Trait
Worsening neurological symptoms
Clinical name: Progressive neurologic deterioration
Summary
- Also called
- Neurologic deterioration, Neurologic deterioration, progressive, Progressive mental deterioration, Progressive neurodegeneration
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test59 genes linked to Worsening neurological symptoms
Changes in these genes cause rare conditions in which Worsening neurological symptoms is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CERS1ceramide synthase 1 | Always | In 1 condition |
| EIF2B5eukaryotic translation initiation factor 2B subunit epsilon | Always | In 1 condition |
| KARS1lysyl-tRNA synthetase 1 | Always | In 1 condition |
| MICOS13mitochondrial contact site and cristae organizing system subunit 13 | Always | In 1 condition |
| MTFMTmitochondrial methionyl-tRNA formyltransferase | Always | In 1 condition |
| PSAPprosaposin | Always | In 2 conditions |
| SLC13A3solute carrier family 13 member 3 | Always | In 1 condition |
| SYNJ1synaptojanin 1 | Always | In 1 condition |
| GALCgalactosylceramidase | Very often (80–99%) | In 2 conditions |
| HIBCH3-hydroxyisobutyryl-CoA hydrolase | Very often (80–99%) | In 1 condition |
| HSD17B10hydroxysteroid 17-beta dehydrogenase 10 | Very often (80–99%) | In 1 condition |
| NHLRC1NHL repeat containing E3 ubiquitin protein ligase 1 | Very often (80–99%) | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Often (30–79%) | In 1 condition |
| CMPK2cytidine/uridine monophosphate kinase 2 | Often (30–79%) | In 1 condition |
| CYC1cytochrome c1 | Often (30–79%) | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Often (30–79%) | In 2 conditions |
| HNF4Ahepatocyte nuclear factor 4 alpha | Often (30–79%) | In 1 condition |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| JAM2junctional adhesion molecule 2 | Often (30–79%) | In 1 condition |
| LRPPRCleucine rich pentatricopeptide repeat containing | Often (30–79%) | In 1 condition |
| MYORGmyogenesis regulating glycosidase | Often (30–79%) | In 1 condition |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Often (30–79%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Often (30–79%) | In 1 condition |
| PDGFRBplatelet derived growth factor receptor beta | Often (30–79%) | In 2 conditions |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 1 condition |
| RRP12ribosomal RNA processing 12 homolog | Often (30–79%) | In 1 condition |
| SLC20A2solute carrier family 20 member 2 | Often (30–79%) | In 1 condition |
| SMPD1sphingomyelin phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| VCPvalosin containing protein | Often (30–79%) | In 1 condition |
| XPR1xenotropic and polytropic retrovirus receptor 1 | Often (30–79%) | In 1 condition |
| ATP1A2ATPase Na+/K+ transporting subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| ATP1A3ATPase Na+/K+ transporting subunit alpha 3 | Sometimes (5–29%) | In 1 condition |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Sometimes (5–29%) | In 1 condition |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Sometimes (5–29%) | In 1 condition |
| MT-TL2mitochondrially encoded tRNA-Leu (CUN) 2 | Sometimes (5–29%) | In 1 condition |
| RAB27ARAB27A, member RAS oncogene family | Sometimes (5–29%) | In 1 condition |
| RHOBTB2Rho related BTB domain containing 2 | Sometimes (5–29%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Sometimes (5–29%) | In 1 condition |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Sometimes (5–29%) | In 1 condition |
| SLC1A3solute carrier family 1 member 3 | Sometimes (5–29%) | In 1 condition |
Show 19 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SLC2A1solute carrier family 2 member 1 | Sometimes (5–29%) | In 1 condition |
| SLC39A14solute carrier family 39 member 14 | Sometimes (5–29%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Sometimes (5–29%) | In 1 condition |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Rarely (1–4%) | In 1 condition |
| CTNScystinosin, lysosomal cystine transporter | Not recorded | In 1 condition |
| EPM2AEPM2A glucan phosphatase, laforin | Not recorded | In 1 condition |
| GBA1glucosylceramidase beta 1 | Not recorded | In 3 conditions |
| GCH1GTP cyclohydrolase 1 | Not recorded | In 1 condition |
| HEPACAMhepatic and glial cell adhesion molecule | Not recorded | In 1 condition |
| IDUAalpha-L-iduronidase | Not recorded | In 1 condition |
| ITM2Bintegral membrane protein 2B | Not recorded | In 1 condition |
| MCOLN1mucolipin TRP cation channel 1 | Not recorded | In 1 condition |
| NAGLUN-acetyl-alpha-glucosaminidase | Not recorded | In 1 condition |
| NDUFA6NADH:ubiquinone oxidoreductase subunit A6 | Not recorded | In 1 condition |
| PTS6-pyruvoyltetrahydropterin synthase | Not recorded | In 1 condition |
| QDPRquinoid dihydropteridine reductase | Not recorded | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Not recorded | In 1 condition |
| TIMMDC1translocase of inner mitochondrial membrane domain containing 1 | Not recorded | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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