Trait
Nerve damage causing decreased feeling and movement
Clinical name: Sensorimotor neuropathy
Summary
- Also called
- Mixed polyneuropathy, Sensorimotor peripheral neuropathy
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Nerve damage causing decreased feeling and movement, and the rest of your genome, with one test.
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Get my Genome Test107 genes linked to Nerve damage causing decreased feeling and movement
Changes in these genes cause rare conditions in which Nerve damage causing decreased feeling and movement is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AFG3L2AFG3 like matrix AAA peptidase subunit 2 | Always | In 2 conditions |
| ARHGAP19Rho GTPase activating protein 19 | Always | In 1 condition |
| CLCF1cardiotrophin like cytokine factor 1 | Always | In 1 condition |
| COA3cytochrome c oxidase assembly factor 3 | Always | In 1 condition |
| GET4guided entry of tail-anchored proteins factor 4 | Always | In 1 condition |
| HMBShydroxymethylbilane synthase | Always | In 2 conditions |
| HSD17B4hydroxysteroid 17-beta dehydrogenase 4 | Always | In 1 condition |
| LAMA2laminin subunit alpha 2 | Always | In 2 conditions |
| LITAFlipopolysaccharide induced TNF factor | Always | In 1 condition |
| MCM3APminichromosome maintenance complex component 3 associated protein | Always | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Always | In 2 conditions |
| RAB7ARAB7A, member RAS oncogene family | Always | In 1 condition |
| RCC1regulator of chromosome condensation 1 | Always | In 1 condition |
| SPTLC2serine palmitoyltransferase long chain base subunit 2 | Always | In 1 condition |
| TYMPthymidine phosphorylase | Always | In 2 conditions |
| XRCC1X-ray repair cross complementing 1 | Always | In 1 condition |
| ADA2adenosine deaminase 2 | Very often (80–99%) | In 1 condition |
| AIFM1apoptosis inducing factor mitochondria associated 1 | Very often (80–99%) | In 1 condition |
| DHHdesert hedgehog signaling molecule | Very often (80–99%) | In 1 condition |
| GALCgalactosylceramidase | Very often (80–99%) | In 4 conditions |
| GDAP1ganglioside induced differentiation associated protein 1 | Very often (80–99%) | In 1 condition |
| LIG3DNA ligase 3 | Very often (80–99%) | In 1 condition |
| MMEmembrane metalloendopeptidase | Very often (80–99%) | In 3 conditions |
| NEFLneurofilament light chain | Very often (80–99%) | In 3 conditions |
| NGLY1N-glycanase 1 | Very often (80–99%) | In 1 condition |
| PDK3pyruvate dehydrogenase kinase 3 | Very often (80–99%) | In 1 condition |
| PIK3R5phosphoinositide-3-kinase regulatory subunit 5 | Very often (80–99%) | In 1 condition |
| PSAPprosaposin | Very often (80–99%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Very often (80–99%) | In 2 conditions |
| SETXsenataxin | Very often (80–99%) | In 1 condition |
| SH3TC2SH3 domain and tetratricopeptide repeats 2 | Very often (80–99%) | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Very often (80–99%) | In 1 condition |
| TFGtrafficking from ER to golgi regulator | Very often (80–99%) | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Often (30–79%) | In 1 condition |
| AMACRalpha-methylacyl-CoA racemase | Often (30–79%) | In 2 conditions |
| B4GALNT1beta-1,4-N-acetyl-galactosaminyltransferase 1 | Often (30–79%) | In 1 condition |
| CLP1cleavage factor polyribonucleotide kinase subunit 1 | Often (30–79%) | In 1 condition |
| COA8cytochrome c oxidase assembly factor 8 | Often (30–79%) | In 1 condition |
| DNAJC3DnaJ heat shock protein family (Hsp40) member C3 | Often (30–79%) | In 1 condition |
| DNM1Ldynamin 1L | Often (30–79%) | In 1 condition |
Show 67 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| EMILIN1elastin microfibril interfacer 1 | Often (30–79%) | In 1 condition |
| GBA2glucosylceramidase beta 2 | Often (30–79%) | In 1 condition |
| GJB1gap junction protein beta 1 | Often (30–79%) | In 1 condition |
| IFRD1interferon related developmental regulator 1 | Often (30–79%) | In 1 condition |
| KIF1Akinesin family member 1A | Often (30–79%) | In 2 conditions |
| MPZmyelin protein zero | Often (30–79%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Often (30–79%) | In 1 condition |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Often (30–79%) | In 2 conditions |
| MT-ND2mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 | Often (30–79%) | In 1 condition |
