Trait
Restlessness
A state of unease is characterized by diffuse motor activity or motion, which is subject to limited control, nonproductive, or disorganized behavior.
Summary
- Also called
- Fidgetiness, Restiveness
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test49 genes linked to Restlessness
Changes in these genes cause rare conditions in which Restlessness is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CCT3chaperonin containing TCP1 subunit 3 | Always | In 1 condition |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Always | In 1 condition |
| NGLY1N-glycanase 1 | Always | In 1 condition |
| PTRHD1peptidyl-tRNA hydrolase domain containing 1 | Always | In 1 condition |
| RNF13ring finger protein 13 | Always | In 2 conditions |
| RNU2-2RNA, U2 small nuclear 2 | Always | In 1 condition |
| SATB2SATB homeobox 2 | Always | In 2 conditions |
| UQCRQubiquinol-cytochrome c reductase complex III subunit VII | Always | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Very often (80–99%) | In 3 conditions |
| GRNgranulin precursor | Very often (80–99%) | In 2 conditions |
| MAPTmicrotubule associated protein tau | Very often (80–99%) | In 2 conditions |
| PSEN1presenilin 1 | Very often (80–99%) | In 2 conditions |
| SQSTM1sequestosome 1 | Very often (80–99%) | In 1 condition |
| TMEM106Btransmembrane protein 106B | Very often (80–99%) | In 2 conditions |
| TREM2triggering receptor expressed on myeloid cells 2 | Very often (80–99%) | In 2 conditions |
| VCPvalosin containing protein | Very often (80–99%) | In 2 conditions |
| CLCN3Cl-/H+ antiporter 3 | Often (30–79%) | In 1 condition |
| GNSglucosamine (N-acetyl)-6-sulfatase | Often (30–79%) | In 1 condition |
| HPD4-hydroxyphenylpyruvate dioxygenase | Often (30–79%) | In 1 condition |
| SLC19A3solute carrier family 19 member 3 | Often (30–79%) | In 1 condition |
| SLC25A13solute carrier family 25 member 13 | Often (30–79%) | In 1 condition |
| ALADaminolevulinate dehydratase | Sometimes (5–29%) | In 1 condition |
| ALDH7A1aldehyde dehydrogenase 7 family member A1 | Sometimes (5–29%) | In 1 condition |
| BCKDKbranched chain keto acid dehydrogenase kinase | Sometimes (5–29%) | In 1 condition |
| CTNNB1catenin beta 1 | Sometimes (5–29%) | In 1 condition |
| CTSHcathepsin H | Sometimes (5–29%) | In 1 condition |
| HCRThypocretin neuropeptide precursor | Sometimes (5–29%) | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Sometimes (5–29%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 1 condition |
| HMBShydroxymethylbilane synthase | Sometimes (5–29%) | In 1 condition |
| HSD17B10hydroxysteroid 17-beta dehydrogenase 10 | Sometimes (5–29%) | In 2 conditions |
| MED13Lmediator complex subunit 13L | Sometimes (5–29%) | In 1 condition |
| MOGmyelin oligodendrocyte glycoprotein | Sometimes (5–29%) | In 1 condition |
| NAXENAD(P)HX epimerase | Sometimes (5–29%) | In 1 condition |
| P2RY11purinergic receptor P2Y11 | Sometimes (5–29%) | In 1 condition |
| PAK3p21 (RAC1) activated kinase 3 | Sometimes (5–29%) | In 1 condition |
| PLPBPpyridoxal phosphate binding protein | Sometimes (5–29%) | In 1 condition |
| PRNPprion protein (Kanno blood group) | Sometimes (5–29%) | In 2 conditions |
| PTS6-pyruvoyltetrahydropterin synthase | Sometimes (5–29%) | In 1 condition |
Show 9 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SRCAPSnf2 related CREBBP activator protein | Sometimes (5–29%) | In 1 condition |
| TNFSF4TNF superfamily member 4 | Sometimes (5–29%) | In 1 condition |
| ZBTB20zinc finger and BTB domain containing 20 | Sometimes (5–29%) | In 1 condition |
| ZNF365zinc finger protein 365 | Sometimes (5–29%) | In 1 condition |
| PPP2R5Cprotein phosphatase 2 regulatory subunit B'gamma | Rarely (1–4%) | In 1 condition |
| CLN8CLN8 transmembrane ER and ERGIC protein | Not recorded | In 1 condition |
| GLDCglycine decarboxylase | Not recorded | In 1 condition |
| KDM5Clysine demethylase 5C | Not recorded | In 1 condition |
| TSEN54tRNA splicing endonuclease subunit 54 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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