Trait
Dry skin
Skin characterized by the lack of natural or normal moisture.
Summary
- Also called
- Xerosis
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Dry skin, and the rest of your genome, with one test.
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Get my Genome Test214 genes linked to Dry skin
Changes in these genes cause rare conditions in which Dry skin is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BANF1barrier to autointegration nuclear assembly factor 1 | Always | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Always | In 5 conditions |
| BUD13BUD13 spliceosome associated protein | Always | In 1 condition |
| CILK1ciliogenesis associated kinase 1 | Always | In 1 condition |
| CST6cystatin E/M | Always | In 1 condition |
| DBR1debranching RNA lariats 1 | Always | In 2 conditions |
| EDAectodysplasin A | Always | In 1 condition |
| EDARADDEDAR associated via death domain | Always | In 4 conditions |
| ELOVL1ELOVL fatty acid elongase 1 | Always | In 1 condition |
| ELOVL4ELOVL fatty acid elongase 4 | Always | In 2 conditions |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Always | In 3 conditions |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Always | In 2 conditions |
| FDFT1farnesyl-diphosphate farnesyltransferase 1 | Always | In 1 condition |
| FEM1Bfem-1 homolog B | Always | In 1 condition |
| FLG2filaggrin 2 | Always | In 1 condition |
| GPNMBglycoprotein nmb | Always | In 1 condition |
| GTF2E2general transcription factor IIE subunit 2 | Always | In 2 conditions |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Always | In 1 condition |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Always | In 1 condition |
| NFKBIANFKB inhibitor alpha | Always | In 1 condition |
| PGM2L1phosphoglucomutase 2 like 1 | Always | In 1 condition |
| POLD3DNA polymerase delta 3, accessory subunit | Always | In 1 condition |
| POLR3ARNA polymerase III subunit A | Always | In 1 condition |
| PPP2R3Cprotein phosphatase 2 regulatory subunit B''gamma | Always | In 1 condition |
| RAP1BRAP1B, member of RAS oncogene family | Always | In 1 condition |
| RECQLRecQ like helicase | Always | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Always | In 1 condition |
| RNU6ATACRNA, U6atac small nuclear | Always | In 1 condition |
| SLC39A4solute carrier family 39 member 4 | Always | In 2 conditions |
| SPINK5serine peptidase inhibitor Kazal type 5 | Always | In 2 conditions |
| TGthyroglobulin | Always | In 1 condition |
| TM2D3TM2 domain containing 3 | Always | In 1 condition |
| TP63tumor protein p63 | Always | In 5 conditions |
| TRIP4thyroid hormone receptor interactor 4 | Always | In 2 conditions |
| UBE2Aubiquitin conjugating enzyme E2 A | Always | In 2 conditions |
| WNT10AWnt family member 10A | Always | In 4 conditions |
| YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | Always | In 1 condition |
| ABCA12ATP binding cassette subfamily A member 12 | Very often (80–99%) | In 1 condition |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Very often (80–99%) | In 1 condition |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Very often (80–99%) | In 1 condition |
Show 174 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALOXE3arachidonate epidermal lipoxygenase 3 | Very often (80–99%) | In 1 condition |
| ASPRV1aspartic peptidase retroviral like 1 | Very often (80–99%) | In 1 condition |
| ATP7AATPase copper transporting alpha | Very often (80–99%) | In 1 condition |
| CD28CD28 molecule | Very often (80–99%) | In 2 conditions |
| CSTBcystatin B | Very often (80–99%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Very often (80–99%) | In 2 conditions |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Very often (80–99%) | In 1 condition |
| DDB2damage specific DNA binding protein 2 | Very often (80–99%) | In 1 condition |
| EDARectodysplasin A receptor | Very often (80–99%) | In 2 conditions |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Very often (80–99%) | In 4 conditions |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Very often (80–99%) | In 3 conditions |
