Trait
Muscle ache
Clinical name: Myalgia
Pain in muscle.
Summary
- Also called
- Muscle pain
- Body system
- Constitutional symptom
Reference genomeGRCh38hg38
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Get my Genome Test176 genes linked to Muscle ache
Changes in these genes cause rare conditions in which Muscle ache is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Always | In 1 condition |
| CR2complement C3d receptor 2 | Always | In 1 condition |
| FDX2ferredoxin 2 | Always | In 1 condition |
| GKglycerol kinase | Always | In 1 condition |
| HMGCR3-hydroxy-3-methylglutaryl-CoA reductase | Always | In 1 condition |
| JPH1junctophilin 1 | Always | In 1 condition |
| KYkyphoscoliosis peptidase | Always | In 1 condition |
| LPIN1lipin 1 | Always | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Always | In 5 conditions |
| MIEF2mitochondrial elongation factor 2 | Always | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Always | In 1 condition |
| POLG2DNA polymerase gamma 2, accessory subunit | Always | In 2 conditions |
| RTN2reticulon 2 | Always | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Always | In 7 conditions |
| SLC25A4solute carrier family 25 member 4 | Always | In 2 conditions |
| AMPD1adenosine monophosphate deaminase 1 | Very often (80–99%) | In 1 condition |
| AMPD3adenosine monophosphate deaminase 3 | Very often (80–99%) | In 1 condition |
| ANO5anoctamin 5 | Very often (80–99%) | In 2 conditions |
| C4Acomplement C4A (Chido/Rodgers blood group) | Very often (80–99%) | In 1 condition |
| CASQ1calsequestrin 1 | Very often (80–99%) | In 2 conditions |
| CCR1C-C motif chemokine receptor 1 | Very often (80–99%) | In 1 condition |
| CNBPCCHC-type zinc finger nucleic acid binding protein | Very often (80–99%) | In 2 conditions |
| CPT2carnitine palmitoyltransferase 2 | Very often (80–99%) | In 3 conditions |
| DMDdystrophin | Very often (80–99%) | In 3 conditions |
| DTNAdystrobrevin alpha | Very often (80–99%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Very often (80–99%) | In 1 condition |
| FASFas cell surface death receptor | Very often (80–99%) | In 1 condition |
| GLAgalactosidase alpha | Very often (80–99%) | In 1 condition |
| GYS1glycogen synthase 1 | Very often (80–99%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Very often (80–99%) | In 3 conditions |
| IFNGR1interferon gamma receptor 1 | Very often (80–99%) | In 1 condition |
| IL10interleukin 10 | Very often (80–99%) | In 1 condition |
| IL12Ainterleukin 12A | Very often (80–99%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Very often (80–99%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Very often (80–99%) | In 1 condition |
| KLRC4killer cell lectin like receptor C4 | Very often (80–99%) | In 1 condition |
| LBRlamin B receptor | Very often (80–99%) | In 1 condition |
| MVKmevalonate kinase | Very often (80–99%) | In 2 conditions |
| NLRP3NLR family pyrin domain containing 3 | Very often (80–99%) | In 5 conditions |
| OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | Very often (80–99%) | In 1 condition |
Show 136 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ORAI1ORAI calcium release-activated calcium modulator 1 | Very often (80–99%) | In 1 condition |
| PLAAT3phospholipase A and acyltransferase 3 | Very often (80–99%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Very often (80–99%) | In 2 conditions |
| STIM1stromal interaction molecule 1 | Very often (80–99%) | In 2 conditions |
| TLR4toll like receptor 4 | Very often (80–99%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Very often (80–99%) | In 2 conditions |
| UBAC2UBA domain containing 2 | Very often (80–99%) | In 1 condition |
| ACAD9acyl-CoA dehydrogenase family member 9 | Often (30–79%) | In 1 condition |
| ADA2adenosine deaminase 2 | Often (30–79%) | In 1 condition |
| ALDOAaldolase, fructose-bisphosphate A | Often (30–79%) | In 1 condition |
| APCAPC regulator of Wnt signaling pathway | Often (30–79%) | In 1 condition |
| ARVCFARVCF delta catenin family member | Often (30–79%) | In 1 condition |
| CCDC78coiled-coil domain containing 78 | Often (30–79%) | In 1 condition |
| CD4CD4 molecule | Often (30–79%) | In 1 condition |
| CLCN1chloride voltage-gated channel 1 | Often (30–79%) | In 3 conditions |
| COMTcatechol-O-methyltransferase | Often (30–79%) | In 1 condition |
| CRPPACDP-L-ribitol pyrophosphorylase A | Often (30–79%) | In 2 conditions |
