Trait
Poor speech
Summary
- Also called
- Difficulty speaking, Problems speaking
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test198 genes linked to Poor speech
Changes in these genes cause rare conditions in which Poor speech is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADKadenosine kinase | Always | In 1 condition |
| AHDC1AT-hook DNA binding motif containing 1 | Always | In 1 condition |
| APC2APC regulator of Wnt signaling pathway 2 | Always | In 1 condition |
| CAMK2Gcalcium/calmodulin dependent protein kinase II gamma | Always | In 1 condition |
| CCDC22CCC complex scaffolding subunit CCDC22 | Always | In 1 condition |
| HEPHL1hephaestin like 1 | Always | In 1 condition |
| HS6ST2heparan sulfate 6-O-sulfotransferase 2 | Always | In 1 condition |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Always | In 1 condition |
| KMT2Blysine methyltransferase 2B | Always | In 1 condition |
| MRPS2mitochondrial ribosomal protein S2 | Always | In 1 condition |
| PIGCphosphatidylinositol glycan anchor biosynthesis class C | Always | In 1 condition |
| SASS6SAS-6 centriolar assembly protein | Always | In 1 condition |
| SGSM3small G protein signaling modulator 3 | Always | In 1 condition |
| SNAP25synaptosome associated protein 25 | Always | In 1 condition |
| AP1S2adaptor related protein complex 1 subunit sigma 2 | Very often (80–99%) | In 1 condition |
| ATP6V0A2ATPase H+ transporting V0 subunit a2 | Very often (80–99%) | In 1 condition |
| ATP6V1AATPase H+ transporting V1 subunit A | Very often (80–99%) | In 1 condition |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Very often (80–99%) | In 1 condition |
| CASZ1castor zinc finger 1 | Very often (80–99%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Very often (80–99%) | In 1 condition |
| CTNNB1catenin beta 1 | Very often (80–99%) | In 1 condition |
| FMN2formin 2 | Very often (80–99%) | In 1 condition |
| GABRDgamma-aminobutyric acid type A receptor subunit delta | Very often (80–99%) | In 1 condition |
| GRNgranulin precursor | Very often (80–99%) | In 1 condition |
| HDAC8histone deacetylase 8 | Very often (80–99%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Very often (80–99%) | In 1 condition |
| KAT6Alysine acetyltransferase 6A | Very often (80–99%) | In 1 condition |
| KCNAB2potassium voltage-gated channel subfamily A regulatory beta subunit 2 | Very often (80–99%) | In 1 condition |
| LAS1LLAS1 like ribosome biogenesis factor | Very often (80–99%) | In 1 condition |
| LUZP1leucine zipper protein 1 | Very often (80–99%) | In 1 condition |
| MAPTmicrotubule associated protein tau | Very often (80–99%) | In 2 conditions |
| MMP23Bmatrix metallopeptidase 23B | Very often (80–99%) | In 1 condition |
| PAK3p21 (RAC1) activated kinase 3 | Very often (80–99%) | In 1 condition |
| PDPNpodoplanin | Very often (80–99%) | In 1 condition |
| PRDM16PR/SET domain 16 | Very often (80–99%) | In 1 condition |
| PRKCZprotein kinase C zeta | Very often (80–99%) | In 1 condition |
| PSEN1presenilin 1 | Very often (80–99%) | In 1 condition |
| REREarginine-glutamic acid dipeptide repeats | Very often (80–99%) | In 1 condition |
| SKISKI proto-oncogene | Very often (80–99%) | In 1 condition |
| SPENspen family transcriptional repressor | Very often (80–99%) | In 1 condition |
Show 158 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SQSTM1sequestosome 1 | Very often (80–99%) | In 1 condition |
| TMEM106Btransmembrane protein 106B | Very often (80–99%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Very often (80–99%) | In 1 condition |
| TRIOtrio Rho guanine nucleotide exchange factor | Very often (80–99%) | In 2 conditions |
| UBE2Aubiquitin conjugating enzyme E2 A | Very often (80–99%) | In 2 conditions |
| UBE4Bubiquitination factor E4B | Very often (80–99%) | In 1 condition |
| VCPvalosin containing protein | Very often (80–99%) | In 1 condition |
