or neck
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page$trait$nameRead the genes linked to Velopharyngeal incompetence, and the rest of your genome, with one test.
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Get my Genome Test22 condition reports read genes linked to this trait
Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.
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- 22q11.2 Deletion SyndromeReads 1 of these genesTBX1About this report →
- Amyotrophic Lateral Sclerosis Susceptibility 24 (NEK1)Reads 1 of these genesNEK1About this report →
Show 18 more reports
- Beaulieu-Boycott-Innes Syndrome (THOC6)Reads 1 of these genesTHOC6About this report →
- BMP4-Related Microphthalmia and AnophthalmiaReads 1 of these genesBMP4About this report →
- SF3B4-Related Acrofacial Dysostosis (Nager Syndrome)Reads 1 of these genesSF3B4About this report →
- Carey-Fineman-Ziter SyndromeReads 1 of these genesMYMXAbout this report →
- Hereditary Diffuse Gastric CancerReads 1 of these genesCDH1About this report →
- Juvenile Polyposis SyndromeReads 1 of these genesSMAD4About this report →
- Hereditary Gastrointestinal Stromal TumourReads 1 of these genesPDGFRAAbout this report →
- Hereditary Hemorrhagic TelangiectasiaReads 1 of these genesSMAD4About this report →
- Ectodermal DysplasiasReads 2 of these genesNECTIN1TP63About this report →
- Cornelia de Lange SyndromeReads 1 of these genesRAD21About this report →
- Hypodontia and AnodontiaReads 1 of these genesMSX1About this report →
- Breast and Ovarian Cancer Genes Beyond BRCA1/2Reads 1 of these genesCDH1About this report →
- Coffin-Siris SyndromeReads 1 of these genesBICRAAbout this report →
- Syndromic CraniosynostosisReads 1 of these genesTWIST1About this report →
- Intellectual DisabilityReads 3 of these genesRAI1SMAD4RLIMAbout this report →
- Microphthalmia, Anophthalmia & ColobomaReads 1 of these genesBMP4About this report →
- Female InfertilityReads 1 of these genesTP63About this report →
- Other Inborn Errors of ImmunityReads 1 of these genesTBX1About this report →
Read the genes linked to Velopharyngeal incompetence, and the rest of your genome, with one test.
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Get my Genome Test35 genes linked to Velopharyngeal incompetence
Changes in these genes cause rare conditions in which Velopharyngeal incompetence is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DGCR2DiGeorge syndrome critical region gene 2 | Always | In 1 condition |
| DGCR6DiGeorge syndrome critical region gene 6 | Always | In 1 condition |
| DGCR8DGCR8 microprocessor complex subunit | Always | In 1 condition |
| ESS2ess-2 spliceosome associated protein | Always | In 1 condition |
| SF3B4splicing factor 3b subunit 4 | Always | In 1 condition |
| TBX1T-box transcription factor 1 | Always | In 1 condition |
| ARHGAP29Rho GTPase activating protein 29 | Often (30–79%) | In 1 condition |
| ARHGEF38Rho guanine nucleotide exchange factor 38 | Often (30–79%) | In 1 condition |
| BMP4bone morphogenetic protein 4 | Often (30–79%) | In 1 condition |
| CDH1cadherin 1 | Often (30–79%) | In 1 condition |
| COBLL1cordon-bleu WH2 repeat protein like 1 | Often (30–79%) | In 1 condition |
| DLG1discs large MAGUK scaffold protein 1 | Often (30–79%) | In 1 condition |
| DLX4distal-less homeobox 4 | Often (30–79%) | In 1 condition |
| ERI1exoribonuclease 1 | Often (30–79%) | In 1 condition |
| GRHL3grainyhead like transcription factor 3 | Often (30–79%) | In 1 condition |
| IRF6interferon regulatory factor 6 | Often (30–79%) | In 2 conditions |
| MSX1msh homeobox 1 | Often (30–79%) | In 2 conditions |
| MYMXmyomixer, myoblast fusion factor | Often (30–79%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Often (30–79%) | In 2 conditions |
| PDGFRAplatelet derived growth factor receptor alpha | Often (30–79%) | In 1 condition |
| RAD21RAD21 cohesin complex component | Often (30–79%) | In 1 condition |
| RAI1retinoic acid induced 1 | Often (30–79%) | In 2 conditions |
| RIC1RIC1 partner of RAB6A GEF complex | Often (30–79%) | In 1 condition |
| TP63tumor protein p63 | Often (30–79%) | In 3 conditions |
| TWIST1twist family bHLH transcription factor 1 | Often (30–79%) | In 1 condition |
| UBBubiquitin B | Often (30–79%) | In 1 condition |
| BICRABRD4 interacting chromatin remodeling complex associated protein | Sometimes (5–29%) | In 1 condition |
| NEK1NIMA related kinase 1 | Sometimes (5–29%) | In 1 condition |
| SIAH1siah E3 ubiquitin protein ligase 1 | Sometimes (5–29%) | In 1 condition |
| SMAD4SMAD family member 4 | Sometimes (5–29%) | In 1 condition |
| TAF11TATA-box binding protein associated factor 11 | Sometimes (5–29%) | In 1 condition |
| THOC6THO complex subunit 6 | Sometimes (5–29%) | In 2 conditions |
| TWIST2twist family bHLH transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| RLIMring finger protein, LIM domain interacting | Not recorded | In 1 condition |
| TUBB6tubulin beta 6 class V | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.19-9814e911.
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