Trait
Muscle twitch
Clinical name: Fasciculations
Fasciculations are observed as small, local, involuntary muscle contractions (twitching) visible under the skin. Fasciculations result from increased irritability of an axon (which in turn is often a manifestation of disease of a motor neuron). This leads to sporadic discharges of all the muscle fibers controlled by the axon in isolation from other motor units.
Summary
- Also called
- Fasciculation, Muscle fasciculation
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test91 genes linked to Muscle twitch
Changes in these genes cause rare conditions in which Muscle twitch is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DARS2aspartyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| RAB7ARAB7A, member RAS oncogene family | Always | In 1 condition |
| VAPBVAMP associated protein B and C | Always | In 4 conditions |
| VCPvalosin containing protein | Always | In 6 conditions |
| VRK1VRK serine/threonine kinase 1 | Always | In 1 condition |
| ATAD1ATPase family AAA domain containing 1 | Very often (80–99%) | In 1 condition |
| GLRA1glycine receptor alpha 1 | Very often (80–99%) | In 1 condition |
| GLRBglycine receptor beta | Very often (80–99%) | In 1 condition |
| GPHNgephyrin | Very often (80–99%) | In 1 condition |
| KIF1Ckinesin family member 1C | Very often (80–99%) | In 2 conditions |
| SLC6A5solute carrier family 6 member 5 | Very often (80–99%) | In 1 condition |
| ANGangiogenin | Often (30–79%) | In 1 condition |
| ANO10anoctamin 10 | Often (30–79%) | In 2 conditions |
| ANXA11annexin A11 | Often (30–79%) | In 2 conditions |
| ATXN2ataxin 2 | Often (30–79%) | In 3 conditions |
| CCNFcyclin F | Often (30–79%) | In 2 conditions |
| CFAP410cilia and flagella associated protein 410 | Often (30–79%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Often (30–79%) | In 4 conditions |
| CHMP2Bcharged multivesicular body protein 2B | Often (30–79%) | In 2 conditions |
| COQ7coenzyme Q7, hydroxylase | Often (30–79%) | In 1 condition |
| DAOD-amino acid oxidase | Often (30–79%) | In 1 condition |
| DCTN1dynactin subunit 1 | Often (30–79%) | In 2 conditions |
| ERBB4erb-b2 receptor tyrosine kinase 4 | Often (30–79%) | In 1 condition |
| EXOSC9exosome component 9 | Often (30–79%) | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Often (30–79%) | In 1 condition |
| FUSFUS RNA binding protein | Often (30–79%) | In 3 conditions |
| GLE1GLE1 RNA export mediator | Often (30–79%) | In 1 condition |
| GLT8D1glycosyltransferase 8 domain containing 1 | Often (30–79%) | In 1 condition |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Often (30–79%) | In 2 conditions |
| LRP12LDL receptor related protein 12 | Often (30–79%) | In 2 conditions |
| MATR3matrin 3 | Often (30–79%) | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Often (30–79%) | In 1 condition |
| NEFHneurofilament heavy chain | Often (30–79%) | In 2 conditions |
| NEK1NIMA related kinase 1 | Often (30–79%) | In 1 condition |
| NOP56NOP56 ribonucleoprotein | Often (30–79%) | In 2 conditions |
| OPTNoptineurin | Often (30–79%) | In 2 conditions |
| PFN1profilin 1 | Often (30–79%) | In 2 conditions |
| PNPLA2patatin like domain 2, triacylglycerol lipase | Often (30–79%) | In 2 conditions |
| PRPHperipherin | Often (30–79%) | In 2 conditions |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Often (30–79%) | In 1 condition |
Show 51 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SCO2synthesis of cytochrome C oxidase 2 | Often (30–79%) | In 1 condition |
| SOD1superoxide dismutase 1 | Often (30–79%) | In 3 conditions |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Often (30–79%) | In 1 condition |