| AP4B1adaptor related protein complex 4 subunit beta 1 | Often (30–79%) | In 1 condition |
| AP4E1adaptor related protein complex 4 subunit epsilon 1 | Often (30–79%) | In 1 condition |
| AP4M1adaptor related protein complex 4 subunit mu 1 | Often (30–79%) | In 1 condition |
| AP4S1adaptor related protein complex 4 subunit sigma 1 | Often (30–79%) | In 1 condition |
| ASPAaspartoacylase | Often (30–79%) | In 1 condition |
| ATAD3AATPase family AAA domain containing 3A | Often (30–79%) | In 1 condition |
| ATP1A1ATPase Na+/K+ transporting subunit alpha 1 | Often (30–79%) | In 1 condition |
| BRF1BRF1 general transcription factor IIIB subunit | Often (30–79%) | In 1 condition |
| CDONcell adhesion associated, oncogene regulated | Often (30–79%) | In 4 conditions |
| CNTNAP2contactin associated protein 2 | Often (30–79%) | In 2 conditions |
| COG8component of oligomeric golgi complex 8 | Often (30–79%) | In 1 condition |
| CRIPTOcripto, EGF-CFC family member | Often (30–79%) | In 4 conditions |
| DISP1dispatched RND transporter family member 1 | Often (30–79%) | In 4 conditions |
| DLL1delta like canonical Notch ligand 1 | Often (30–79%) | In 4 conditions |
| DOCK7dedicator of cytokinesis 7 | Often (30–79%) | In 1 condition |
| DYRK1Adual specificity tyrosine phosphorylation regulated kinase 1A | Often (30–79%) | In 1 condition |
| EBF3EBF transcription factor 3 | Often (30–79%) | In 1 condition |
| FDXRferredoxin reductase | Often (30–79%) | In 1 condition |
| FGF8fibroblast growth factor 8 | Often (30–79%) | In 4 conditions |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 2 conditions |
| FOXH1forkhead box H1 | Often (30–79%) | In 4 conditions |
| FOXP2forkhead box P2 | Often (30–79%) | In 1 condition |
| GAMTguanidinoacetate N-methyltransferase | Often (30–79%) | In 1 condition |
| GAS1growth arrest specific 1 | Often (30–79%) | In 4 conditions |
| GATA4GATA binding protein 4 | Often (30–79%) | In 1 condition |
| GATAD2BGATA zinc finger domain containing 2B | Often (30–79%) | In 2 conditions |
| GLI2GLI family zinc finger 2 | Often (30–79%) | In 4 conditions |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Often (30–79%) | In 1 condition |
| HNRNPKheterogeneous nuclear ribonucleoprotein K | Often (30–79%) | In 3 conditions |
| INPP5Einositol polyphosphate-5-phosphatase E | Often (30–79%) | In 1 condition |
| LRPPRCleucine rich pentatricopeptide repeat containing | Often (30–79%) | In 1 condition |
| MAB21L1mab-21 like 1 | Often (30–79%) | In 1 condition |
| MAN1B1mannosidase alpha class 1B member 1 | Often (30–79%) | In 1 condition |
| MED13Lmediator complex subunit 13L | Often (30–79%) | In 2 conditions |
| MED25mediator complex subunit 25 | Often (30–79%) | In 1 condition |
| MID2midline 2 | Often (30–79%) | In 1 condition |
| NGLY1N-glycanase 1 | Often (30–79%) | In 1 condition |
| NODALnodal growth differentiation factor | Often (30–79%) | In 4 conditions |
| OPHN1oligophrenin 1 | Often (30–79%) | In 1 condition |
| PPP1R15Bprotein phosphatase 1 regulatory subunit 15B | Often (30–79%) | In 1 condition |
| PPP2R1Aprotein phosphatase 2 scaffold subunit Aalpha | Often (30–79%) | In 1 condition |
| PPP2R5Dprotein phosphatase 2 regulatory subunit B'delta | Often (30–79%) | In 1 condition |
| PTCH1patched 1 | Often (30–79%) | In 4 conditions |
| PUS3pseudouridine synthase 3 | Often (30–79%) | In 1 condition |
| RAC1Rac family small GTPase 1 | Often (30–79%) | In 1 condition |
| RILPL1Rab interacting lysosomal protein like 1 | Often (30–79%) | In 1 condition |
| RTTNrotatin | Often (30–79%) | In 2 conditions |
| SHHsonic hedgehog signaling molecule | Often (30–79%) | In 4 conditions |
| SIX3SIX homeobox 3 | Often (30–79%) | In 4 conditions |
| SLC19A3solute carrier family 19 member 3 | Often (30–79%) | In 1 condition |
| SLC39A14solute carrier family 39 member 14 | Often (30–79%) | In 1 condition |
