Trait

Facial diplegia

Facial diplegia refers to bilateral facial palsy (bilateral facial palsy is much rarer than unilateral facial palsy).

Also called: Bilateral facial weakness, Facial paresis, bilateral
Body system: Abnormality of head or neck Abnormality of the musculoskeletal system Abnormality of the nervous system

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46 genes linked to Facial diplegia

Changes in these genes cause rare conditions in which Facial diplegia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
ADCY6adenylate cyclase 6	Always	In 1 condition
JPH1junctophilin 1	Always	In 1 condition
MPZmyelin protein zero	Always	In 1 condition
MTRFRmitochondrial translation release factor in rescue	Always	In 2 conditions
CNTNAP1contactin associated protein 1	Often (30–79%)	In 2 conditions
CRPPACDP-L-ribitol pyrophosphorylase A	Often (30–79%)	In 1 condition
FKRPfukutin related protein	Often (30–79%)	In 1 condition
FKTNfukutin	Often (30–79%)	In 1 condition
POMT1protein O-mannosyltransferase 1	Often (30–79%)	In 1 condition
SCO2synthesis of cytochrome C oxidase 2	Often (30–79%)	In 1 condition
SLC12A6solute carrier family 12 member 6	Often (30–79%)	In 1 condition
YME1L1YME1 like 1 ATPase	Often (30–79%)	In 1 condition
ABCA1ATP binding cassette subfamily A member 1	Sometimes (5–29%)	In 2 conditions
ACTA1actin alpha 1, skeletal muscle	Sometimes (5–29%)	In 4 conditions
ADGRG1adhesion G protein-coupled receptor G1	Sometimes (5–29%)	In 1 condition
BIN1bridging integrator 1	Sometimes (5–29%)	In 1 condition
CFL2cofilin 2	Sometimes (5–29%)	In 1 condition
CRYABcrystallin alpha B	Sometimes (5–29%)	In 1 condition
EBF3EBF transcription factor 3	Sometimes (5–29%)	In 1 condition
KBTBD13kelch repeat and BTB domain containing 13	Sometimes (5–29%)	In 1 condition
KLHL40kelch like family member 40	Sometimes (5–29%)	In 1 condition
KLHL41kelch like family member 41	Sometimes (5–29%)	In 4 conditions
LMOD3leiomodin 3	Sometimes (5–29%)	In 2 conditions
MYPNmyopalladin	Sometimes (5–29%)	In 1 condition
NEBnebulin	Sometimes (5–29%)	In 4 conditions
NOTCH3notch receptor 3	Sometimes (5–29%)	In 1 condition
PI4KAphosphatidylinositol 4-kinase alpha	Sometimes (5–29%)	In 1 condition
POLGDNA polymerase gamma, catalytic subunit	Sometimes (5–29%)	In 1 condition
POLG2DNA polymerase gamma 2, accessory subunit	Sometimes (5–29%)	In 1 condition
RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B	Sometimes (5–29%)	In 1 condition
RYR1ryanodine receptor 1	Sometimes (5–29%)	In 2 conditions
SHMT2serine hydroxymethyltransferase 2	Sometimes (5–29%)	In 1 condition
SLC25A4solute carrier family 25 member 4	Sometimes (5–29%)	In 1 condition
SPEGstriated muscle enriched protein kinase	Sometimes (5–29%)	In 1 condition
SRPX2sushi repeat containing protein X-linked 2	Sometimes (5–29%)	In 1 condition
TPM2tropomyosin 2	Sometimes (5–29%)	In 3 conditions
TPM3tropomyosin 3	Sometimes (5–29%)	In 3 conditions
TTNtitin	Sometimes (5–29%)	In 1 condition
TWNKtwinkle mtDNA helicase	Sometimes (5–29%)	In 1 condition
VCPvalosin containing protein	Sometimes (5–29%)	In 1 condition

Show 6 more genes

Gene	How often it is seen	Conditions
DMPKDM1 protein kinase	Not recorded	In 1 condition
GLE1GLE1 RNA export mediator	Not recorded	In 1 condition
SLC52A3solute carrier family 52 member 3	Not recorded	In 1 condition
SOSTsclerostin	Not recorded	In 1 condition
SUCLA2succinate-CoA ligase ADP-forming subunit beta	Not recorded	In 1 condition
TK2thymidine kinase 2	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Bell's palsy

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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