Trait
Bone pain
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone.
Summary
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test90 genes linked to Bone pain
Changes in these genes cause rare conditions in which Bone pain is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CYP27B1cytochrome P450 family 27 subfamily B member 1 | Always | In 2 conditions |
| GNASGNAS complex locus | Always | In 4 conditions |
| IL1R1interleukin 1 receptor type 1 | Always | In 1 condition |
| LPIN2lipin 2 | Always | In 2 conditions |
| PSAPprosaposin | Always | In 1 condition |
| SLC34A1solute carrier family 34 member 1 | Always | In 3 conditions |
| ATP7BATPase copper transporting beta | Very often (80–99%) | In 1 condition |
| CLCN7Cl-/H+ antiporter 7 | Very often (80–99%) | In 2 conditions |
| CYP19A1cytochrome P450 family 19 subfamily A member 1 | Very often (80–99%) | In 1 condition |
| CYP2R1cytochrome P450 family 2 subfamily R member 1 | Very often (80–99%) | In 2 conditions |
| DKK1dickkopf Wnt signaling pathway inhibitor 1 | Very often (80–99%) | In 1 condition |
| DMP1dentin matrix acidic phosphoprotein 1 | Very often (80–99%) | In 1 condition |
| ELANEelastase, neutrophil expressed | Very often (80–99%) | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Very often (80–99%) | In 1 condition |
| EXT1exostosin glycosyltransferase 1 | Very often (80–99%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Very often (80–99%) | In 3 conditions |
| HPGD15-hydroxyprostaglandin dehydrogenase | Very often (80–99%) | In 2 conditions |
| MAP2K1mitogen-activated protein kinase kinase 1 | Very often (80–99%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Very often (80–99%) | In 1 condition |
| OSTM1osteoclastogenesis associated transmembrane protein 1 | Very often (80–99%) | In 1 condition |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Very often (80–99%) | In 1 condition |
| RAD21RAD21 cohesin complex component | Very often (80–99%) | In 1 condition |
| SCARB2scavenger receptor class B member 2 | Very often (80–99%) | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Very often (80–99%) | In 1 condition |
| SNX10sorting nexin 10 | Very often (80–99%) | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Very often (80–99%) | In 1 condition |
| TEKTEK receptor tyrosine kinase | Very often (80–99%) | In 1 condition |
| TGFB1transforming growth factor beta 1 | Very often (80–99%) | In 1 condition |
| TNFSF11TNF superfamily member 11 | Very often (80–99%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Very often (80–99%) | In 1 condition |
| TRPS1transcriptional repressor GATA binding 1 | Very often (80–99%) | In 1 condition |
| TYROBPtransmembrane immune signaling adaptor TYROBP | Very often (80–99%) | In 1 condition |
| VCPvalosin containing protein | Very often (80–99%) | In 1 condition |
| VDRvitamin D receptor | Very often (80–99%) | In 2 conditions |
| WNT1Wnt family member 1 | Very often (80–99%) | In 1 condition |
| WNT3AWnt family member 3A | Very often (80–99%) | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Often (30–79%) | In 2 conditions |
| CBLCbl proto-oncogene | Often (30–79%) | In 1 condition |
| CCND1cyclin D1 | Often (30–79%) | In 1 condition |
| EHHADHenoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase | Often (30–79%) | In 1 condition |
Show 50 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| FGF23fibroblast growth factor 23 | Often (30–79%) | In 2 conditions |
| GATMglycine amidinotransferase | Often (30–79%) | In 1 condition |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Often (30–79%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Often (30–79%) | In 2 conditions |
| IDH2isocitrate dehydrogenase (NADP(+)) 2 | Often (30–79%) | In 2 conditions |
| NDUFAF6NADH:ubiquinone oxidoreductase complex assembly factor 6 | Often (30–79%) | In 1 condition |
| NOTCH2notch receptor 2 | Often (30–79%) | In 1 condition |
| PFN1profilin 1 | Often (30–79%) | In 1 condition |
| PHEXphosphate regulating endopeptidase X-linked | Often (30–79%) | In 2 conditions |
| PTH1Rparathyroid hormone 1 receptor | Often (30–79%) | In 1 condition |
| RUNX1RUNX family transcription factor 1 | Often (30–79%) | In 1 condition |
| SLC34A3solute carrier family 34 member 3 | Often (30–79%) | In 2 conditions |
| SRSF2serine and arginine rich splicing factor 2 | Often (30–79%) | In 2 conditions |
| TET2tet methylcytosine dioxygenase 2 | Often (30–79%) | In 2 conditions |
| ALKALK receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 1 condition |
| CDC73cell division cycle 73 | Sometimes (5–29%) | In 2 conditions |
| FIP1L1factor interacting with PAPOLA and CPSF1 | Sometimes (5–29%) | In 1 condition |
| FOXE1forkhead box E1 | Sometimes (5–29%) | In 1 condition |
| HABP2hyaluronan binding protein 2 | Sometimes (5–29%) | In 1 condition |
| HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | Sometimes (5–29%) | In 1 condition |
| IRF2BP2interferon regulatory factor 2 binding protein 2 | Sometimes (5–29%) | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| LEMD3LEM domain containing 3 | Sometimes (5–29%) | In 1 condition |
| LIN28Blin-28 RNA binding posttranscriptional regulator B | Sometimes (5–29%) | In 1 condition |
| LMO1LIM domain only 1 | Sometimes (5–29%) | In 1 condition |
| MINPP1multiple inositol-polyphosphate phosphatase 1 | Sometimes (5–29%) | In 1 condition |
| MYCNMYCN proto-oncogene, bHLH transcription factor | Sometimes (5–29%) | In 1 condition |
| NABP1nucleic acid binding protein 1 | Sometimes (5–29%) | In 1 condition |
| NPM1nucleophosmin 1 | Sometimes (5–29%) | In 1 condition |
| NUMA1nuclear mitotic apparatus protein 1 | Sometimes (5–29%) | In 1 condition |
| PHOX2Bpaired like homeobox 2B | Sometimes (5–29%) | In 1 condition |
| PMLPML nuclear body scaffold | Sometimes (5–29%) | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Sometimes (5–29%) | In 1 condition |
| PSMB8proteasome 20S subunit beta 8 | Sometimes (5–29%) | In 1 condition |
| RARAretinoic acid receptor alpha | Sometimes (5–29%) | In 1 condition |
| SERPINF2serpin family F member 2 | Sometimes (5–29%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Sometimes (5–29%) | In 1 condition |
| STAT5Bsignal transducer and activator of transcription 5B | Sometimes (5–29%) | In 1 condition |
| TBL1XR1TBL1X/Y related 1 | Sometimes (5–29%) | In 1 condition |
| ZBTB16zinc finger and BTB domain containing 16 | Sometimes (5–29%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Rarely (1–4%) | In 1 condition |
| AGXTalanine--glyoxylate aminotransferase | Not recorded | In 1 condition |
| AP2S1adaptor related protein complex 2 subunit sigma 1 | Not recorded | In 1 condition |
| CLCN5Cl-/H+ antiporter 5 | Not recorded | In 2 conditions |
| KIF1Bkinesin family member 1B | Not recorded | In 1 condition |
| SQSTM1sequestosome 1 | Not recorded | In 1 condition |
| TNFRSF11ATNF receptor superfamily member 11a | Not recorded | In 2 conditions |
| ZNF687zinc finger protein 687 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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