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Trait

Temporal cortical atrophy

Atrophy of the temporal cortex.

HPO HP:0007112

Summary

Body system
Abnormality of the nervous system

17 genes linked to Temporal cortical atrophy

Changes in these genes cause rare conditions in which Temporal cortical atrophy is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
AHDC1AT-hook DNA binding motif containing 1AlwaysIn 1 condition
APOEapolipoprotein EAlwaysIn 1 condition
PDE6Dphosphodiesterase 6DAlwaysIn 1 condition
PSEN2presenilin 2AlwaysIn 1 condition
RAB3ARAB3A, member RAS oncogene familyAlwaysIn 1 condition
CHMP2Bcharged multivesicular body protein 2BVery often (80–99%)In 1 condition
GRNgranulin precursorVery often (80–99%)In 1 condition
MAPTmicrotubule associated protein tauVery often (80–99%)In 1 condition
PSEN1presenilin 1Very often (80–99%)In 1 condition
TMEM106Btransmembrane protein 106BVery often (80–99%)In 1 condition
TREM2triggering receptor expressed on myeloid cells 2Very often (80–99%)In 1 condition
VCPvalosin containing proteinVery often (80–99%)In 2 conditions
ADARB1adenosine deaminase RNA specific B1Sometimes (5–29%)In 1 condition
COG1component of oligomeric golgi complex 1Sometimes (5–29%)In 1 condition
CYB5Acytochrome b5 type ASometimes (5–29%)In 1 condition
CYB5R3cytochrome b5 reductase 3Sometimes (5–29%)In 1 condition
OPHN1oligophrenin 1Sometimes (5–29%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Decrease in size of the outer layer of the brain due to loss of brain cells

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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