Trait
Generalized muscle weakness
Generalized weakness or decreased strength of the muscles, affecting both distal and proximal musculature.
Summary
- Also called
- Generalised muscle weakness, Generalised weakness, Generalized weakness, Muscle weakness, diffuse, Muscle weakness, generalised, Muscle weakness, generalized
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Generalized muscle weakness, and the rest of your genome, with one test.
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Get my Genome Test122 genes linked to Generalized muscle weakness
Changes in these genes cause rare conditions in which Generalized muscle weakness is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACTA1actin alpha 1, skeletal muscle | Always | In 5 conditions |
| CHRNDcholinergic receptor nicotinic delta subunit | Always | In 1 condition |
| DSEdermatan sulfate epimerase | Always | In 1 condition |
| FKRPfukutin related protein | Always | In 2 conditions |
| FKTNfukutin | Always | In 2 conditions |
| GAAalpha glucosidase | Always | In 2 conditions |
| LMOD3leiomodin 3 | Always | In 1 condition |
| MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2 | Always | In 1 condition |
| MEGF10multiple EGF like domains 10 | Always | In 1 condition |
| MUSKmuscle associated receptor tyrosine kinase | Always | In 1 condition |
| MYL2myosin light chain 2 | Always | In 2 conditions |
| POMT2protein O-mannosyltransferase 2 | Always | In 1 condition |
| RNU12RNA, U12 small nuclear | Always | In 1 condition |
| RYR1ryanodine receptor 1 | Always | In 3 conditions |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Always | In 1 condition |
| SPTLC1serine palmitoyltransferase long chain base subunit 1 | Always | In 1 condition |
| TTNtitin | Always | In 1 condition |
| UNC13Aunc-13 homolog A | Always | In 2 conditions |
| VCPvalosin containing protein | Always | In 2 conditions |
| AIFM1apoptosis inducing factor mitochondria associated 1 | Very often (80–99%) | In 1 condition |
| ANGangiogenin | Very often (80–99%) | In 1 condition |
| ANXA11annexin A11 | Very often (80–99%) | In 1 condition |
| ATXN2ataxin 2 | Very often (80–99%) | In 1 condition |
| CAPN3calpain 3 | Very often (80–99%) | In 1 condition |
| CCNFcyclin F | Very often (80–99%) | In 1 condition |
| CFAP410cilia and flagella associated protein 410 | Very often (80–99%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Very often (80–99%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Very often (80–99%) | In 1 condition |
| COL12A1collagen type XII alpha 1 chain | Very often (80–99%) | In 2 conditions |
| COL13A1collagen type XIII alpha 1 chain | Very often (80–99%) | In 1 condition |
| COL6A1collagen type VI alpha 1 chain | Very often (80–99%) | In 1 condition |
| COL6A2collagen type VI alpha 2 chain | Very often (80–99%) | In 2 conditions |
| COL6A3collagen type VI alpha 3 chain | Very often (80–99%) | In 1 condition |
| COLQcollagen like tail subunit of asymmetric acetylcholinesterase | Very often (80–99%) | In 2 conditions |
| DAOD-amino acid oxidase | Very often (80–99%) | In 1 condition |
| DCTN1dynactin subunit 1 | Very often (80–99%) | In 1 condition |
| DNAJB6DnaJ heat shock protein family (Hsp40) member B6 | Very often (80–99%) | In 1 condition |
| ERBB4erb-b2 receptor tyrosine kinase 4 | Very often (80–99%) | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Very often (80–99%) | In 1 condition |
| FUSFUS RNA binding protein | Very often (80–99%) | In 1 condition |
Show 82 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| GLE1GLE1 RNA export mediator | Very often (80–99%) | In 1 condition |
| GLT8D1glycosyltransferase 8 domain containing 1 | Very often (80–99%) | In 1 condition |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Very often (80–99%) | In 1 condition |
| KLHL41kelch like family member 41 | Very often (80–99%) | In 1 condition |
| LAMB2laminin subunit beta 2 | Very often (80–99%) | In 1 condition |
| LRP12LDL receptor related protein 12 | Very often (80–99%) | In 1 condition |
| MATR3matrin 3 | Very often (80–99%) | In 1 condition |
| NEBnebulin | Very often (80–99%) | In 2 conditions |
| NEFHneurofilament heavy chain | Very often (80–99%) | In 1 condition |
| NEK1NIMA related kinase 1 | Very often (80–99%) | In 1 condition |
| OPTNoptineurin | Very often (80–99%) | In 1 condition |
| ORAI1ORAI calcium release-activated calcium modulator 1 | Very often (80–99%) | In 1 condition |
| PFN1profilin 1 | Very often (80–99%) | In 1 condition |
| PRPHperipherin | Very often (80–99%) | In 1 condition |
| SOD1superoxide dismutase 1 | Very often (80–99%) | In 1 condition |
| SQSTM1sequestosome 1 | Very often (80–99%) | In 1 condition |
| TAF15TATA-box binding protein associated factor 15 | Very often (80–99%) | In 1 condition |
| TARDBPTAR DNA binding protein | Very often (80–99%) | In 1 condition |
