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Gene

HNRNPA2B1

heterogeneous nuclear ribonucleoprotein A2/B1

Summary

Cytogenetic location
7p15.2
Coordinates
Chromosome 7: 26,189,927–26,200,746 (GRCh38)
Exons
11 exons across 10.8 kb
Protein
341 amino acids
Inheritance
Autosomal dominant
Also known as
HNRNPA2, HNRNPB1
Previous symbols
HNRPA2B1
MANE Select transcript
ENST00000618183.5NM_002137.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Distal Myopathies

    • VCP multisystem proteinopathy (inclusion body myopathy with Paget disease of bone and frontotemporal dementia)Autosomal dominant

      A condition caused by VCP variants that can combine adult-onset muscle weakness with Paget disease of bone and frontotemporal dementia.

      • ClinGen rates the link moderate
      • 1 GenCC submitter rates it definitive or strong

  • Frontotemporal Dementia

    • Autosomal dominant

      Frontotemporal dementia (FTD) comprises a group of neurodegenerative disorders, characterized by progressive changes in behavior, executive dysfunction and language impairment, as a result of degeneration of the medial prefrontal and frontoinsular cortices. Four clinical subtypes have been identified: semantic dementia, progressive non-fluent aphasia, behavioral variant FTD and right temporal lobar atrophy.

      • ClinGen rates the link moderate
      • 1 GenCC submitter rates it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How HNRNPA2B1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 7, with a bracket where HNRNPA2B1 sits. HNRNPA2B1 and 4 genes near it on chromosome 7, from 25,695,337 to 26,695,336.Chromosome 77p15.2p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.325.8 Mb26 Mb26.2 Mb26.4 Mb26.6 MbNFE2L3: 26,152,190–26,190,901, forward strandNFE2L3HNRNPA2B1: 26,189,927–26,200,746, reverse strandHNRNPA2B1CBX3: 26,200,568–26,213,607, forward strandCBX3SNX10: 26,291,851–26,374,383, forward strandSNX10SKAP2: 26,667,003–26,995,239, reverse strandSKAP2Diagram of HNRNPA2B1: 11 exons on the reverse strand of chromosome 7Exon 10: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 11: 26,189,927–26,192,338, 2,412 basesExon 10: 26,192,495–26,192,577, 83 basesExon 9: 26,193,251–26,193,373, 123 basesExon 8: 26,193,575–26,193,694, 120 basesExon 7: 26,195,847–26,195,909, 63 basesExon 6: 26,196,401–26,196,481, 81 basesExon 5: 26,196,557–26,196,658, 102 basesExon 4: 26,196,807–26,197,017, 211 basesExon 3: 26,197,315–26,197,461, 147 basesExon 2: 26,197,622–26,197,732, 111 basesExon 1: 26,200,572–26,200,746, 175 bases11109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.6 kb of the gene's 10.8 kb; 1,026 of those bases code for the protein.

How a genome test reads HNRNPA2B1

2

positions in HNRNPA2B1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 10.8 kb of HNRNPA2B1, introns included, not only the 3.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HNRNPA2B1 gene: heterogeneous nuclear ribonucleoprotein A2/B1. Retrieved 16 October 2026, from https://dantelabs.com/genes/hnrnpa2b1

Vancouver

Dante Labs. HNRNPA2B1 gene: heterogeneous nuclear ribonucleoprotein A2/B1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/hnrnpa2b1

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