Trait
Wasting syndrome
Clinical name: Cachexia
Severe weight loss, wasting of muscle, loss of appetite, and general debility related to a chronic disease.
Summary
- Body system
- Growth abnormality
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test108 genes linked to Wasting syndrome
Changes in these genes cause rare conditions in which Wasting syndrome is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Always | In 2 conditions |
| POLGDNA polymerase gamma, catalytic subunit | Always | In 3 conditions |
| RFC4replication factor C subunit 4 | Always | In 1 condition |
| UNC80unc-80 subunit of NALCN channel complex | Always | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Very often (80–99%) | In 1 condition |
| ATRATR checkpoint kinase | Very often (80–99%) | In 1 condition |
| ATRIPATR interacting protein | Very often (80–99%) | In 1 condition |
| CD4CD4 molecule | Very often (80–99%) | In 1 condition |
| CENPEcentromere protein E | Very often (80–99%) | In 1 condition |
| CEP152centrosomal protein 152 | Very often (80–99%) | In 1 condition |
| CEP295centrosomal protein 295 | Very often (80–99%) | In 1 condition |
| CEP63centrosomal protein 63 | Very often (80–99%) | In 1 condition |
| CPAPcentrosome assembly and centriole elongation protein | Very often (80–99%) | In 1 condition |
| DNA2DNA replication helicase/nuclease 2 | Very often (80–99%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Very often (80–99%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Very often (80–99%) | In 1 condition |
| ERCC5ERCC excision repair 5, endonuclease | Very often (80–99%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Very often (80–99%) | In 1 condition |
| LIG3DNA ligase 3 | Very often (80–99%) | In 1 condition |
| LPIN2lipin 2 | Very often (80–99%) | In 1 condition |
| MAFBMAF bZIP transcription factor B | Very often (80–99%) | In 1 condition |
| NBNnibrin | Very often (80–99%) | In 1 condition |
| NINninein | Very often (80–99%) | In 1 condition |
| NSMCE2NSE2 SUMO ligase component of SMC5/6 complex | Very often (80–99%) | In 1 condition |
| NUP85nucleoporin 85 | Very often (80–99%) | In 1 condition |
| PCNTpericentrin | Very often (80–99%) | In 1 condition |
| PLK4polo like kinase 4 | Very often (80–99%) | In 1 condition |
| RBBP8RB binding protein 8, endonuclease | Very often (80–99%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Very often (80–99%) | In 2 conditions |
| SLC9A6solute carrier family 9 member A6 | Very often (80–99%) | In 1 condition |
| SUCLA2succinate-CoA ligase ADP-forming subunit beta | Very often (80–99%) | In 1 condition |
| TGFB1transforming growth factor beta 1 | Very often (80–99%) | In 1 condition |
| TRAIPTRAF interacting protein | Very often (80–99%) | In 1 condition |
| TRIM37tripartite motif containing 37 | Very often (80–99%) | In 1 condition |
| TRPV4transient receptor potential cation channel subfamily V member 4 | Very often (80–99%) | In 1 condition |
| TSHZ3teashirt zinc finger homeobox 3 | Very often (80–99%) | In 1 condition |
| TYMPthymidine phosphorylase | Very often (80–99%) | In 2 conditions |
| BMPR1Abone morphogenetic protein receptor type 1A | Often (30–79%) | In 1 condition |
| CUL4Bcullin 4B | Often (30–79%) | In 1 condition |
| LIPAlipase A, lysosomal acid type | Often (30–79%) | In 1 condition |
Show 68 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| PTENphosphatase and tensin homolog | Often (30–79%) | In 2 conditions |
| RRM1ribonucleotide reductase catalytic subunit M1 | Often (30–79%) | In 1 condition |
| SLC6A8solute carrier family 6 member 8 | Often (30–79%) | In 1 condition |
| VPS13Cvacuolar protein sorting 13 homolog C | Often (30–79%) | In 1 condition |
| ACADMacyl-CoA dehydrogenase medium chain | Sometimes (5–29%) | In 1 condition |
| ALS2alsin Rho guanine nucleotide exchange factor ALS2 | Sometimes (5–29%) | In 1 condition |
| ANGangiogenin | Sometimes (5–29%) | In 1 condition |
| ANXA11annexin A11 | Sometimes (5–29%) | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Sometimes (5–29%) | In 1 condition |
| ATXN2ataxin 2 | Sometimes (5–29%) | In 1 condition |
| CCNFcyclin F | Sometimes (5–29%) | In 1 condition |