| ERCC5ERCC excision repair 5, endonuclease | Very often (80–99%) | In 2 conditions |
| FLGfilaggrin | Very often (80–99%) | In 2 conditions |
| GSNgelsolin | Very often (80–99%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Very often (80–99%) | In 2 conditions |
| LIPNlipase family member N | Very often (80–99%) | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Very often (80–99%) | In 3 conditions |
| MAP2K2mitogen-activated protein kinase kinase 2 | Very often (80–99%) | In 2 conditions |
| NIPAL4NIPA like domain containing 4 | Very often (80–99%) | In 2 conditions |
| PEPDpeptidase D | Very often (80–99%) | In 1 condition |
| PEX7peroxisomal biogenesis factor 7 | Very often (80–99%) | In 1 condition |
| PHYHphytanoyl-CoA 2-hydroxylase | Very often (80–99%) | In 1 condition |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Very often (80–99%) | In 1 condition |
| SMARCAD1SNF2 related chromatin remodeling ATPase with DExD box 1 | Very often (80–99%) | In 1 condition |
| STSsteroid sulfatase | Very often (80–99%) | In 1 condition |
| SULT2B1sulfotransferase family 2B member 1 | Very often (80–99%) | In 1 condition |
| TGM1transglutaminase 1 | Very often (80–99%) | In 1 condition |
| TNFRSF1BTNF receptor superfamily member 1B | Very often (80–99%) | In 2 conditions |
| XPAXPA, DNA damage recognition and repair factor | Very often (80–99%) | In 1 condition |
| XPCXPC complex subunit, DNA damage recognition and repair factor | Very often (80–99%) | In 1 condition |
| ABCA1ATP binding cassette subfamily A member 1 | Often (30–79%) | In 2 conditions |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Often (30–79%) | In 1 condition |
| ADAadenosine deaminase | Often (30–79%) | In 1 condition |
| ADARadenosine deaminase RNA specific | Often (30–79%) | In 1 condition |
| ALKALK receptor tyrosine kinase | Often (30–79%) | In 1 condition |
| BAP1BRCA1 associated deubiquitinase 1 | Often (30–79%) | In 1 condition |
| BORCS8BLOC-1 related complex subunit 8 | Often (30–79%) | In 1 condition |
| CASRcalcium sensing receptor | Often (30–79%) | In 1 condition |
| CAV1caveolin 1 | Often (30–79%) | In 1 condition |
| CDK4cyclin dependent kinase 4 | Often (30–79%) | In 1 condition |
| CDKN2Acyclin dependent kinase inhibitor 2A | Often (30–79%) | In 1 condition |
| CDKN2Bcyclin dependent kinase inhibitor 2B | Often (30–79%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Often (30–79%) | In 1 condition |
| CPLX1complexin 1 | Often (30–79%) | In 1 condition |
| CTBP1C-terminal binding protein 1 | Often (30–79%) | In 1 condition |
| DCLRE1CDNA cross-link repair 1C | Often (30–79%) | In 1 condition |
| DOLKdolichol kinase | Often (30–79%) | In 1 condition |
| DRG1developmentally regulated GTP binding protein 1 | Often (30–79%) | In 1 condition |
| EXOC2exocyst complex component 2 | Often (30–79%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Often (30–79%) | In 2 conditions |
| GJB3gap junction protein beta 3 | Often (30–79%) | In 1 condition |
| GJB4gap junction protein beta 4 | Often (30–79%) | In 1 condition |
| GNA11G protein subunit alpha 11 | Often (30–79%) | In 1 condition |
| GNB2G protein subunit beta 2 | Often (30–79%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Often (30–79%) | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Often (30–79%) | In 1 condition |
| IL7Rinterleukin 7 receptor | Often (30–79%) | In 1 condition |
| INSRinsulin receptor | Often (30–79%) | In 2 conditions |
| KDSR3-ketodihydrosphingosine reductase | Often (30–79%) | In 1 condition |
| KRT1keratin 1 | Often (30–79%) | In 1 condition |
| KRT14keratin 14 | Often (30–79%) | In 1 condition |
| KYNUkynureninase | Often (30–79%) | In 1 condition |
| LEF1lymphoid enhancer binding factor 1 | Often (30–79%) | In 1 condition |
| LETM1leucine zipper and EF-hand containing transmembrane protein 1 | Often (30–79%) | In 1 condition |
| LSM11LSM11, U7 small nuclear RNA associated | Often (30–79%) | In 1 condition |
| MC1Rmelanocortin 1 receptor | Often (30–79%) | In 1 condition |
| MGMTO-6-methylguanine-DNA methyltransferase | Often (30–79%) | In 1 condition |
