Trait
High stepping
Clinical name: Steppage gait
An abnormal gait pattern that arises from weakness of the pretibial and peroneal muscles due to a lower motor neuron lesion. Affected patients have footdrop and are unable to dorsiflex and evert the foot. The leg is lifted high on walking so that the toes clear the ground, and there may be a slapping noise when the foot strikes the ground again.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to High stepping, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test97 genes linked to High stepping
Changes in these genes cause rare conditions in which High stepping is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DARS2aspartyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| HSPB3heat shock protein family B (small) member 3 | Always | In 1 condition |
| HSPB8heat shock protein family B (small) member 8 | Always | In 1 condition |
| MARS1methionyl-tRNA synthetase 1 | Always | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Always | In 1 condition |
| PDK3pyruvate dehydrogenase kinase 3 | Always | In 2 conditions |
| PLEKHG5pleckstrin homology and RhoGEF domain containing G5 | Always | In 1 condition |
| PPP2R5Cprotein phosphatase 2 regulatory subunit B'gamma | Always | In 1 condition |
| RAB7ARAB7A, member RAS oncogene family | Always | In 1 condition |
| SCO2synthesis of cytochrome C oxidase 2 | Always | In 2 conditions |
| SEL1LSEL1L adaptor subunit of SYVN1 ubiquitin ligase | Always | In 1 condition |
| SPTAN1spectrin alpha, non-erythrocytic 1 | Always | In 1 condition |
| TDP1tyrosyl-DNA phosphodiesterase 1 | Always | In 2 conditions |
| ARHGAP19Rho GTPase activating protein 19 | Very often (80–99%) | In 1 condition |
| HSPB1heat shock protein family B (small) member 1 | Very often (80–99%) | In 2 conditions |
| ATL1atlastin GTPase 1 | Often (30–79%) | In 1 condition |
| ATL3atlastin GTPase 3 | Often (30–79%) | In 1 condition |
| DNMT3BDNA methyltransferase 3 beta | Often (30–79%) | In 1 condition |
| DUX4double homeobox 4 | Often (30–79%) | In 1 condition |
| DUX4L1double homeobox 4 like 1 (pseudogene) | Often (30–79%) | In 1 condition |
| FRG1FSHD region gene 1 | Often (30–79%) | In 1 condition |
| GNB4G protein subunit beta 4 | Often (30–79%) | In 1 condition |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Often (30–79%) | In 1 condition |
| HARS1histidyl-tRNA synthetase 1 | Often (30–79%) | In 2 conditions |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Often (30–79%) | In 3 conditions |
| KLHL9kelch like family member 9 | Often (30–79%) | In 1 condition |
| LMNAlamin A/C | Often (30–79%) | In 2 conditions |
| MTRFRmitochondrial translation release factor in rescue | Often (30–79%) | In 1 condition |
| NEFLneurofilament light chain | Often (30–79%) | In 4 conditions |
| SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1 | Often (30–79%) | In 1 condition |
| SPTLC1serine palmitoyltransferase long chain base subunit 1 | Often (30–79%) | In 2 conditions |
| SPTLC2serine palmitoyltransferase long chain base subunit 2 | Often (30–79%) | In 1 condition |
| SQSTM1sequestosome 1 | Often (30–79%) | In 3 conditions |
| TIA1TIA1 cytotoxic granule associated RNA binding protein | Often (30–79%) | In 2 conditions |
| TTNtitin | Often (30–79%) | In 2 conditions |
| VAC14VAC14 component of PIKFYVE complex | Often (30–79%) | In 1 condition |
| ADSS1adenylosuccinate synthase 1 | Sometimes (5–29%) | In 1 condition |
| ANGangiogenin | Sometimes (5–29%) | In 1 condition |
| ANXA11annexin A11 | Sometimes (5–29%) | In 1 condition |
| ATXN2ataxin 2 | Sometimes (5–29%) | In 1 condition |
Show 57 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| BICD2BICD cargo adaptor 2 | Sometimes (5–29%) | In 1 condition |
| CCNFcyclin F | Sometimes (5–29%) | In 1 condition |
