Trait
Abnormal rhythmic movements of ankle
Clinical name: Ankle clonus
Clonus is an involuntary tendon reflex that causes repeated flexion and extension of the foot. Ankle clonus is tested by rapidly flexing the foot upward.
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Abnormal rhythmic movements of ankle, and the rest of your genome, with one test.
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Get my Genome Test64 genes linked to Abnormal rhythmic movements of ankle
Changes in these genes cause rare conditions in which Abnormal rhythmic movements of ankle is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AHDC1AT-hook DNA binding motif containing 1 | Always | In 1 condition |
| COQ4coenzyme Q4 | Always | In 1 condition |
| CYP27A1cytochrome P450 family 27 subfamily A member 1 | Always | In 1 condition |
| GCSHglycine cleavage system protein H | Always | In 1 condition |
| MARS1methionyl-tRNA synthetase 1 | Always | In 1 condition |
| NDUFS8NADH:ubiquinone oxidoreductase core subunit S8 | Always | In 1 condition |
| NT5C25'-nucleotidase, cytosolic II | Always | In 1 condition |
| PEX1peroxisomal biogenesis factor 1 | Always | In 1 condition |
| PI4KAphosphatidylinositol 4-kinase alpha | Always | In 1 condition |
| RTN2reticulon 2 | Always | In 1 condition |
| SELENOIselenoprotein I | Always | In 2 conditions |
| SMG9SMG9 nonsense mediated mRNA decay factor | Always | In 1 condition |
| SOD1superoxide dismutase 1 | Always | In 1 condition |
| SPTBN2spectrin beta, non-erythrocytic 2 | Always | In 1 condition |
| ERLIN2ER lipid raft associated 2 | Very often (80–99%) | In 4 conditions |
| AARS1alanyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| ANO10anoctamin 10 | Often (30–79%) | In 1 condition |
| ATL1atlastin GTPase 1 | Often (30–79%) | In 1 condition |
| CAPN1calpain 1 | Often (30–79%) | In 2 conditions |
| CCDC88Ccoiled-coil and HOOK domain protein 88C | Often (30–79%) | In 1 condition |
| CYP7B1cytochrome P450 family 7 subfamily B member 1 | Often (30–79%) | In 1 condition |
| FA2Hfatty acid 2-hydroxylase | Often (30–79%) | In 2 conditions |
| GFM2GTP dependent ribosome recycling factor mitochondrial 2 | Often (30–79%) | In 2 conditions |
| KIF1Akinesin family member 1A | Often (30–79%) | In 2 conditions |
| KLC2kinesin light chain 2 | Often (30–79%) | In 1 condition |
| KPNA3karyopherin subunit alpha 3 | Often (30–79%) | In 1 condition |
| PLA2G6phospholipase A2 group VI | Often (30–79%) | In 1 condition |
| POU3F4POU class 3 homeobox 4 | Often (30–79%) | In 1 condition |
| REEP1receptor accessory protein 1 | Often (30–79%) | In 1 condition |
| SLC1A4solute carrier family 1 member 4 | Often (30–79%) | In 1 condition |
| SLC39A14solute carrier family 39 member 14 | Often (30–79%) | In 2 conditions |
| SPASTspastin | Often (30–79%) | In 1 condition |
| SV2Asynaptic vesicle glycoprotein 2A | Often (30–79%) | In 1 condition |
| TIMM8Atranslocase of inner mitochondrial membrane 8A | Often (30–79%) | In 1 condition |
| TUBA4Atubulin alpha 4a | Often (30–79%) | In 1 condition |
| VAC14VAC14 component of PIKFYVE complex | Often (30–79%) | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Sometimes (5–29%) | In 1 condition |
| ADGRG1adhesion G protein-coupled receptor G1 | Sometimes (5–29%) | In 1 condition |
| ATP6AP2ATPase H+ transporting accessory protein 2 | Sometimes (5–29%) | In 1 condition |
| CARS1cysteinyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
Show 24 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CD40LGCD40 ligand | Sometimes (5–29%) | In 1 condition |
| ERLIN1ER lipid raft associated 1 | Sometimes (5–29%) | In 1 condition |
| FGF13fibroblast growth factor 13 | Sometimes (5–29%) | In 1 condition |
| GALCgalactosylceramidase | Sometimes (5–29%) | In 1 condition |
| KIF1Ckinesin family member 1C | Sometimes (5–29%) | In 1 condition |
| NFU1NFU1 iron-sulfur cluster scaffold | Sometimes (5–29%) | In 1 condition |
| PEX16peroxisomal biogenesis factor 16 | Sometimes (5–29%) | In 1 condition |
| PSAPprosaposin | Sometimes (5–29%) | In 1 condition |
| RAB18RAB18, member RAS oncogene family | Sometimes (5–29%) | In 1 condition |
| SLC16A2solute carrier family 16 member 2 | Sometimes (5–29%) | In 1 condition |
| SLC52A3solute carrier family 52 member 3 | Sometimes (5–29%) | In 1 condition |
| SPARTspartin | Sometimes (5–29%) | In 2 conditions |
| STUB1STIP1 homology and U-box containing protein 1 | Sometimes (5–29%) | In 2 conditions |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Sometimes (5–29%) | In 1 condition |
| TCEAL1transcription elongation factor A like 1 | Sometimes (5–29%) | In 1 condition |
| VCPvalosin containing protein | Sometimes (5–29%) | In 1 condition |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Rarely (1–4%) | In 1 condition |
| KIF5Akinesin family member 5A | Rarely (1–4%) | In 2 conditions |
| GBA2glucosylceramidase beta 2 | Not recorded | In 1 condition |
| HTThuntingtin | Not recorded | In 1 condition |
| PIGTphosphatidylinositol glycan anchor biosynthesis class T | Not recorded | In 1 condition |
| SAMD9Lsterile alpha motif domain containing 9 like | Not recorded | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Not recorded | In 1 condition |
| UCHL1ubiquitin C-terminal hydrolase L1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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