Trait
Joint pain
Clinical name: Arthralgia
Joint pain.
Summary
- Also called
- Joint pains, Arthralgias
- Body system
- Constitutional symptom
Reference genomeGRCh38hg38
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Read the genes linked to Joint pain, and the rest of your genome, with one test.
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Get my Genome Test202 genes linked to Joint pain
Changes in these genes cause rare conditions in which Joint pain is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AP1S3adaptor related protein complex 1 subunit sigma 3 | Always | In 1 condition |
| ASAH1N-acylsphingosine amidohydrolase 1 | Always | In 2 conditions |
| C1QBcomplement C1q B chain | Always | In 1 condition |
| CD81CD81 molecule | Always | In 1 condition |
| COL11A2collagen type XI alpha 2 chain | Always | In 3 conditions |
| COL2A1collagen type II alpha 1 chain | Always | In 8 conditions |
| FLNAfilamin A | Always | In 1 condition |
| GNB2G protein subunit beta 2 | Always | In 1 condition |
| GNPTGN-acetylglucosamine-1-phosphate transferase subunit gamma | Always | In 1 condition |
| IKZF2IKAROS family zinc finger 2 | Always | In 1 condition |
| IL36RNinterleukin 36 receptor antagonist | Always | In 1 condition |
| IRF4interferon regulatory factor 4 | Always | In 2 conditions |
| LBRlamin B receptor | Always | In 1 condition |
| LPIN2lipin 2 | Always | In 2 conditions |
| LYNLYN proto-oncogene, Src family tyrosine kinase | Always | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Always | In 7 conditions |
| MMP2matrix metallopeptidase 2 | Always | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Always | In 6 conditions |
| OTULINOTU deubiquitinase with linear linkage specificity | Always | In 1 condition |
| PIGTphosphatidylinositol glycan anchor biosynthesis class T | Always | In 1 condition |
| PLCG2phospholipase C gamma 2 | Always | In 1 condition |
| POMPproteasome maturation protein | Always | In 1 condition |
| PSMB8proteasome 20S subunit beta 8 | Always | In 1 condition |
| SOSTsclerostin | Always | In 1 condition |
| TREX1three prime repair exonuclease 1 | Always | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Very often (80–99%) | In 1 condition |
| ANKHANKH inorganic pyrophosphate transport regulator | Very often (80–99%) | In 1 condition |
| ANTXR2ANTXR cell adhesion molecule 2 | Very often (80–99%) | In 1 condition |
| ATP7BATPase copper transporting beta | Very often (80–99%) | In 1 condition |
| CCN2cellular communication network factor 2 | Very often (80–99%) | In 2 conditions |
| CD4CD4 molecule | Very often (80–99%) | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Very often (80–99%) | In 2 conditions |
| COL11A1collagen type XI alpha 1 chain | Very often (80–99%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Very often (80–99%) | In 1 condition |
| DDB2damage specific DNA binding protein 2 | Very often (80–99%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Very often (80–99%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Very often (80–99%) | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Very often (80–99%) | In 1 condition |
| ERCC5ERCC excision repair 5, endonuclease | Very often (80–99%) | In 1 condition |
| GLAgalactosidase alpha | Very often (80–99%) | In 1 condition |
Show 162 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| GPR101G protein-coupled receptor 101 | Very often (80–99%) | In 2 conditions |
| HGDhomogentisate 1,2-dioxygenase | Very often (80–99%) | In 2 conditions |
| HLA-Bmajor histocompatibility complex, class I, B | Very often (80–99%) | In 4 conditions |
| HLA-DPA1major histocompatibility complex, class II, DP alpha 1 | Very often (80–99%) | In 1 condition |
| HLA-DPB1major histocompatibility complex, class II, DP beta 1 | Very often (80–99%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Very often (80–99%) | In 3 conditions |