| TBK1TANK binding kinase 1 | Very often (80–99%) | In 1 condition |
| TPM3tropomyosin 3 | Very often (80–99%) | In 4 conditions |
| TREM2triggering receptor expressed on myeloid cells 2 | Very often (80–99%) | In 1 condition |
| UBQLN2ubiquilin 2 | Very often (80–99%) | In 1 condition |
| VAPBVAMP associated protein B and C | Very often (80–99%) | In 1 condition |
| AARS2alanyl-tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| ACAD9acyl-CoA dehydrogenase family member 9 | Often (30–79%) | In 1 condition |
| ACY1aminoacylase 1 | Often (30–79%) | In 1 condition |
| ADCY5adenylate cyclase 5 | Often (30–79%) | In 1 condition |
| AGKacylglycerol kinase | Often (30–79%) | In 1 condition |
| BAG3BAG cochaperone 3 | Often (30–79%) | In 1 condition |
| CCND1cyclin D1 | Often (30–79%) | In 1 condition |
| CHRNA1cholinergic receptor nicotinic alpha 1 subunit | Often (30–79%) | In 2 conditions |
| COA8cytochrome c oxidase assembly factor 8 | Often (30–79%) | In 1 condition |
| CRPPACDP-L-ribitol pyrophosphorylase A | Often (30–79%) | In 1 condition |
| EXOSC9exosome component 9 | Often (30–79%) | In 1 condition |
| HTThuntingtin | Often (30–79%) | In 1 condition |
| IBA57iron-sulfur cluster assembly factor IBA57 | Often (30–79%) | In 1 condition |
| MEN1menin 1 | Often (30–79%) | In 1 condition |
| MYL1myosin light chain 1 | Often (30–79%) | In 1 condition |
| POMT1protein O-mannosyltransferase 1 | Often (30–79%) | In 1 condition |
| RANBP2RAN binding protein 2 | Often (30–79%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Often (30–79%) | In 1 condition |
| SDHAF1succinate dehydrogenase complex assembly factor 1 | Often (30–79%) | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Often (30–79%) | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Often (30–79%) | In 1 condition |
| SLC2A3solute carrier family 2 member 3 | Often (30–79%) | In 1 condition |
| YY1YY1 transcription factor | Often (30–79%) | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Sometimes (5–29%) | In 1 condition |
| DMDdystrophin | Sometimes (5–29%) | In 1 condition |
| HACD13-hydroxyacyl-CoA dehydratase 1 | Sometimes (5–29%) | In 1 condition |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Sometimes (5–29%) | In 2 conditions |
| HADHBhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | Sometimes (5–29%) | In 1 condition |
| ITGA7integrin subunit alpha 7 | Sometimes (5–29%) | In 1 condition |
| MAP3K20mitogen-activated protein kinase kinase kinase 20 | Sometimes (5–29%) | In 1 condition |
| MORC2MORC family CW-type zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| PIGNphosphatidylinositol glycan anchor biosynthesis class N | Sometimes (5–29%) | In 1 condition |
| PLECplectin | Sometimes (5–29%) | In 2 conditions |
| PLOD1procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Sometimes (5–29%) | In 1 condition |
| PNKDPNKD metallo-beta-lactamase domain containing | Sometimes (5–29%) | In 1 condition |
| PRRT2proline rich transmembrane protein 2 | Sometimes (5–29%) | In 1 condition |
| RAPSNreceptor associated protein of the synapse | Sometimes (5–29%) | In 1 condition |
| SELENONselenoprotein N | Sometimes (5–29%) | In 2 conditions |
| SLC16A2solute carrier family 16 member 2 | Sometimes (5–29%) | In 1 condition |
| SLC52A3solute carrier family 52 member 3 | Sometimes (5–29%) | In 1 condition |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 1 condition |
| UBA1ubiquitin like modifier activating enzyme 1 | Sometimes (5–29%) | In 1 condition |
| LDB3LIM domain binding 3 | Rarely (1–4%) | In 1 condition |
| ABCB6ATP binding cassette subfamily B member 6 (LAN blood group) | Not recorded | In 1 condition |
| CAVIN1caveolae associated protein 1 | Not recorded | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Not recorded | In 1 condition |
| FGF23fibroblast growth factor 23 | Not recorded | In 1 condition |
| FXYD2FXYD domain containing ion transport regulator 2 | Not recorded | In 1 condition |
| KCNJ1potassium inwardly rectifying channel subfamily J member 1 | Not recorded | In 1 condition |
| MTM1myotubularin 1 | Not recorded | In 1 condition |
| MYH2myosin heavy chain 2 | Not recorded | In 1 condition |
| MYH7myosin heavy chain 7 | Not recorded | In 1 condition |
| PLA2G6phospholipase A2 group VI | Not recorded | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Not recorded | In 2 conditions |
| POMGNT1protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | Not recorded | In 1 condition |
| SLC12A1solute carrier family 12 member 1 | Not recorded | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Not recorded | In 1 condition |
| SLC25A4solute carrier family 25 member 4 | Not recorded | In 1 condition |
| TWNKtwinkle mtDNA helicase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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