| SQSTM1sequestosome 1 | Often (30–79%) | In 4 conditions |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Often (30–79%) | In 1 condition |
| TAF15TATA-box binding protein associated factor 15 | Often (30–79%) | In 1 condition |
| TARDBPTAR DNA binding protein | Often (30–79%) | In 2 conditions |
| TBK1TANK binding kinase 1 | Often (30–79%) | In 3 conditions |
| TOE1target of EGR1, exonuclease | Often (30–79%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Often (30–79%) | In 2 conditions |
| UBQLN2ubiquilin 2 | Often (30–79%) | In 1 condition |
| UCHL1ubiquitin C-terminal hydrolase L1 | Often (30–79%) | In 1 condition |
| UNC13Aunc-13 homolog A | Often (30–79%) | In 1 condition |
| VPS13Dvacuolar protein sorting 13 homolog D | Often (30–79%) | In 2 conditions |
| VPS41VPS41 subunit of HOPS complex | Often (30–79%) | In 1 condition |
| ATXN1ataxin 1 | Sometimes (5–29%) | In 2 conditions |
| ATXN3ataxin 3 | Sometimes (5–29%) | In 1 condition |
| BICD2BICD cargo adaptor 2 | Sometimes (5–29%) | In 1 condition |
| CEP126centrosomal protein 126 | Sometimes (5–29%) | In 1 condition |
| COL25A1collagen type XXV alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| CPLANE1ciliogenesis and planar polarity effector complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| ELOVL4ELOVL fatty acid elongase 4 | Sometimes (5–29%) | In 1 condition |
| ERGIC1endoplasmic reticulum-golgi intermediate compartment 1 | Sometimes (5–29%) | In 1 condition |
| GRNgranulin precursor | Sometimes (5–29%) | In 1 condition |
| HEXBhexosaminidase subunit beta | Sometimes (5–29%) | In 3 conditions |
| HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B1 | Sometimes (5–29%) | In 1 condition |
| HSPB1heat shock protein family B (small) member 1 | Sometimes (5–29%) | In 1 condition |
| JAG1jagged canonical Notch ligand 1 | Sometimes (5–29%) | In 1 condition |
| MAPTmicrotubule associated protein tau | Sometimes (5–29%) | In 1 condition |
| MED11mediator complex subunit 11 | Sometimes (5–29%) | In 1 condition |
| MORC2MORC family CW-type zinc finger 2 | Sometimes (5–29%) | In 2 conditions |
| NEFLneurofilament light chain | Sometimes (5–29%) | In 1 condition |
| PSEN1presenilin 1 | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 1 condition |
| SCYL2SCY1 like pseudokinase 2 | Sometimes (5–29%) | In 1 condition |
| TBCDtubulin folding cofactor D | Sometimes (5–29%) | In 1 condition |
| TMEM106Btransmembrane protein 106B | Sometimes (5–29%) | In 1 condition |
| COQ6coenzyme Q6, monooxygenase | Rarely (1–4%) | In 1 condition |
| LZTR1leucine zipper like post translational regulator 1 | Rarely (1–4%) | In 1 condition |
| NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor | Rarely (1–4%) | In 1 condition |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Rarely (1–4%) | In 1 condition |
| ARandrogen receptor | Not recorded | In 1 condition |
| DMDdystrophin | Not recorded | In 1 condition |
| EEF2eukaryotic translation elongation factor 2 | Not recorded | In 1 condition |
| FBXO38F-box protein 38 | Not recorded | In 1 condition |
| GLAgalactosidase alpha | Not recorded | In 1 condition |
| HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | Not recorded | In 1 condition |
| HINT1histidine triad nucleotide binding protein 1 | Not recorded | In 1 condition |
| LRSAM1leucine rich repeat and sterile alpha motif containing 1 | Not recorded | In 1 condition |
| PSAPprosaposin | Not recorded | In 1 condition |
| TFGtrafficking from ER to golgi regulator | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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