| IL6interleukin 6 | Very often (80–99%) | In 1 condition |
| LACC1laccase domain multifunctional purine nucleosidase 1 | Very often (80–99%) | In 1 condition |
| MFN2mitofusin 2 | Very often (80–99%) | In 1 condition |
| MIFmacrophage migration inhibitory factor | Very often (80–99%) | In 1 condition |
| MVKmevalonate kinase | Very often (80–99%) | In 3 conditions |
| NLRP12NLR family pyrin domain containing 12 | Very often (80–99%) | In 1 condition |
| NOD2nucleotide binding oligomerization domain containing 2 | Very often (80–99%) | In 2 conditions |
| PLAAT3phospholipase A and acyltransferase 3 | Very often (80–99%) | In 1 condition |
| PRTN3proteinase 3 | Very often (80–99%) | In 1 condition |
| PTH1Rparathyroid hormone 1 receptor | Very often (80–99%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Very often (80–99%) | In 3 conditions |
| SEPTIN9septin 9 | Very often (80–99%) | In 1 condition |
| SLC26A2solute carrier family 26 member 2 | Very often (80–99%) | In 2 conditions |
| TNFRSF11BTNF receptor superfamily member 11b | Very often (80–99%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Very often (80–99%) | In 2 conditions |
| TYROBPtransmembrane immune signaling adaptor TYROBP | Very often (80–99%) | In 1 condition |
| VCPvalosin containing protein | Very often (80–99%) | In 1 condition |
| XPAXPA, DNA damage recognition and repair factor | Very often (80–99%) | In 1 condition |
| XPCXPC complex subunit, DNA damage recognition and repair factor | Very often (80–99%) | In 1 condition |
| ABCG5ATP binding cassette subfamily G member 5 | Often (30–79%) | In 2 conditions |
| ABCG8ATP binding cassette subfamily G member 8 | Often (30–79%) | In 3 conditions |
| ADA2adenosine deaminase 2 | Often (30–79%) | In 1 condition |
| ANKRD55ankyrin repeat domain 55 | Often (30–79%) | In 1 condition |
| ARSBarylsulfatase B | Often (30–79%) | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Often (30–79%) | In 2 conditions |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Often (30–79%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Often (30–79%) | In 1 condition |
| C1Rcomplement C1r | Often (30–79%) | In 1 condition |
| C1Scomplement C1s | Often (30–79%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Often (30–79%) | In 1 condition |
| CAV1caveolin 1 | Often (30–79%) | In 1 condition |
| CBLCbl proto-oncogene | Often (30–79%) | In 1 condition |
| CCN6cellular communication network factor 6 | Often (30–79%) | In 1 condition |
| CCR1C-C motif chemokine receptor 1 | Often (30–79%) | In 1 condition |
| CCR6C-C motif chemokine receptor 6 | Often (30–79%) | In 1 condition |
| CD247CD247 molecule | Often (30–79%) | In 1 condition |
| CHST11carbohydrate sulfotransferase 11 | Often (30–79%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Often (30–79%) | In 1 condition |
| COL1A1collagen type I alpha 1 chain | Often (30–79%) | In 2 conditions |
| COL1A2collagen type I alpha 2 chain | Often (30–79%) | In 1 condition |
| COL9A1collagen type IX alpha 1 chain | Often (30–79%) | In 2 conditions |
| COL9A2collagen type IX alpha 2 chain | Often (30–79%) | In 1 condition |
| COL9A3collagen type IX alpha 3 chain | Often (30–79%) | In 1 condition |
| COMPcartilage oligomeric matrix protein | Often (30–79%) | In 2 conditions |
| DDRGK1DDRGK domain containing 1 | Often (30–79%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Often (30–79%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Often (30–79%) | In 1 condition |
| ELNelastin | Often (30–79%) | In 1 condition |
| EMILIN1elastin microfibril interfacer 1 | Often (30–79%) | In 1 condition |
| EPORerythropoietin receptor | Often (30–79%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Often (30–79%) | In 1 condition |
