Trait
Difficulty running
Reduced ability to run.
Summary
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test58 genes linked to Difficulty running
Changes in these genes cause rare conditions in which Difficulty running is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AGRNagrin | Always | In 1 condition |
| DARS2aspartyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| FHL1four and a half LIM domains 1 | Always | In 1 condition |
| KIF1Akinesin family member 1A | Always | In 1 condition |
| LAMA2laminin subunit alpha 2 | Always | In 1 condition |
| LMNAlamin A/C | Always | In 1 condition |
| REEP2receptor accessory protein 2 | Always | In 1 condition |
| RYR3ryanodine receptor 3 | Always | In 1 condition |
| SNUPNsnurportin 1 | Always | In 1 condition |
| TTNtitin | Always | In 2 conditions |
| YARS1tyrosyl-tRNA synthetase 1 | Always | In 1 condition |
| ADSS1adenylosuccinate synthase 1 | Often (30–79%) | In 1 condition |
| ANO5anoctamin 5 | Often (30–79%) | In 2 conditions |
| BIN1bridging integrator 1 | Often (30–79%) | In 1 condition |
| COL6A1collagen type VI alpha 1 chain | Often (30–79%) | In 1 condition |
| FLNCfilamin C | Often (30–79%) | In 1 condition |
| KCNC3potassium voltage-gated channel subfamily C member 3 | Often (30–79%) | In 1 condition |
| KYkyphoscoliosis peptidase | Often (30–79%) | In 1 condition |
| MFN2mitofusin 2 | Often (30–79%) | In 1 condition |
| MICU1mitochondrial calcium uptake 1 | Often (30–79%) | In 2 conditions |
| MORC2MORC family CW-type zinc finger 2 | Often (30–79%) | In 1 condition |
| MT-TEmitochondrially encoded tRNA-Glu (GAA/G) | Often (30–79%) | In 1 condition |
| NEFLneurofilament light chain | Often (30–79%) | In 1 condition |
| PNPLA2patatin like domain 2, triacylglycerol lipase | Often (30–79%) | In 2 conditions |
| REEP1receptor accessory protein 1 | Often (30–79%) | In 1 condition |
| RYR1ryanodine receptor 1 | Often (30–79%) | In 4 conditions |
| SFXN4sideroflexin 4 | Often (30–79%) | In 1 condition |
| SGCGsarcoglycan gamma | Often (30–79%) | In 1 condition |
| SPEGstriated muscle enriched protein kinase | Often (30–79%) | In 1 condition |
| VCPvalosin containing protein | Often (30–79%) | In 1 condition |
| ALG14ALG14 UDP-N-acetylglucosaminyltransferase subunit | Sometimes (5–29%) | In 1 condition |
| ALG2ALG2 alpha-1,3/1,6-mannosyltransferase | Sometimes (5–29%) | In 1 condition |
| ATP2A1ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 | Sometimes (5–29%) | In 1 condition |
| DNAJB6DnaJ heat shock protein family (Hsp40) member B6 | Sometimes (5–29%) | In 1 condition |
| DPAGT1dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 | Sometimes (5–29%) | In 1 condition |
| DYSFdysferlin | Sometimes (5–29%) | In 2 conditions |
| FKRPfukutin related protein | Sometimes (5–29%) | In 1 condition |
| GFPT1glutamine--fructose-6-phosphate transaminase 1 | Sometimes (5–29%) | In 1 condition |
| GMPPBGDP-mannose pyrophosphorylase B | Sometimes (5–29%) | In 1 condition |
| MYH7myosin heavy chain 7 | Sometimes (5–29%) | In 1 condition |
Show 18 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MYPNmyopalladin | Sometimes (5–29%) | In 1 condition |
| RAPSNreceptor associated protein of the synapse | Sometimes (5–29%) | In 1 condition |
| TNNT1troponin T1, slow skeletal type | Sometimes (5–29%) | In 1 condition |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 1 condition |
| TPM3tropomyosin 3 | Sometimes (5–29%) | In 1 condition |
| BICD2BICD cargo adaptor 2 | Not recorded | In 1 condition |
| COL12A1collagen type XII alpha 1 chain | Not recorded | In 1 condition |
| DYNC1H1dynein cytoplasmic 1 heavy chain 1 | Not recorded | In 2 conditions |
| FBXO38F-box protein 38 | Not recorded | In 1 condition |
| KBTBD13kelch repeat and BTB domain containing 13 | Not recorded | In 1 condition |
| MEGF10multiple EGF like domains 10 | Not recorded | In 1 condition |
| PEX2peroxisomal biogenesis factor 2 | Not recorded | In 1 condition |
| POPDC3popeye domain cAMP effector 3 | Not recorded | In 1 condition |
| PYROXD1pyridine nucleotide-disulphide oxidoreductase domain 1 | Not recorded | In 1 condition |
| STIM1stromal interaction molecule 1 | Not recorded | In 1 condition |
| TCAPtitin-cap | Not recorded | In 1 condition |
| TNPO3transportin 3 | Not recorded | In 1 condition |
| VMA21vacuolar ATPase assembly factor VMA21 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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