| CTNNB1catenin beta 1 | Often (30–79%) | In 1 condition |
| DNA2DNA replication helicase/nuclease 2 | Often (30–79%) | In 2 conditions |
| ENO3enolase 3 | Often (30–79%) | In 2 conditions |
| FKRPfukutin related protein | Often (30–79%) | In 3 conditions |
| FKTNfukutin | Often (30–79%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Often (30–79%) | In 1 condition |
| HADHBhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | Often (30–79%) | In 2 conditions |
| HIRAhistone cell cycle regulator | Often (30–79%) | In 1 condition |
| IL12Binterleukin 12B | Often (30–79%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Often (30–79%) | In 1 condition |
| JMJD1Cjumonji domain containing 1C | Often (30–79%) | In 1 condition |
| LPIN2lipin 2 | Often (30–79%) | In 1 condition |
| MDM4MDM4 regulator of p53 | Often (30–79%) | In 1 condition |
| MLXMAX dimerization protein MLX | Often (30–79%) | In 1 condition |
| MOCOSmolybdenum cofactor sulfurase | Often (30–79%) | In 1 condition |
| MRPS2mitochondrial ribosomal protein S2 | Often (30–79%) | In 1 condition |
| MSTO1misato mitochondrial distribution and morphology regulator 1 | Often (30–79%) | In 2 conditions |
| MTTPmicrosomal triglyceride transfer protein | Often (30–79%) | In 1 condition |
| MYH7myosin heavy chain 7 | Often (30–79%) | In 2 conditions |
| NLRC4NLR family CARD domain containing 4 | Often (30–79%) | In 1 condition |
| NLRP12NLR family pyrin domain containing 12 | Often (30–79%) | In 1 condition |
| NOD2nucleotide binding oligomerization domain containing 2 | Often (30–79%) | In 1 condition |
| OTULINOTU deubiquitinase with linear linkage specificity | Often (30–79%) | In 1 condition |
| PACSIN3protein kinase C and casein kinase substrate in neurons 3 | Often (30–79%) | In 1 condition |
| PFKMphosphofructokinase, muscle | Often (30–79%) | In 1 condition |
| PGAM2phosphoglycerate mutase 2 | Often (30–79%) | In 1 condition |
| PHKA1phosphorylase kinase regulatory subunit alpha 1 | Often (30–79%) | In 1 condition |
| PHKG1phosphorylase kinase catalytic subunit gamma 1 | Often (30–79%) | In 1 condition |
| PNPLA2patatin like domain 2, triacylglycerol lipase | Often (30–79%) | In 2 conditions |
| POLR3ARNA polymerase III subunit A | Often (30–79%) | In 1 condition |
| POMT1protein O-mannosyltransferase 1 | Often (30–79%) | In 1 condition |
| PRDM5PR/SET domain 5 | Often (30–79%) | In 1 condition |
| PTPN6protein tyrosine phosphatase non-receptor type 6 | Often (30–79%) | In 1 condition |
| RNASEH1ribonuclease H1 | Often (30–79%) | In 2 conditions |
| RREB1ras responsive element binding protein 1 | Often (30–79%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Often (30–79%) | In 2 conditions |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Often (30–79%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Often (30–79%) | In 1 condition |
| SH3TC2SH3 domain and tetratricopeptide repeats 2 | Often (30–79%) | In 1 condition |
| SVILsupervillin | Often (30–79%) | In 1 condition |
| TBX1T-box transcription factor 1 | Often (30–79%) | In 1 condition |
| TRAPPC11trafficking protein particle complex subunit 11 | Often (30–79%) | In 3 conditions |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Often (30–79%) | In 1 condition |
| VCPvalosin containing protein | Often (30–79%) | In 1 condition |
| VWA1von Willebrand factor A domain containing 1 | Often (30–79%) | In 1 condition |
| ACP5acid phosphatase 5, tartrate resistant | Sometimes (5–29%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Sometimes (5–29%) | In 1 condition |
| ALDH4A1aldehyde dehydrogenase 4 family member A1 | Sometimes (5–29%) | In 1 condition |
| ANK1ankyrin 1 | Sometimes (5–29%) | In 1 condition |
| ANKRD55ankyrin repeat domain 55 | Sometimes (5–29%) | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Sometimes (5–29%) | In 1 condition |
| CAVIN1caveolae associated protein 1 | Sometimes (5–29%) | In 1 condition |
| CD247CD247 molecule | Sometimes (5–29%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Sometimes (5–29%) | In 1 condition |
| DCCDCC netrin 1 receptor | Sometimes (5–29%) | In 1 condition |
| DGUOKdeoxyguanosine kinase | Sometimes (5–29%) | In 1 condition |
| DNAJB6DnaJ heat shock protein family (Hsp40) member B6 | Sometimes (5–29%) | In 1 condition |
| DNAL4dynein axonemal light chain 4 | Sometimes (5–29%) | In 1 condition |
| DNASE1L3deoxyribonuclease 1L3 | Sometimes (5–29%) | In 1 condition |
| DYSFdysferlin | Sometimes (5–29%) | In 1 condition |
