Trait
Ongoing loss of nerve cells
Clinical name: Neurodegeneration
Progressive loss of neural cells and tissue.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Ongoing loss of nerve cells, and the rest of your genome, with one test.
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Get my Genome Test69 genes linked to Ongoing loss of nerve cells
Changes in these genes cause rare conditions in which Ongoing loss of nerve cells is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| EIF4A2eukaryotic translation initiation factor 4A2 | Always | In 1 condition |
| FTH1ferritin heavy chain 1 | Always | In 1 condition |
| NAE1NEDD8 activating enzyme E1 subunit 1 | Always | In 1 condition |
| PCNAproliferating cell nuclear antigen | Always | In 2 conditions |
| ANGangiogenin | Very often (80–99%) | In 1 condition |
| ANXA11annexin A11 | Very often (80–99%) | In 1 condition |
| ATXN2ataxin 2 | Very often (80–99%) | In 1 condition |
| CCNFcyclin F | Very often (80–99%) | In 1 condition |
| CFAP410cilia and flagella associated protein 410 | Very often (80–99%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Very often (80–99%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Very often (80–99%) | In 1 condition |
| DAOD-amino acid oxidase | Very often (80–99%) | In 1 condition |
| DCTN1dynactin subunit 1 | Very often (80–99%) | In 1 condition |
| ERBB4erb-b2 receptor tyrosine kinase 4 | Very often (80–99%) | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Very often (80–99%) | In 1 condition |
| FUSFUS RNA binding protein | Very often (80–99%) | In 1 condition |
| GLE1GLE1 RNA export mediator | Very often (80–99%) | In 1 condition |
| GLT8D1glycosyltransferase 8 domain containing 1 | Very often (80–99%) | In 1 condition |
| GM2Aganglioside GM2 activator | Very often (80–99%) | In 2 conditions |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Very often (80–99%) | In 1 condition |
| LRP12LDL receptor related protein 12 | Very often (80–99%) | In 1 condition |
| MATR3matrin 3 | Very often (80–99%) | In 1 condition |
| NEFHneurofilament heavy chain | Very often (80–99%) | In 1 condition |
| NEK1NIMA related kinase 1 | Very often (80–99%) | In 1 condition |
| OPTNoptineurin | Very often (80–99%) | In 1 condition |
| PFN1profilin 1 | Very often (80–99%) | In 1 condition |
| PRPHperipherin | Very often (80–99%) | In 1 condition |
| SOD1superoxide dismutase 1 | Very often (80–99%) | In 1 condition |
| SQSTM1sequestosome 1 | Very often (80–99%) | In 1 condition |
| TAF15TATA-box binding protein associated factor 15 | Very often (80–99%) | In 1 condition |
| TARDBPTAR DNA binding protein | Very often (80–99%) | In 1 condition |
| TBK1TANK binding kinase 1 | Very often (80–99%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Very often (80–99%) | In 1 condition |
| TXN2thioredoxin 2 | Very often (80–99%) | In 1 condition |
| UBQLN2ubiquilin 2 | Very often (80–99%) | In 1 condition |
| UNC13Aunc-13 homolog A | Very often (80–99%) | In 1 condition |
| VAPBVAMP associated protein B and C | Very often (80–99%) | In 1 condition |
| VCPvalosin containing protein | Very often (80–99%) | In 1 condition |
| DLATdihydrolipoamide S-acetyltransferase | Often (30–79%) | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Often (30–79%) | In 1 condition |
Show 29 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| HSD17B10hydroxysteroid 17-beta dehydrogenase 10 | Often (30–79%) | In 1 condition |
| IDSiduronate 2-sulfatase | Often (30–79%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| AARS2alanyl-tRNA synthetase 2, mitochondrial | Not recorded | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Not recorded | In 1 condition |
| C19orf12chromosome 19 open reading frame 12 | Not recorded | In 1 condition |
| COASYCoenzyme A synthase | Not recorded | In 1 condition |
| COQ2coenzyme Q2, polyprenyltransferase | Not recorded | In 1 condition |
| CSF1Rcolony stimulating factor 1 receptor | Not recorded | In 1 condition |
| FA2Hfatty acid 2-hydroxylase | Not recorded | In 1 condition |
| FOLR1folate receptor alpha | Not recorded | In 1 condition |
| FTLferritin light chain | Not recorded | In 1 condition |
| GALCgalactosylceramidase | Not recorded | In 1 condition |
| GUSBglucuronidase beta | Not recorded | In 1 condition |
| IDUAalpha-L-iduronidase | Not recorded | In 1 condition |
| LYSTlysosomal trafficking regulator | Not recorded | In 1 condition |
| MFSD8major facilitator superfamily domain containing 8 | Not recorded | In 1 condition |
| NARS2asparaginyl-tRNA synthetase 2, mitochondrial | Not recorded | In 1 condition |
| NAXDNAD(P)HX dehydratase | Not recorded | In 1 condition |
| NBNnibrin | Not recorded | In 1 condition |
| PANK2pantothenate kinase 2 | Not recorded | In 1 condition |
| PLA2G6phospholipase A2 group VI | Not recorded | In 2 conditions |
| PRNPprion protein (Kanno blood group) | Not recorded | In 1 condition |
| TANGO2transport and golgi organization 2 homolog | Not recorded | In 1 condition |
| TTC19tetratricopeptide repeat domain 19 | Not recorded | In 1 condition |
| UBTFupstream binding transcription factor | Not recorded | In 1 condition |
| UCHL1ubiquitin C-terminal hydrolase L1 | Not recorded | In 1 condition |
| WDR45WD repeat domain 45 | Not recorded | In 1 condition |
| ZBTB20zinc finger and BTB domain containing 20 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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