Skip to content
Use your HSA or FSA funds

Gene

CCNF

cyclin F

Summary

Cytogenetic location
16p13.3
Coordinates
Chromosome 16: 2,429,447–2,458,854 (GRCh38)
Exons
17 exons across 29.4 kb
Protein
786 amino acids
Inheritance
Autosomal dominant
Also known as
FBX1, FBXO1
MANE Select transcript
ENST00000397066.9NM_001761.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Amyotrophic Lateral Sclerosis (ALS)

    • Amyotrophic Lateral Sclerosis

      A neurodegenerative disorder of upper and lower motor neurons, occurring in sporadic and familial forms.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Tofersen (Qalsody, FDA 2023) for SOD1-ALS; ASO trials for C9orf72 and FUS; riluzole; edaravone; AMX0035 (sodium phenylbutyrate-taurursodiol); multidisciplinary ALS clinic care; respiratory support; genetic counseling for family members

  • Frontotemporal Dementia

    • Frontotemporal Dementia and/or Amyotrophic Lateral SclerosisAutosomal dominant

      Umbrella term for the genetic frontotemporal dementia and ALS spectrum, including forms caused by C9orf72, TBK1, VCP, SQSTM1 and other genes.

      • 1 GenCC submitter rates it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How CCNF is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 16, with a bracket where CCNF sits. CCNF and 45 genes near it on chromosome 16, from 1,944,151 to 2,944,150.Chromosome 1616p13.3p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.32 Mb2.2 Mb2.4 Mb2.6 Mb2.8 MbRPL3L: 1,943,791–1,957,606, reverse strandNDUFB10: 1,959,500–1,962,105, forward strandRPS2: 1,961,987–1,965,510, reverse strandRNF151: 1,966,823–1,968,975, forward strandTBL3: 1,971,972–1,983,056, forward strandTBL3NOXO1: 1,978,912–1,984,636, reverse strandGFER: 1,983,699–1,987,749, forward strandSYNGR3: 1,989,637–1,994,275, forward strandZNF598: 1,997,654–2,009,821, reverse strandZNF598NPW: 2,009,926–2,020,755, forward strandNPWNHERF2: 2,025,356–2,039,026, forward strandNHERF2NTHL1: 2,039,814–2,047,866, reverse strandNTHL1TSC2: 2,047,345–2,089,491, forward strandTSC2PKD1: 2,088,708–2,135,898, reverse strandPKD1RAB26: 2,140,803–2,154,165, forward strandRAB26TRAF7: 2,155,692–2,178,129, forward strandTRAF7CASKIN1: 2,177,180–2,196,788, reverse strandMLST8: 2,204,248–2,209,453, forward strandBRICD5: 2,209,252–2,210,905, reverse strandPGP: 2,211,593–2,214,846, reverse strandPGPE4F1: 2,223,440–2,235,743, forward strandE4F1DNASE1L2: 2,235,816–2,238,711, forward strandDNASE1L2ECI1: 2,239,376–2,252,300, reverse strandECI1RNPS1: 2,253,116–2,268,413, reverse strandRNPS1ABCA3: 2,275,878–2,340,788, reverse strandABCA3CCNF: 2,429,447–2,458,854, forward strandCCNFTEDC2: 2,460,085–2,464,963, forward strandTEDC2NTN3: 2,471,286–2,474,145, forward strandNTN3TBC1D24: 2,475,051–2,509,671, forward strandTBC1D24: 2,496,032–2,520,218, forward strandATP6V0C: 2,513,713–2,520,218, forward strand: 2,513,965–2,527,955, forward strandAMDHD2: 2,520,340–2,531,422, forward strandCEMP1: 2,530,035–2,531,417, reverse strandPDPK1: 2,537,969–2,603,190, forward strandPDPK1KCTD5: 2,682,516–2,709,030, forward strandKCTD5PRSS27: 2,712,419–2,721,270, reverse strandPRSS27SRRM2: 2,752,008–2,772,538, forward strandSRRM2ELOB: 2,771,413–2,777,320, reverse strandELOBPRSS33: 2,783,926–2,787,948, reverse strandPRSS33PRSS41: 2,798,470–2,805,304, forward strandPRSS41PRSS21: 2,817,130–2,826,304, forward strandPRSS21ZG16B: 2,830,162–2,839,585, forward strandZG16BPRSS22: 2,852,728–2,858,677, reverse strandPRSS22FLYWCH2: 2,882,868–2,903,099, forward strandFLYWCH2FLYWCH1: 2,911,599–2,951,208, forward strandFLYWCH1Diagram of CCNF: 17 exons on the forward strand of chromosome 16Exon 16: 1 known disease-causing siteExon 1: 2,429,447–2,429,497, 51 basesExon 2: 2,431,130–2,431,284, 155 basesExon 3: 2,432,961–2,433,067, 107 basesExon 4: 2,435,806–2,435,873, 68 basesExon 5: 2,437,129–2,437,322, 194 basesExon 6: 2,438,070–2,438,123, 54 basesExon 7: 2,439,353–2,439,457, 105 basesExon 8: 2,439,749–2,439,826, 78 basesExon 9: 2,443,649–2,443,800, 152 basesExon 10: 2,445,458–2,445,622, 165 basesExon 11: 2,448,855–2,448,978, 124 basesExon 12: 2,449,282–2,449,462, 181 basesExon 13: 2,449,828–2,449,915, 88 basesExon 14: 2,453,210–2,453,309, 100 basesExon 15: 2,453,410–2,453,537, 128 basesExon 16: 2,455,395–2,455,564, 170 basesExon 17: 2,456,545–2,458,854, 2,310 bases1246810121416175′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.2 kb of the gene's 29.4 kb; 2,361 of those bases code for the protein.

How a genome test reads CCNF

1

position in CCNF where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 29.4 kb of CCNF, introns included, not only the 4.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CCNF gene: cyclin F. Retrieved 16 October 2026, from https://dantelabs.com/genes/ccnf

Vancouver

Dante Labs. CCNF gene: cyclin F [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ccnf

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test