| F8coagulation factor VIII | Often (30–79%) | In 2 conditions |
| FASFas cell surface death receptor | Often (30–79%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Often (30–79%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Often (30–79%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Often (30–79%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Often (30–79%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Often (30–79%) | In 4 conditions |
| IFNGR1interferon gamma receptor 1 | Often (30–79%) | In 1 condition |
| IL10interleukin 10 | Often (30–79%) | In 2 conditions |
| IL12Ainterleukin 12A | Often (30–79%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Often (30–79%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Often (30–79%) | In 1 condition |
| IL2RAinterleukin 2 receptor subunit alpha | Often (30–79%) | In 1 condition |
| IL2RBinterleukin 2 receptor subunit beta | Often (30–79%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Often (30–79%) | In 1 condition |
| JAK2Janus kinase 2 | Often (30–79%) | In 1 condition |
| KIF7kinesin family member 7 | Often (30–79%) | In 1 condition |
| KLRC4killer cell lectin like receptor C4 | Often (30–79%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Often (30–79%) | In 1 condition |
| LOXL3lysyl oxidase like 3 | Often (30–79%) | In 1 condition |
| METTL27methyltransferase like 27 | Often (30–79%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Often (30–79%) | In 1 condition |
| NLRC4NLR family CARD domain containing 4 | Often (30–79%) | In 2 conditions |
| NOTCH2notch receptor 2 | Often (30–79%) | In 1 condition |
| PHEXphosphate regulating endopeptidase X-linked | Often (30–79%) | In 2 conditions |
| PKDCCprotein kinase domain containing, cytoplasmic | Often (30–79%) | In 1 condition |
| PLD4phospholipase D family member 4 | Often (30–79%) | In 1 condition |
| PSTPIP1proline-serine-threonine phosphatase interacting protein 1 | Often (30–79%) | In 1 condition |
| PTPN2protein tyrosine phosphatase non-receptor type 2 | Often (30–79%) | In 1 condition |
| PTPN6protein tyrosine phosphatase non-receptor type 6 | Often (30–79%) | In 1 condition |
| RFC2replication factor C subunit 2 | Often (30–79%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Often (30–79%) | In 1 condition |
| RRAGDRas related GTP binding D | Often (30–79%) | In 1 condition |
| RUNX1RUNX family transcription factor 1 | Often (30–79%) | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Often (30–79%) | In 1 condition |
| SMAD2SMAD family member 2 | Often (30–79%) | In 1 condition |
| SRSF2serine and arginine rich splicing factor 2 | Often (30–79%) | In 2 conditions |
| STAT4signal transducer and activator of transcription 4 | Often (30–79%) | In 3 conditions |
| STING1stimulator of interferon response cGAMP interactor 1 | Often (30–79%) | In 1 condition |
| STX1Asyntaxin 1A | Often (30–79%) | In 1 condition |
| TBL2transducin beta like 2 | Often (30–79%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Often (30–79%) | In 2 conditions |
| TLR4toll like receptor 4 | Often (30–79%) | In 1 condition |
| TLR7toll like receptor 7 | Often (30–79%) | In 1 condition |
| TMEM270transmembrane protein 270 | Often (30–79%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Often (30–79%) | In 3 conditions |
| TNXBtenascin XB | Often (30–79%) | In 2 conditions |
| TRAPPC2trafficking protein particle complex subunit 2 | Often (30–79%) | In 2 conditions |
| UBAC2UBA domain containing 2 | Often (30–79%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Often (30–79%) | In 1 condition |
| ABCC6ATP binding cassette subfamily C member 6 | Sometimes (5–29%) | In 1 condition |
| APCAPC regulator of Wnt signaling pathway | Sometimes (5–29%) | In 1 condition |
| APOBapolipoprotein B | Sometimes (5–29%) | In 1 condition |
