Trait
Abulia
Abulia is characterized by difficulty in initiating and sustaining spontaneous movements; the person often appears frozen but will move hesitantly on request. There are frequently substantial reductions in emotional responsiveness, spontaneous speech, and social interaction. The individual appears to be content to remain still and inactive with minimal movement, but moves or reacts hesitantly in response to interactions.
Summary
- Also called
- Aboulia
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test10 genes linked to Abulia
Changes in these genes cause rare conditions in which Abulia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| NOTCH3notch receptor 3 | Always | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Often (30–79%) | In 2 conditions |
| GRNgranulin precursor | Often (30–79%) | In 2 conditions |
| MAPTmicrotubule associated protein tau | Often (30–79%) | In 2 conditions |
| PSEN1presenilin 1 | Often (30–79%) | In 2 conditions |
| TMEM106Btransmembrane protein 106B | Often (30–79%) | In 2 conditions |
| TREM2triggering receptor expressed on myeloid cells 2 | Often (30–79%) | In 2 conditions |
| HTRA1HtrA serine peptidase 1 | Sometimes (5–29%) | In 1 condition |
| SQSTM1sequestosome 1 | Sometimes (5–29%) | In 1 condition |
| VCPvalosin containing protein | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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