| CFAP410cilia and flagella associated protein 410 | Sometimes (5–29%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Sometimes (5–29%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Sometimes (5–29%) | In 1 condition |
| CLIC2CLIC family member 2 | Sometimes (5–29%) | In 1 condition |
| DAOD-amino acid oxidase | Sometimes (5–29%) | In 1 condition |
| DCTN1dynactin subunit 1 | Sometimes (5–29%) | In 1 condition |
| DHHdesert hedgehog signaling molecule | Sometimes (5–29%) | In 1 condition |
| ERBB4erb-b2 receptor tyrosine kinase 4 | Sometimes (5–29%) | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Sometimes (5–29%) | In 1 condition |
| FUSFUS RNA binding protein | Sometimes (5–29%) | In 1 condition |
| GLE1GLE1 RNA export mediator | Sometimes (5–29%) | In 1 condition |
| GLT8D1glycosyltransferase 8 domain containing 1 | Sometimes (5–29%) | In 1 condition |
| GRIN2Aglutamate ionotropic receptor NMDA type subunit 2A | Sometimes (5–29%) | In 1 condition |
| HINT1histidine triad nucleotide binding protein 1 | Sometimes (5–29%) | In 1 condition |
| LRP12LDL receptor related protein 12 | Sometimes (5–29%) | In 1 condition |
| MATR3matrin 3 | Sometimes (5–29%) | In 1 condition |
| MFN2mitofusin 2 | Sometimes (5–29%) | In 3 conditions |
| MTTPmicrosomal triglyceride transfer protein | Sometimes (5–29%) | In 1 condition |
| NEBnebulin | Sometimes (5–29%) | In 1 condition |
| NEFHneurofilament heavy chain | Sometimes (5–29%) | In 1 condition |
| NEK1NIMA related kinase 1 | Sometimes (5–29%) | In 1 condition |
| OPTNoptineurin | Sometimes (5–29%) | In 1 condition |
| PFN1profilin 1 | Sometimes (5–29%) | In 1 condition |
| PMP22peripheral myelin protein 22 | Sometimes (5–29%) | In 4 conditions |
| PRPHperipherin | Sometimes (5–29%) | In 1 condition |
| SBF2SET binding factor 2 | Sometimes (5–29%) | In 1 condition |
| SOD1superoxide dismutase 1 | Sometimes (5–29%) | In 1 condition |
| TAF15TATA-box binding protein associated factor 15 | Sometimes (5–29%) | In 1 condition |
| TARDBPTAR DNA binding protein | Sometimes (5–29%) | In 1 condition |
| TBK1TANK binding kinase 1 | Sometimes (5–29%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Sometimes (5–29%) | In 1 condition |
| UBQLN2ubiquilin 2 | Sometimes (5–29%) | In 1 condition |
| UNC13Aunc-13 homolog A | Sometimes (5–29%) | In 1 condition |
| VAPBVAMP associated protein B and C | Sometimes (5–29%) | In 1 condition |
| VCPvalosin containing protein | Sometimes (5–29%) | In 2 conditions |
| ATP1A1ATPase Na+/K+ transporting subunit alpha 1 | Not recorded | In 1 condition |
| COA7cytochrome c oxidase assembly factor 7 | Not recorded | In 1 condition |
| COX6A1cytochrome c oxidase subunit 6A1 | Not recorded | In 1 condition |
| DCAF8DDB1 and CUL4 associated factor 8 | Not recorded | In 1 condition |
| EGR2early growth response 2 | Not recorded | In 2 conditions |
| FHL1four and a half LIM domains 1 | Not recorded | In 1 condition |
| GANgigaxonin | Not recorded | In 1 condition |
| GBF1golgi brefeldin A resistant guanine nucleotide exchange factor 1 | Not recorded | In 1 condition |
| GDAP1ganglioside induced differentiation associated protein 1 | Not recorded | In 1 condition |
| IGHMBP2immunoglobulin mu DNA binding protein 2 | Not recorded | In 1 condition |
| INF2inverted formin 2 | Not recorded | In 1 condition |
| KARS1lysyl-tRNA synthetase 1 | Not recorded | In 1 condition |
| KIF1Bkinesin family member 1B | Not recorded | In 1 condition |
| LRSAM1leucine rich repeat and sterile alpha motif containing 1 | Not recorded | In 1 condition |
| MPZmyelin protein zero | Not recorded | In 4 conditions |
| PMP2peripheral myelin protein 2 | Not recorded | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Not recorded | In 1 condition |
| PRXperiaxin | Not recorded | In 2 conditions |
| SLC25A46solute carrier family 25 member 46 | Not recorded | In 1 condition |
| SLC30A10solute carrier family 30 member 10 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks