Trait
Paralysis
Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Motor paralysis results from deficits of the upper motor neurons (corticospinal, corticobulbar, or subcorticospinal). Motor paralysis is often accompanied by an impairment in the facility of movement.
Summary
- Also called
- Inability to move
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test61 genes linked to Paralysis
Changes in these genes cause rare conditions in which Paralysis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BORCS8BLOC-1 related complex subunit 8 | Always | In 1 condition |
| FDXRferredoxin reductase | Always | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Always | In 2 conditions |
| CACNA1Scalcium voltage-gated channel subunit alpha1 S | Very often (80–99%) | In 2 conditions |
| GABRA3gamma-aminobutyric acid type A receptor subunit alpha3 | Very often (80–99%) | In 1 condition |
| KCNE3potassium voltage-gated channel subfamily E regulatory subunit 3 | Very often (80–99%) | In 1 condition |
| KCNJ18potassium inwardly rectifying channel subfamily J member 18 | Very often (80–99%) | In 1 condition |
| ANGangiogenin | Often (30–79%) | In 1 condition |
| ANXA11annexin A11 | Often (30–79%) | In 1 condition |
| ATXN2ataxin 2 | Often (30–79%) | In 1 condition |
| CCNFcyclin F | Often (30–79%) | In 1 condition |
| CFAP410cilia and flagella associated protein 410 | Often (30–79%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Often (30–79%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Often (30–79%) | In 1 condition |
| DAOD-amino acid oxidase | Often (30–79%) | In 1 condition |
| DCTN1dynactin subunit 1 | Often (30–79%) | In 1 condition |
| ERBB4erb-b2 receptor tyrosine kinase 4 | Often (30–79%) | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Often (30–79%) | In 1 condition |
| FUSFUS RNA binding protein | Often (30–79%) | In 1 condition |
| GLE1GLE1 RNA export mediator | Often (30–79%) | In 1 condition |
| GLT8D1glycosyltransferase 8 domain containing 1 | Often (30–79%) | In 1 condition |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Often (30–79%) | In 1 condition |
| LRP12LDL receptor related protein 12 | Often (30–79%) | In 1 condition |
| MATR3matrin 3 | Often (30–79%) | In 1 condition |
| NEFHneurofilament heavy chain | Often (30–79%) | In 1 condition |
| NEK1NIMA related kinase 1 | Often (30–79%) | In 1 condition |
| OPTNoptineurin | Often (30–79%) | In 1 condition |
| PDCD10programmed cell death 10 | Often (30–79%) | In 1 condition |
| PFN1profilin 1 | Often (30–79%) | In 1 condition |
| PRPHperipherin | Often (30–79%) | In 1 condition |
| SLC2A1solute carrier family 2 member 1 | Often (30–79%) | In 2 conditions |
| SOD1superoxide dismutase 1 | Often (30–79%) | In 1 condition |
| SQSTM1sequestosome 1 | Often (30–79%) | In 1 condition |
| TAF15TATA-box binding protein associated factor 15 | Often (30–79%) | In 1 condition |
| TARDBPTAR DNA binding protein | Often (30–79%) | In 1 condition |
| TBK1TANK binding kinase 1 | Often (30–79%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Often (30–79%) | In 1 condition |
| UBQLN2ubiquilin 2 | Often (30–79%) | In 2 conditions |
| UNC13Aunc-13 homolog A | Often (30–79%) | In 1 condition |
| VAPBVAMP associated protein B and C | Often (30–79%) | In 1 condition |
Show 21 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| VCPvalosin containing protein | Often (30–79%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Sometimes (5–29%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| BCHEbutyrylcholinesterase | Rarely (1–4%) | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Rarely (1–4%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Rarely (1–4%) | In 2 conditions |
| ALADaminolevulinate dehydratase | Not recorded | In 1 condition |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Not recorded | In 1 condition |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Not recorded | In 1 condition |
| CD59CD59 molecule (CD59 blood group) | Not recorded | In 1 condition |
| CNTNAP1contactin associated protein 1 | Not recorded | In 1 condition |
| EEF2eukaryotic translation elongation factor 2 | Not recorded | In 1 condition |
| GM2Aganglioside GM2 activator | Not recorded | In 1 condition |
| HK1hexokinase 1 | Not recorded | In 1 condition |
| HMBShydroxymethylbilane synthase | Not recorded | In 1 condition |
| HSPB1heat shock protein family B (small) member 1 | Not recorded | In 1 condition |
| HSPB8heat shock protein family B (small) member 8 | Not recorded | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Not recorded | In 1 condition |
| PPOXprotoporphyrinogen oxidase | Not recorded | In 1 condition |
| SLC25A19solute carrier family 25 member 19 | Not recorded | In 1 condition |
| TRPM7transient receptor potential cation channel subfamily M member 7 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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