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Gene

VCP

valosin containing protein

Summary

Cytogenetic location
9p13.3
Coordinates
Chromosome 9: 35,056,064–35,072,625 (GRCh38)
Exons
17 exons across 16.6 kb
Protein
806 amino acids
Inheritance
Autosomal dominant
Also known as
IBMPFD, p97, CDC48, TERA
MANE Select transcript
ENST00000358901.11NM_007126.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Amyotrophic Lateral Sclerosis (ALS)

    • Amyotrophic Lateral Sclerosis

      A neurodegenerative disorder of upper and lower motor neurons, occurring in sporadic and familial forms.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Tofersen (Qalsody, FDA 2023) for SOD1-ALS; ASO trials for C9orf72 and FUS; riluzole; edaravone; AMX0035 (sodium phenylbutyrate-taurursodiol); multidisciplinary ALS clinic care; respiratory support; genetic counseling for family members

  • Distal Myopathies

    • VCP multisystem proteinopathy (inclusion body myopathy with Paget disease of bone and frontotemporal dementia)Autosomal dominant

      A condition caused by VCP variants that can combine adult-onset muscle weakness with Paget disease of bone and frontotemporal dementia.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong

  • Frontotemporal Dementia

    • Autosomal dominant

      Frontotemporal dementia (FTD) comprises a group of neurodegenerative disorders, characterized by progressive changes in behavior, executive dysfunction and language impairment, as a result of degeneration of the medial prefrontal and frontoinsular cortices. Four clinical subtypes have been identified: semantic dementia, progressive non-fluent aphasia, behavioral variant FTD and right temporal lobar atrophy.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong
    • Frontotemporal Dementia and/or Amyotrophic Lateral SclerosisAutosomal dominant

      Umbrella term for the genetic frontotemporal dementia and ALS spectrum, including forms caused by C9orf72, TBK1, VCP, SQSTM1 and other genes.

      • 2 GenCC submitters rate it definitive or strong

Broader groupings

  • Charcot-Marie-Tooth Disease

    • One of 62 genes linked to it

      A group of inherited peripheral neuropathies causing progressive weakness and wasting of the distal muscles and loss of sensation, mainly in the feet and hands.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Genetic counseling, subtype-specific monitoring, physical therapy, orthotics, neurotoxic drug avoidance, gene-specific clinical trials, surveillance for associated features

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How VCP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 9, with a bracket where VCP sits. VCP and 25 genes near it on chromosome 9, from 34,564,345 to 35,564,344.Chromosome 99p13.3p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.334.6 Mb34.8 Mb35 Mb35.2 Mb35.4 MbCNTFR: 34,551,423–34,593,478, reverse strandCNTFRRPP25L: 34,610,486–34,612,605, reverse strandDCTN3: 34,613,545–34,620,529, reverse strandARID3C: 34,621,049–34,630,503, reverse strandSIGMAR1: 34,631,716–34,637,844, reverse strandGALT: 34,637,367–34,651,754, forward strand: 34,646,631–34,661,886, forward strandIL11RA: 34,651,582–34,661,902, forward strandCCL27: 34,661,880–34,664,048, reverse strandCCL27: 34,664,163–34,666,122, reverse strandCCL19: 34,689,562–34,691,355, reverse strandCCL19CCL21: 34,709,005–34,710,167, reverse strandCCL21SPATA31F1: 34,719,196–34,729,538, reverse strandSPATA31F1SPATA31F3: 34,889,062–34,895,797, reverse strandSPATA31F3PHF24: 34,957,608–34,982,544, forward strandPHF24DNAJB5: 34,989,641–34,999,403, forward strandDNAJB5SPATA31G1: 35,041,095–35,045,986, forward strandSPATA31G1VCP: 35,056,064–35,072,625, reverse strandVCP: 35,065,339–35,074,175, reverse strandFANCG: 35,073,793–35,082,444, reverse strandFANCGPIGO: 35,085,492–35,096,632, reverse strandSTOML2: 35,099,469–35,103,195, reverse strandATOSB: 35,104,112–35,116,357, reverse strandATOSBUNC13B: 35,161,829–35,405,339, forward strandUNC13BRUSC2: 35,489,670–35,562,266, forward strandRUSC2CIMIP2B: 35,561,831–35,563,914, reverse strandCIMIP2BDiagram of VCP: 17 exons on the reverse strand of chromosome 9Exon 12: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 5: 11 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 3: 10 known disease-causing sitesExon 17: 35,056,064–35,057,222, 1,159 basesExon 16: 35,057,376–35,057,530, 155 basesExon 15: 35,059,064–35,059,219, 156 basesExon 14: 35,059,493–35,059,801, 309 basesExon 13: 35,060,313–35,060,525, 213 basesExon 12: 35,060,801–35,060,923, 123 basesExon 11: 35,061,015–35,061,179, 165 basesExon 10: 35,061,577–35,061,689, 113 basesExon 9: 35,062,003–35,062,138, 136 basesExon 8: 35,062,217–35,062,350, 134 basesExon 7: 35,062,978–35,063,080, 103 basesExon 6: 35,064,154–35,064,285, 132 basesExon 5: 35,065,251–35,065,381, 131 basesExon 4: 35,066,675–35,066,817, 143 basesExon 3: 35,067,891–35,068,063, 173 basesExon 2: 35,068,251–35,068,362, 112 basesExon 1: 35,072,337–35,072,625, 289 bases1716141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.7 kb of the gene's 16.6 kb; 2,421 of those bases code for the protein.

How a genome test reads VCP

30

positions in VCP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 16.6 kb of VCP, introns included, not only the 3.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). VCP gene: valosin containing protein. Retrieved 17 October 2026, from https://dantelabs.com/genes/vcp

Vancouver

Dante Labs. VCP gene: valosin containing protein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/vcp

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