Trait
Disinhibition
Reduced ability to control, or a failure to resist a temptation, urge, or impulse. Examples include disregard for social conventions, general impulsivity, and poor risk assessment.
Summary
- Also called
- Impulse control disorders, Lack of self-control
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test26 genes linked to Disinhibition
Changes in these genes cause rare conditions in which Disinhibition is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CHMP2Bcharged multivesicular body protein 2B | Very often (80–99%) | In 2 conditions |
| GRNgranulin precursor | Very often (80–99%) | In 2 conditions |
| MAPTmicrotubule associated protein tau | Very often (80–99%) | In 3 conditions |
| PSEN1presenilin 1 | Very often (80–99%) | In 4 conditions |
| SQSTM1sequestosome 1 | Very often (80–99%) | In 3 conditions |
| TMEM106Btransmembrane protein 106B | Very often (80–99%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Very often (80–99%) | In 5 conditions |
| TYROBPtransmembrane immune signaling adaptor TYROBP | Very often (80–99%) | In 2 conditions |
| VCPvalosin containing protein | Very often (80–99%) | In 2 conditions |
| APPamyloid beta precursor protein | Often (30–79%) | In 1 condition |
| DCTN1dynactin subunit 1 | Often (30–79%) | In 1 condition |
| HTThuntingtin | Often (30–79%) | In 1 condition |
| PSEN2presenilin 2 | Often (30–79%) | In 1 condition |
| SLC2A3solute carrier family 2 member 3 | Often (30–79%) | In 1 condition |
| SORL1sortilin related receptor 1 | Often (30–79%) | In 1 condition |
| TOMM40translocase of outer mitochondrial membrane 40 | Often (30–79%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Sometimes (5–29%) | In 1 condition |
| FUSFUS RNA binding protein | Sometimes (5–29%) | In 1 condition |
| PTPAprotein phosphatase 2 phosphatase activator | Sometimes (5–29%) | In 1 condition |
| TARDBPTAR DNA binding protein | Sometimes (5–29%) | In 2 conditions |
| TBK1TANK binding kinase 1 | Sometimes (5–29%) | In 2 conditions |
| ABCA7ATP binding cassette subfamily A member 7 | Not recorded | In 1 condition |
| FMR1fragile X messenger ribonucleoprotein 1 | Not recorded | In 1 condition |
| FTLferritin light chain | Not recorded | In 1 condition |
| SPASTspastin | Not recorded | In 1 condition |
| VPS13Avacuolar protein sorting 13 homolog A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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