| EPB42erythrocyte membrane protein band 4.2 | Sometimes (5–29%) | In 1 condition |
| EXT1exostosin glycosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| EXT2exostosin glycosyltransferase 2 | Sometimes (5–29%) | In 1 condition |
| FMR1fragile X messenger ribonucleoprotein 1 | Sometimes (5–29%) | In 2 conditions |
| GPR101G protein-coupled receptor 101 | Sometimes (5–29%) | In 1 condition |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Sometimes (5–29%) | In 2 conditions |
| HLA-DPA1major histocompatibility complex, class II, DP alpha 1 | Sometimes (5–29%) | In 1 condition |
| HLA-DPB1major histocompatibility complex, class II, DP beta 1 | Sometimes (5–29%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 1 condition |
| HPDL4-hydroxyphenylpyruvate dioxygenase like | Sometimes (5–29%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Sometimes (5–29%) | In 1 condition |
| IGHG2immunoglobulin heavy constant gamma 2 (G2m marker) | Sometimes (5–29%) | In 1 condition |
| IGKCimmunoglobulin kappa constant | Sometimes (5–29%) | In 1 condition |
| IL2RAinterleukin 2 receptor subunit alpha | Sometimes (5–29%) | In 1 condition |
| IL2RBinterleukin 2 receptor subunit beta | Sometimes (5–29%) | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| LMNAlamin A/C | Sometimes (5–29%) | In 3 conditions |
| LMNB1lamin B1 | Sometimes (5–29%) | In 1 condition |
| LRP12LDL receptor related protein 12 | Sometimes (5–29%) | In 1 condition |
| MT-TEmitochondrially encoded tRNA-Glu (GAA/G) | Sometimes (5–29%) | In 1 condition |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Sometimes (5–29%) | In 1 condition |
| NTN1netrin 1 | Sometimes (5–29%) | In 1 condition |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| PHKA2phosphorylase kinase regulatory subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| PHKBphosphorylase kinase regulatory subunit beta | Sometimes (5–29%) | In 1 condition |
| PHKG2phosphorylase kinase catalytic subunit gamma 2 | Sometimes (5–29%) | In 1 condition |
| PLD4phospholipase D family member 4 | Sometimes (5–29%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| PPARGperoxisome proliferator activated receptor gamma | Sometimes (5–29%) | In 1 condition |
| PRORPprotein only RNase P catalytic subunit | Sometimes (5–29%) | In 1 condition |
| PRTN3proteinase 3 | Sometimes (5–29%) | In 1 condition |
| PTPN2protein tyrosine phosphatase non-receptor type 2 | Sometimes (5–29%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Sometimes (5–29%) | In 3 conditions |
| RAD51RAD51 recombinase | Sometimes (5–29%) | In 1 condition |
| SLC4A1solute carrier family 4 member 1 (Diego blood group) | Sometimes (5–29%) | In 1 condition |
| SPTA1spectrin alpha, erythrocytic 1 | Sometimes (5–29%) | In 1 condition |
| SPTBspectrin beta, erythrocytic | Sometimes (5–29%) | In 1 condition |
| SRSF2serine and arginine rich splicing factor 2 | Sometimes (5–29%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Sometimes (5–29%) | In 1 condition |
| TNXBtenascin XB | Sometimes (5–29%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Sometimes (5–29%) | In 2 conditions |
| ALMS1ALMS1 centrosome and basal body associated protein | Rarely (1–4%) | In 1 condition |
| CAV3caveolin 3 | Rarely (1–4%) | In 2 conditions |
| CLCNKBchloride voltage-gated channel Kb | Rarely (1–4%) | In 1 condition |
| DNM1Ldynamin 1L | Rarely (1–4%) | In 1 condition |
| FLNCfilamin C | Rarely (1–4%) | In 1 condition |
| OPA1OPA1 mitochondrial dynamin like GTPase | Rarely (1–4%) | In 1 condition |
| PPIBpeptidylprolyl isomerase B | Rarely (1–4%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Rarely (1–4%) | In 1 condition |
| CAPN3calpain 3 | Not recorded | In 1 condition |
| COX6B1cytochrome c oxidase subunit 6B1 | Not recorded | In 1 condition |
| DSEdermatan sulfate epimerase | Not recorded | In 1 condition |
| LDHAlactate dehydrogenase A | Not recorded | In 1 condition |
| MYOTmyotilin | Not recorded | In 1 condition |
| PDGFRAplatelet derived growth factor receptor alpha | Not recorded | In 1 condition |
| POPDC1popeye domain cAMP effector 1 | Not recorded | In 1 condition |
| RBCK1RANBP2-type and C3HC4-type zinc finger containing 1 | Not recorded | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Not recorded | In 1 condition |
| TMEM126Btransmembrane protein 126B | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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