| MITFmelanocyte inducing transcription factor | Often (30–79%) | In 1 condition |
| NELFAnegative elongation factor complex member A | Often (30–79%) | In 1 condition |
| NKX2-5NK2 homeobox 5 | Often (30–79%) | In 1 condition |
| NLRP1NLR family pyrin domain containing 1 | Often (30–79%) | In 1 condition |
| NOD2nucleotide binding oligomerization domain containing 2 | Often (30–79%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| NSD2nuclear receptor binding SET domain protein 2 | Often (30–79%) | In 1 condition |
| NTRK1neurotrophic receptor tyrosine kinase 1 | Often (30–79%) | In 1 condition |
| NUDCD3NudC domain containing 3 | Often (30–79%) | In 1 condition |
| PAX8paired box 8 | Often (30–79%) | In 2 conditions |
| PCNTpericentrin | Often (30–79%) | In 1 condition |
| PIGGphosphatidylinositol glycan anchor biosynthesis class G (EMM blood group) | Often (30–79%) | In 1 condition |
| PIGHphosphatidylinositol glycan anchor biosynthesis class H | Often (30–79%) | In 1 condition |
| PIGLphosphatidylinositol glycan anchor biosynthesis class L | Often (30–79%) | In 1 condition |
| POLHDNA polymerase eta | Often (30–79%) | In 1 condition |
| PORCNporcupine O-acyltransferase | Often (30–79%) | In 1 condition |
| POT1protection of telomeres 1 | Often (30–79%) | In 1 condition |
| PRKD1protein kinase D1 | Often (30–79%) | In 1 condition |
| PSMB10proteasome 20S subunit beta 10 | Often (30–79%) | In 1 condition |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Often (30–79%) | In 3 conditions |
| RAG1recombination activating 1 | Often (30–79%) | In 1 condition |
| RAG2recombination activating 2 | Often (30–79%) | In 1 condition |
| RIPK4receptor interacting serine/threonine kinase 4 | Often (30–79%) | In 2 conditions |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Often (30–79%) | In 1 condition |
| RNASEH2Aribonuclease H2 subunit A | Often (30–79%) | In 1 condition |
| RNASEH2Bribonuclease H2 subunit B | Often (30–79%) | In 1 condition |
| RNASEH2Cribonuclease H2 subunit C | Often (30–79%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Often (30–79%) | In 2 conditions |
| SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Often (30–79%) | In 2 conditions |
| SASH1SAM and SH3 domain containing 1 | Often (30–79%) | In 1 condition |
| SOX5SRY-box transcription factor 5 | Often (30–79%) | In 1 condition |
| SRD5A3steroid 5 alpha-reductase 3 | Often (30–79%) | In 1 condition |
| TERF2IPTERF2 interacting protein | Often (30–79%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Often (30–79%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Often (30–79%) | In 1 condition |
| TRHRthyrotropin releasing hormone receptor | Often (30–79%) | In 1 condition |
| TRPM1transient receptor potential cation channel subfamily M member 1 | Often (30–79%) | In 1 condition |
| TSHBthyroid stimulating hormone subunit beta | Often (30–79%) | In 2 conditions |
| TSHZ3teashirt zinc finger homeobox 3 | Often (30–79%) | In 1 condition |
| TWIST2twist family bHLH transcription factor 2 | Often (30–79%) | In 3 conditions |
| WNT10BWnt family member 10B | Often (30–79%) | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Often (30–79%) | In 1 condition |
| AARS1alanyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| ALG11ALG11 alpha-1,2-mannosyltransferase | Sometimes (5–29%) | In 1 condition |
| ARNT2aryl hydrocarbon receptor nuclear translocator 2 | Sometimes (5–29%) | In 1 condition |
| BCKDKbranched chain keto acid dehydrogenase kinase | Sometimes (5–29%) | In 1 condition |
| CAMK2Bcalcium/calmodulin dependent protein kinase II beta | Sometimes (5–29%) | In 1 condition |
| CARS1cysteinyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| CASTcalpastatin | Sometimes (5–29%) | In 1 condition |
| COG6component of oligomeric golgi complex 6 | Sometimes (5–29%) | In 1 condition |
| CTSCcathepsin C | Sometimes (5–29%) | In 1 condition |
| DDOSTdolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit | Sometimes (5–29%) | In 1 condition |
| DPP9dipeptidyl peptidase 9 | Sometimes (5–29%) | In 1 condition |
