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Trait

Bulbar palsy

Bulbar weakness (or bulbar palsy) refers to bilateral impairment of function of the lower cranial nerves IX, X, XI and XII, which occurs due to lower motor neuron lesion either at nuclear or fascicular level in the medulla or from bilateral lesions of the lower cranial nerves outside the brain-stem. Bulbar weakness is often associated with difficulty in chewing, weakness of the facial muscles, dysarthria, palatal weakness and regurgitation of fluids, dysphagia, and dysphonia.

HPO HP:0001283

Summary

Also called
Bulbar muscle weakness, Bulbar palsies, Bulbar weakness
Body system
Abnormality of the musculoskeletal systemAbnormality of the nervous system

36 genes linked to Bulbar palsy

Changes in these genes cause rare conditions in which Bulbar palsy is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
CHATcholine O-acetyltransferaseAlwaysIn 1 condition
GIPC1GIPC PDZ domain containing family member 1AlwaysIn 1 condition
LMOD3leiomodin 3AlwaysIn 1 condition
PLAAphospholipase A2 activating proteinAlwaysIn 2 conditions
COL13A1collagen type XIII alpha 1 chainOften (30–79%)In 1 condition
MATR3matrin 3Often (30–79%)In 2 conditions
SLC25A1solute carrier family 25 member 1Often (30–79%)In 1 condition
SLC52A3solute carrier family 52 member 3Often (30–79%)In 2 conditions
TIA1TIA1 cytotoxic granule associated RNA binding proteinOften (30–79%)In 1 condition
BICD2BICD cargo adaptor 2Sometimes (5–29%)In 1 condition
CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10Sometimes (5–29%)In 2 conditions
DNAJB6DnaJ heat shock protein family (Hsp40) member B6Sometimes (5–29%)In 1 condition
FUSFUS RNA binding proteinSometimes (5–29%)In 1 condition
HK1hexokinase 1Sometimes (5–29%)In 1 condition
HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1Sometimes (5–29%)In 1 condition
MTRFRmitochondrial translation release factor in rescueSometimes (5–29%)In 1 condition
PET100PET100 cytochrome c oxidase chaperoneSometimes (5–29%)In 1 condition
SQSTM1sequestosome 1Sometimes (5–29%)In 2 conditions
TARDBPTAR DNA binding proteinSometimes (5–29%)In 1 condition
TBK1TANK binding kinase 1Sometimes (5–29%)In 2 conditions
VCPvalosin containing proteinSometimes (5–29%)In 1 condition
ABCD1ATP binding cassette subfamily D member 1Not recordedIn 1 condition
ACTA1actin alpha 1, skeletal muscleNot recordedIn 1 condition
ARandrogen receptorNot recordedIn 1 condition
ARSAarylsulfatase ANot recordedIn 1 condition
ATXN1ataxin 1Not recordedIn 1 condition
CHRNA1cholinergic receptor nicotinic alpha 1 subunitNot recordedIn 1 condition
CHRNEcholinergic receptor nicotinic epsilon subunitNot recordedIn 1 condition
DESdesminNot recordedIn 1 condition
DOK7docking protein 7Not recordedIn 1 condition
GSNgelsolinNot recordedIn 1 condition
NEBnebulinNot recordedIn 1 condition
SLC52A2solute carrier family 52 member 2Not recordedIn 1 condition
SLC5A7solute carrier family 5 member 7Not recordedIn 1 condition
TPM3tropomyosin 3Not recordedIn 1 condition
TRPM7transient receptor potential cation channel subfamily M member 7Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal nervous system physiologyMuscle weakness

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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