| SLC6A17solute carrier family 6 member 17 | Often (30–79%) | In 1 condition |
| STILSTIL centriolar assembly protein | Often (30–79%) | In 4 conditions |
| SYNGAP1synaptic Ras GTPase activating protein 1 | Often (30–79%) | In 1 condition |
| TAF2TATA-box binding protein associated factor 2 | Often (30–79%) | In 1 condition |
| TBCDtubulin folding cofactor D | Often (30–79%) | In 1 condition |
| TELO2telomere maintenance 2 | Often (30–79%) | In 1 condition |
| TGIF1TGFB induced factor homeobox 1 | Often (30–79%) | In 4 conditions |
| TRAPPC10trafficking protein particle complex subunit 10 | Often (30–79%) | In 1 condition |
| TRMT10AtRNA methyltransferase 10A | Often (30–79%) | In 1 condition |
| TRMT5tRNA methyltransferase 5 | Often (30–79%) | In 1 condition |
| TUBB3tubulin beta 3 class III | Often (30–79%) | In 1 condition |
| UBE3Aubiquitin protein ligase E3A | Often (30–79%) | In 3 conditions |
| VPS11VPS11 core subunit of CORVET and HOPS complexes | Often (30–79%) | In 2 conditions |
| WDR45WD repeat domain 45 | Often (30–79%) | In 2 conditions |
| YME1L1YME1 like 1 ATPase | Often (30–79%) | In 1 condition |
| ZIC2Zic family zinc finger 2 | Often (30–79%) | In 4 conditions |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Sometimes (5–29%) | In 1 condition |
| ATP10AATPase phospholipid transporting 10A (putative) | Sometimes (5–29%) | In 1 condition |
| ATP6V1B2ATPase H+ transporting V1 subunit B2 | Sometimes (5–29%) | In 1 condition |
| CDC42cell division cycle 42 | Sometimes (5–29%) | In 1 condition |
| CHSY1chondroitin sulfate synthase 1 | Sometimes (5–29%) | In 1 condition |
| CLIC2CLIC family member 2 | Sometimes (5–29%) | In 1 condition |
| DAG1dystroglycan 1 | Sometimes (5–29%) | In 1 condition |
| DYMdymeclin | Sometimes (5–29%) | In 1 condition |
| FKRPfukutin related protein | Sometimes (5–29%) | In 1 condition |
| FRMD4AFERM domain containing 4A | Sometimes (5–29%) | In 1 condition |
| GMPPBGDP-mannose pyrophosphorylase B | Sometimes (5–29%) | In 1 condition |
| IFNGinterferon gamma | Sometimes (5–29%) | In 1 condition |
| KIF15kinesin family member 15 | Sometimes (5–29%) | In 1 condition |
| LARGE1LARGE xylosyl- and glucuronyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| MID1midline 1 | Sometimes (5–29%) | In 1 condition |
| MTO1mitochondrial tRNA translation optimization 1 | Sometimes (5–29%) | In 2 conditions |
| NAA20N-alpha-acetyltransferase 20, NatB catalytic subunit | Sometimes (5–29%) | In 1 condition |
| NAGSN-acetylglutamate synthase | Sometimes (5–29%) | In 1 condition |
| NONOnon-POU domain containing octamer binding | Sometimes (5–29%) | In 1 condition |
| OCA2OCA2 melanosomal transmembrane protein | Sometimes (5–29%) | In 1 condition |
| ODC1ornithine decarboxylase 1 | Sometimes (5–29%) | In 1 condition |
| PLCH1phospholipase C eta 1 | Sometimes (5–29%) | In 1 condition |
| POMT1protein O-mannosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| POMT2protein O-mannosyltransferase 2 | Sometimes (5–29%) | In 1 condition |
| PYCR2pyrroline-5-carboxylate reductase 2 | Sometimes (5–29%) | In 1 condition |
| SARDHsarcosine dehydrogenase | Sometimes (5–29%) | In 1 condition |
| SATB2SATB homeobox 2 | Sometimes (5–29%) | In 1 condition |
| SLC39A8solute carrier family 39 member 8 | Sometimes (5–29%) | In 1 condition |
| SMC1Astructural maintenance of chromosomes 1A | Sometimes (5–29%) | In 2 conditions |
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Sometimes (5–29%) | In 1 condition |
| STAG2STAG2 cohesin complex component | Sometimes (5–29%) | In 2 conditions |
| SYT1synaptotagmin 1 | Sometimes (5–29%) | In 1 condition |
| TSC1TSC complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| TSC2TSC complex subunit 2 | Sometimes (5–29%) | In 1 condition |
| ZNF148zinc finger protein 148 | Sometimes (5–29%) | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Rarely (1–4%) | In 2 conditions |