| FBXO22F-box protein 22 | Sometimes (5–29%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Sometimes (5–29%) | In 1 condition |
| FOSL2FOS like 2, AP-1 transcription factor subunit | Sometimes (5–29%) | In 1 condition |
| GABBR1gamma-aminobutyric acid type B receptor subunit 1 | Sometimes (5–29%) | In 1 condition |
| GINS1GINS complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| GTF2H5general transcription factor IIH subunit 5 | Sometimes (5–29%) | In 1 condition |
| GTF3C3general transcription factor IIIC subunit 3 | Sometimes (5–29%) | In 1 condition |
| HESX1HESX homeobox 1 | Sometimes (5–29%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Sometimes (5–29%) | In 1 condition |
| KCTD1potassium channel tetramerization domain containing 1 | Sometimes (5–29%) | In 1 condition |
| KIF11kinesin family member 11 | Sometimes (5–29%) | In 1 condition |
| KIF15kinesin family member 15 | Sometimes (5–29%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Sometimes (5–29%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Sometimes (5–29%) | In 2 conditions |
| MPLKIPM-phase specific PLK1 interacting protein | Sometimes (5–29%) | In 1 condition |
| MYSM1Myb like, SWIRM and MPN domains 1 | Sometimes (5–29%) | In 2 conditions |
| NOTCH2notch receptor 2 | Sometimes (5–29%) | In 1 condition |
| ODC1ornithine decarboxylase 1 | Sometimes (5–29%) | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Sometimes (5–29%) | In 1 condition |
| OTX2orthodenticle homeobox 2 | Sometimes (5–29%) | In 1 condition |
| PROKR2prokineticin receptor 2 | Sometimes (5–29%) | In 1 condition |
| RALGAPA1Ral GTPase activating protein catalytic subunit alpha 1 | Sometimes (5–29%) | In 1 condition |
| RNF113Aring finger protein 113A | Sometimes (5–29%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Sometimes (5–29%) | In 1 condition |
| SATB1SATB homeobox 1 | Sometimes (5–29%) | In 1 condition |
| SKIC2SKI2 subunit of superkiller complex | Sometimes (5–29%) | In 1 condition |
| SKIC3SKI3 subunit of superkiller complex | Sometimes (5–29%) | In 1 condition |
| SLF2SMC5/6 complex localization factor 2 | Sometimes (5–29%) | In 1 condition |
| SMG8SMG8 nonsense mediated mRNA decay factor | Sometimes (5–29%) | In 1 condition |
| SOX2SRY-box transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| SOX3SRY-box transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| SPENspen family transcriptional repressor | Sometimes (5–29%) | In 1 condition |
| SPRED2sprouty related EVH1 domain containing 2 | Sometimes (5–29%) | In 1 condition |
| TARS1threonyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| TTC5tetratricopeptide repeat domain 5 | Sometimes (5–29%) | In 1 condition |
| ZNF341zinc finger protein 341 | Sometimes (5–29%) | In 1 condition |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Rarely (1–4%) | In 1 condition |
| RYR1ryanodine receptor 1 | Rarely (1–4%) | In 1 condition |
| CLDN1claudin 1 | Not recorded | In 1 condition |
| CLDN10claudin 10 | Not recorded | In 1 condition |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Not recorded | In 1 condition |
| FUCA1alpha-L-fucosidase 1 | Not recorded | In 1 condition |
| IFT43intraflagellar transport 43 | Not recorded | In 1 condition |
| KANSL1KAT8 regulatory NSL complex subunit 1 | Not recorded | In 1 condition |
| MPDU1mannose-P-dolichol utilization defect 1 | Not recorded | In 1 condition |
| NAGAalpha-N-acetylgalactosaminidase | Not recorded | In 1 condition |
| OSMRoncostatin M receptor | Not recorded | In 1 condition |
| PAHphenylalanine hydroxylase | Not recorded | In 1 condition |
| PEX11Bperoxisomal biogenesis factor 11 beta | Not recorded | In 1 condition |
| RNF168ring finger protein 168 | Not recorded | In 1 condition |
| SLC5A5solute carrier family 5 member 5 | Not recorded | In 1 condition |
| THRAthyroid hormone receptor alpha | Not recorded | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Not recorded | In 1 condition |
| UVSSAUV stimulated scaffold protein A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
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