| MT-ND3mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 | Often (30–79%) | In 1 condition |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Often (30–79%) | In 2 conditions |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Often (30–79%) | In 2 conditions |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Often (30–79%) | In 2 conditions |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Often (30–79%) | In 1 condition |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Often (30–79%) | In 2 conditions |
| MT-TVmitochondrially encoded tRNA-Val (GUN) | Often (30–79%) | In 1 condition |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Often (30–79%) | In 2 conditions |
| OPA1OPA1 mitochondrial dynamin like GTPase | Often (30–79%) | In 2 conditions |
| PEX6peroxisomal biogenesis factor 6 | Often (30–79%) | In 1 condition |
| PLA2G6phospholipase A2 group VI | Often (30–79%) | In 1 condition |
| PMP22peripheral myelin protein 22 | Often (30–79%) | In 2 conditions |
| PPIBpeptidylprolyl isomerase B | Often (30–79%) | In 1 condition |
| RFC1replication factor C subunit 1 | Often (30–79%) | In 1 condition |
| SACSsacsin molecular chaperone | Often (30–79%) | In 1 condition |
| SCO2synthesis of cytochrome C oxidase 2 | Often (30–79%) | In 1 condition |
| SLC25A46solute carrier family 25 member 46 | Often (30–79%) | In 1 condition |
| TDP1tyrosyl-DNA phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| UCHL1ubiquitin C-terminal hydrolase L1 | Often (30–79%) | In 1 condition |
| VCPvalosin containing protein | Often (30–79%) | In 1 condition |
| VPS13Dvacuolar protein sorting 13 homolog D | Often (30–79%) | In 1 condition |
| VPS41VPS41 subunit of HOPS complex | Often (30–79%) | In 1 condition |
| VRK1VRK serine/threonine kinase 1 | Often (30–79%) | In 1 condition |
| AHCYadenosylhomocysteinase | Sometimes (5–29%) | In 1 condition |
| B2Mbeta-2-microglobulin | Sometimes (5–29%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Sometimes (5–29%) | In 1 condition |
| KIF5Akinesin family member 5A | Sometimes (5–29%) | In 1 condition |
| MRE11MRE11 double strand break repair nuclease | Sometimes (5–29%) | In 1 condition |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Sometimes (5–29%) | In 1 condition |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Sometimes (5–29%) | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Sometimes (5–29%) | In 1 condition |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Sometimes (5–29%) | In 1 condition |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Sometimes (5–29%) | In 1 condition |
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Sometimes (5–29%) | In 1 condition |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Sometimes (5–29%) | In 1 condition |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Sometimes (5–29%) | In 1 condition |
| PNKPpolynucleotide kinase 3'-phosphatase | Sometimes (5–29%) | In 1 condition |
| PPP2R2Bprotein phosphatase 2 regulatory subunit Bbeta | Sometimes (5–29%) | In 2 conditions |
| RNASEH1ribonuclease H1 | Sometimes (5–29%) | In 1 condition |
| RRM1ribonucleotide reductase catalytic subunit M1 | Sometimes (5–29%) | In 1 condition |
| SCARB2scavenger receptor class B member 2 | Sometimes (5–29%) | In 1 condition |
| SLC30A10solute carrier family 30 member 10 | Sometimes (5–29%) | In 1 condition |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Rarely (1–4%) | In 1 condition |
| HADHBhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | Rarely (1–4%) | In 1 condition |
| ABHD12abhydrolase domain containing 12, lysophospholipase | Not recorded | In 1 condition |
| ATP1A1ATPase Na+/K+ transporting subunit alpha 1 | Not recorded | In 1 condition |
| FDX2ferredoxin 2 | Not recorded | In 1 condition |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Not recorded | In 1 condition |
| IGHMBP2immunoglobulin mu DNA binding protein 2 | Not recorded | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Not recorded | In 1 condition |
| NEFHneurofilament heavy chain | Not recorded | In 1 condition |
| PDYNprodynorphin | Not recorded | In 1 condition |
| PEX7peroxisomal biogenesis factor 7 | Not recorded | In 1 condition |
| PHYHphytanoyl-CoA 2-hydroxylase | Not recorded | In 1 condition |
| PIGBphosphatidylinositol glycan anchor biosynthesis class B | Not recorded | In 1 condition |
| RPIAribose 5-phosphate isomerase A | Not recorded | In 1 condition |
| SCYL1SCY1 like pseudokinase 1 | Not recorded | In 1 condition |
| SLC52A2solute carrier family 52 member 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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