| ADPRSADP-ribosylserine hydrolase | Not recorded | In 1 condition |
| ALG9ALG9 alpha-1,2-mannosyltransferase | Not recorded | In 1 condition |
| CADcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | Not recorded | In 1 condition |
| CHKBcholine kinase beta | Not recorded | In 1 condition |
| CHMP1Acharged multivesicular body protein 1A | Not recorded | In 1 condition |
| CICcapicua transcriptional repressor | Not recorded | In 1 condition |
| CSF1Rcolony stimulating factor 1 receptor | Not recorded | In 1 condition |
| DIAPH1diaphanous related formin 1 | Not recorded | In 1 condition |
| DLATdihydrolipoamide S-acetyltransferase | Not recorded | In 1 condition |
| EIF2S3eukaryotic translation initiation factor 2 subunit gamma | Not recorded | In 1 condition |
| EXT2exostosin glycosyltransferase 2 | Not recorded | In 1 condition |
| FBXL3F-box and leucine rich repeat protein 3 | Not recorded | In 1 condition |
| FGF12fibroblast growth factor 12 | Not recorded | In 1 condition |
| FOXRED1FAD dependent oxidoreductase domain containing 1 | Not recorded | In 1 condition |
| GJC2gap junction protein gamma 2 | Not recorded | In 1 condition |
| GPR88G protein-coupled receptor 88 | Not recorded | In 1 condition |
| GUSBglucuronidase beta | Not recorded | In 1 condition |
| IQSEC2IQ motif and Sec7 domain ArfGEF 2 | Not recorded | In 1 condition |
| KANSL1KAT8 regulatory NSL complex subunit 1 | Not recorded | In 1 condition |
| KIF14kinesin family member 14 | Not recorded | In 1 condition |
| NALCNsodium leak channel, non-selective | Not recorded | In 1 condition |
| NDST1N-deacetylase and N-sulfotransferase 1 | Not recorded | In 1 condition |
| NDUFA13NADH:ubiquinone oxidoreductase subunit A13 | Not recorded | In 1 condition |
| NDUFA6NADH:ubiquinone oxidoreductase subunit A6 | Not recorded | In 1 condition |
| NDUFS1NADH:ubiquinone oxidoreductase core subunit S1 | Not recorded | In 1 condition |
| NUBPLNUBP iron-sulfur cluster assembly factor, mitochondrial | Not recorded | In 1 condition |
| PAK1p21 (RAC1) activated kinase 1 | Not recorded | In 1 condition |
| PIGHphosphatidylinositol glycan anchor biosynthesis class H | Not recorded | In 1 condition |
| PLPBPpyridoxal phosphate binding protein | Not recorded | In 1 condition |
| POMKprotein O-mannose kinase | Not recorded | In 1 condition |
| RAB39BRAB39B, member RAS oncogene family | Not recorded | In 1 condition |
| RLIMring finger protein, LIM domain interacting | Not recorded | In 1 condition |
| RNASET2ribonuclease T2 | Not recorded | In 1 condition |
| SETSET nuclear proto-oncogene | Not recorded | In 1 condition |
| SLC35A1solute carrier family 35 member A1 | Not recorded | In 1 condition |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Not recorded | In 1 condition |
| SMC3structural maintenance of chromosomes 3 | Not recorded | In 1 condition |
| SOBPsine oculis binding protein homolog | Not recorded | In 1 condition |
| TAF6TATA-box binding protein associated factor 6 | Not recorded | In 1 condition |
| TBCKTBC1 domain containing kinase | Not recorded | In 1 condition |
| TRAPPC11trafficking protein particle complex subunit 11 | Not recorded | In 1 condition |
| TRRAPtransformation/transcription domain associated protein | Not recorded | In 1 condition |
| TUBB4Atubulin beta 4A class IVa | Not recorded | In 1 condition |
| UNC80unc-80 subunit of NALCN channel complex | Not recorded | In 1 condition |
| UQCC2ubiquinol-cytochrome c reductase complex assembly factor 2 | Not recorded | In 1 condition |
| VLDLRvery low density lipoprotein receptor | Not recorded | In 1 condition |
| WDR73WD repeat domain 73 | Not recorded | In 1 condition |
| WIPI2WD repeat domain, phosphoinositide interacting 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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