| CFAP410cilia and flagella associated protein 410 | Sometimes (5–29%) | In 1 condition |
| CFTRCF transmembrane conductance regulator | Sometimes (5–29%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Sometimes (5–29%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Sometimes (5–29%) | In 1 condition |
| DAOD-amino acid oxidase | Sometimes (5–29%) | In 1 condition |
| DCTN1dynactin subunit 1 | Sometimes (5–29%) | In 1 condition |
| ERBB4erb-b2 receptor tyrosine kinase 4 | Sometimes (5–29%) | In 1 condition |
| ERLIN1ER lipid raft associated 1 | Sometimes (5–29%) | In 1 condition |
| EWSR1EWS RNA binding protein 1 | Sometimes (5–29%) | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Sometimes (5–29%) | In 1 condition |
| FOXP3forkhead box P3 | Sometimes (5–29%) | In 1 condition |
| FUSFUS RNA binding protein | Sometimes (5–29%) | In 2 conditions |
| GALCgalactosylceramidase | Sometimes (5–29%) | In 1 condition |
| GFAPglial fibrillary acidic protein | Sometimes (5–29%) | In 1 condition |
| GLE1GLE1 RNA export mediator | Sometimes (5–29%) | In 1 condition |
| GLT8D1glycosyltransferase 8 domain containing 1 | Sometimes (5–29%) | In 1 condition |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Sometimes (5–29%) | In 1 condition |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Sometimes (5–29%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Sometimes (5–29%) | In 1 condition |
| LMNAlamin A/C | Sometimes (5–29%) | In 1 condition |
| LRP12LDL receptor related protein 12 | Sometimes (5–29%) | In 1 condition |
| MATR3matrin 3 | Sometimes (5–29%) | In 1 condition |
| NDPnorrin cystine knot growth factor NDP | Sometimes (5–29%) | In 1 condition |
| NEFHneurofilament heavy chain | Sometimes (5–29%) | In 1 condition |
| NEK1NIMA related kinase 1 | Sometimes (5–29%) | In 1 condition |
| OPTNoptineurin | Sometimes (5–29%) | In 1 condition |
| PFN1profilin 1 | Sometimes (5–29%) | In 1 condition |
| PRPHperipherin | Sometimes (5–29%) | In 1 condition |
| PSAPprosaposin | Sometimes (5–29%) | In 1 condition |
| SCNN1Asodium channel epithelial 1 subunit alpha | Sometimes (5–29%) | In 1 condition |
| SCNN1Bsodium channel epithelial 1 subunit beta | Sometimes (5–29%) | In 1 condition |
| SCNN1Gsodium channel epithelial 1 subunit gamma | Sometimes (5–29%) | In 1 condition |
| SIGMAR1sigma receptor chaperone 1 | Sometimes (5–29%) | In 1 condition |
| SOD1superoxide dismutase 1 | Sometimes (5–29%) | In 1 condition |
| SORDsorbitol dehydrogenase | Sometimes (5–29%) | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Sometimes (5–29%) | In 1 condition |
| SPTLC1serine palmitoyltransferase long chain base subunit 1 | Sometimes (5–29%) | In 1 condition |
| SPTLC2serine palmitoyltransferase long chain base subunit 2 | Sometimes (5–29%) | In 1 condition |
| SQSTM1sequestosome 1 | Sometimes (5–29%) | In 1 condition |
| STUB1STIP1 homology and U-box containing protein 1 | Sometimes (5–29%) | In 1 condition |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Sometimes (5–29%) | In 1 condition |
| TAF15TATA-box binding protein associated factor 15 | Sometimes (5–29%) | In 1 condition |
| TARDBPTAR DNA binding protein | Sometimes (5–29%) | In 2 conditions |
| TBK1TANK binding kinase 1 | Sometimes (5–29%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Sometimes (5–29%) | In 1 condition |
| TRMT2BtRNA methyltransferase 2B | Sometimes (5–29%) | In 1 condition |
| UBQLN2ubiquilin 2 | Sometimes (5–29%) | In 2 conditions |
| UNC13Aunc-13 homolog A | Sometimes (5–29%) | In 1 condition |
| VAPBVAMP associated protein B and C | Sometimes (5–29%) | In 1 condition |
| VCPvalosin containing protein | Sometimes (5–29%) | In 1 condition |
| WT1WT1 transcription factor | Sometimes (5–29%) | In 1 condition |
| CALRcalreticulin | Rarely (1–4%) | In 1 condition |
| JAK2Janus kinase 2 | Rarely (1–4%) | In 1 condition |
| MPLMPL proto-oncogene, thrombopoietin receptor | Rarely (1–4%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Rarely (1–4%) | In 1 condition |
| CNTNAP1contactin associated protein 1 | Not recorded | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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