Trait
Loss of expressive speech
Clinical name: Expressive aphasia
Impairment of expressive language and relative preservation of receptive language abilities. That is, the patient understands language (speech, writing) but cannot express it.
Summary
- Also called
- Non-fluent aphasia, Broca's aphasia, Motor aphasia
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Loss of expressive speech, and the rest of your genome, with one test.
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Get my Genome Test13 genes linked to Loss of expressive speech
Changes in these genes cause rare conditions in which Loss of expressive speech is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FA2Hfatty acid 2-hydroxylase | Often (30–79%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Sometimes (5–29%) | In 1 condition |
| DEPDC5DEP domain containing 5, GATOR1 subcomplex subunit | Sometimes (5–29%) | In 1 condition |
| GRNgranulin precursor | Sometimes (5–29%) | In 1 condition |
| MAPTmicrotubule associated protein tau | Sometimes (5–29%) | In 1 condition |
| NPRL2NPR2 like, GATOR1 complex subunit | Sometimes (5–29%) | In 1 condition |
| NPRL3NPR3 like, GATOR1 complex subunit | Sometimes (5–29%) | In 1 condition |
| PSEN1presenilin 1 | Sometimes (5–29%) | In 1 condition |
| SCN3Asodium voltage-gated channel alpha subunit 3 | Sometimes (5–29%) | In 1 condition |
| TMEM106Btransmembrane protein 106B | Sometimes (5–29%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Sometimes (5–29%) | In 1 condition |
| VCPvalosin containing protein | Sometimes (5–29%) | In 1 condition |
| GJB1gap junction protein beta 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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