| BCL11ABCL11 transcription factor A | Sometimes (5–29%) | In 1 condition |
| BMP6bone morphogenetic protein 6 | Sometimes (5–29%) | In 2 conditions |
| CD55CD55 molecule (Cromer blood group) | Sometimes (5–29%) | In 1 condition |
| COL10A1collagen type X alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL5A1collagen type V alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL5A2collagen type V alpha 2 chain | Sometimes (5–29%) | In 1 condition |
| COPAcoat protein complex I subunit alpha | Sometimes (5–29%) | In 1 condition |
| CTNNB1catenin beta 1 | Sometimes (5–29%) | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Sometimes (5–29%) | In 1 condition |
| FTLferritin light chain | Sometimes (5–29%) | In 1 condition |
| HBBhemoglobin subunit beta | Sometimes (5–29%) | In 3 conditions |
| HBG1hemoglobin subunit gamma 1 | Sometimes (5–29%) | In 1 condition |
| HBG2hemoglobin subunit gamma 2 | Sometimes (5–29%) | In 1 condition |
| HFEhomeostatic iron regulator | Sometimes (5–29%) | In 1 condition |
| IGHG2immunoglobulin heavy constant gamma 2 (G2m marker) | Sometimes (5–29%) | In 1 condition |
| IGKCimmunoglobulin kappa constant | Sometimes (5–29%) | In 1 condition |
| IL12Binterleukin 12B | Sometimes (5–29%) | In 1 condition |
| IRAK1interleukin 1 receptor associated kinase 1 | Sometimes (5–29%) | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| KLF1KLF transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| LDLRlow density lipoprotein receptor | Sometimes (5–29%) | In 1 condition |
| LDLRAP1low density lipoprotein receptor adaptor protein 1 | Sometimes (5–29%) | In 1 condition |
| LEMD3LEM domain containing 3 | Sometimes (5–29%) | In 1 condition |
| LMNAlamin A/C | Sometimes (5–29%) | In 1 condition |
| LMNB2lamin B2 | Sometimes (5–29%) | In 1 condition |
| MLXMAX dimerization protein MLX | Sometimes (5–29%) | In 1 condition |
| MYH3myosin heavy chain 3 | Sometimes (5–29%) | In 1 condition |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| PCSK9proprotein convertase subtilisin/kexin type 9 | Sometimes (5–29%) | In 1 condition |
| SAT1spermidine/spermine N1-acetyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| SFRP4secreted frizzled related protein 4 | Sometimes (5–29%) | In 2 conditions |
| SMPD1sphingomyelin phosphodiesterase 1 | Sometimes (5–29%) | In 1 condition |
| SPP1secreted phosphoprotein 1 | Sometimes (5–29%) | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Rarely (1–4%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Rarely (1–4%) | In 2 conditions |
| ASPNasporin | Not recorded | In 1 condition |
| CD244CD244 molecule | Not recorded | In 1 condition |
| CIITAclass II major histocompatibility complex transactivator | Not recorded | In 1 condition |
| DSEdermatan sulfate epimerase | Not recorded | In 1 condition |
| HLA-DQA1major histocompatibility complex, class II, DQ alpha 1 | Not recorded | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Not recorded | In 1 condition |
| IL1RNinterleukin 1 receptor antagonist | Not recorded | In 1 condition |
| MAFBMAF bZIP transcription factor B | Not recorded | In 1 condition |
| MATN3matrilin 3 | Not recorded | In 1 condition |
| MSMO1methylsterol monooxygenase 1 | Not recorded | In 1 condition |
| NFKBIL1NFKB inhibitor like 1 | Not recorded | In 1 condition |
| PSMB4proteasome 20S subunit beta 4 | Not recorded | In 1 condition |
| SLC22A4solute carrier family 22 member 4 | Not recorded | In 1 condition |
| SLC40A1solute carrier family 40 member 1 | Not recorded | In 1 condition |
| TRPS1transcriptional repressor GATA binding 1 | Not recorded | In 1 condition |
| UBA1ubiquitin like modifier activating enzyme 1 | Not recorded | In 1 condition |
| UFSP2UFM1 specific peptidase 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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