Trait
Overactive lower leg reflex
Clinical name: Lower limb hyperreflexia
Increased intensity of the a reflex in the leg.
Summary
- Also called
- Brisk lower extremity reflexes, Hyperreflexia in lower limbs, Hyperreflexia in the lower limbs, Increased deep tendon reflexes in the lower limbs, Leg hyperreflexia
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test79 genes linked to Overactive lower leg reflex
Changes in these genes cause rare conditions in which Overactive lower leg reflex is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Always | In 4 conditions |
| AMFRautocrine motility factor receptor | Always | In 1 condition |
| CAPN1calpain 1 | Always | In 2 conditions |
| CLDN11claudin 11 | Always | In 1 condition |
| CYP2U1cytochrome P450 family 2 subfamily U member 1 | Always | In 2 conditions |
| FARS2phenylalanyl-tRNA synthetase 2, mitochondrial | Always | In 2 conditions |
| GLULglutamate-ammonia ligase | Always | In 1 condition |
| HPDL4-hydroxyphenylpyruvate dioxygenase like | Always | In 1 condition |
| KIF1Akinesin family member 1A | Always | In 2 conditions |
| KLC4kinesin light chain 4 | Always | In 1 condition |
| KPNA3karyopherin subunit alpha 3 | Always | In 1 condition |
| LARGE1LARGE xylosyl- and glucuronyltransferase 1 | Always | In 1 condition |
| LBRlamin B receptor | Always | In 1 condition |
| NOTCH3notch receptor 3 | Always | In 1 condition |
| REEP2receptor accessory protein 2 | Always | In 2 conditions |
| RTN2reticulon 2 | Always | In 1 condition |
| SELENOIselenoprotein I | Always | In 1 condition |
| SPG7SPG7 matrix AAA peptidase subunit, paraplegin | Always | In 2 conditions |
| TMEM63Ctransmembrane protein 63C | Always | In 1 condition |
| UBAP1ubiquitin associated protein 1 | Always | In 1 condition |
| VCPvalosin containing protein | Always | In 1 condition |
| VLDLRvery low density lipoprotein receptor | Always | In 1 condition |
| VPS11VPS11 core subunit of CORVET and HOPS complexes | Always | In 1 condition |
| WASHC5WASH complex subunit 5 | Always | In 1 condition |
| AFG3L2AFG3 like matrix AAA peptidase subunit 2 | Very often (80–99%) | In 2 conditions |
| ATL1atlastin GTPase 1 | Very often (80–99%) | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Very often (80–99%) | In 1 condition |
| COQ4coenzyme Q4 | Very often (80–99%) | In 1 condition |
| ERLIN1ER lipid raft associated 1 | Very often (80–99%) | In 1 condition |
| KIF1Ckinesin family member 1C | Very often (80–99%) | In 1 condition |
| KIF5Akinesin family member 5A | Very often (80–99%) | In 1 condition |
| NIPA1NIPA magnesium transporter 1 | Very often (80–99%) | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Very often (80–99%) | In 1 condition |
| TNRtenascin R | Very often (80–99%) | In 1 condition |
| ABCC9ATP binding cassette subfamily C member 9 | Often (30–79%) | In 1 condition |
| DKK1dickkopf Wnt signaling pathway inhibitor 1 | Often (30–79%) | In 1 condition |
| DLATdihydrolipoamide S-acetyltransferase | Often (30–79%) | In 1 condition |
| EBF3EBF transcription factor 3 | Often (30–79%) | In 1 condition |
| GCH1GTP cyclohydrolase 1 | Often (30–79%) | In 1 condition |
| IFRD1interferon related developmental regulator 1 | Often (30–79%) | In 1 condition |
Show 39 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| IMPDH2inosine monophosphate dehydrogenase 2 | Often (30–79%) | In 1 condition |
| INPP4Ainositol polyphosphate-4-phosphatase type I A | Often (30–79%) | In 1 condition |
| KYkyphoscoliosis peptidase | Often (30–79%) | In 1 condition |
| LYRM4LYR motif containing 4 | Often (30–79%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Often (30–79%) | In 1 condition |
| MKS1MKS transition zone complex subunit 1 | Often (30–79%) | In 1 condition |
| MSL3MSL complex subunit 3 | Often (30–79%) | In 1 condition |
| MT-TEmitochondrially encoded tRNA-Glu (GAA/G) | Often (30–79%) | In 1 condition |
| MTRFRmitochondrial translation release factor in rescue | Often (30–79%) | In 1 condition |
| NR4A2nuclear receptor subfamily 4 group A member 2 | Often (30–79%) | In 1 condition |
| OCA2OCA2 melanosomal transmembrane protein | Often (30–79%) | In 1 condition |
| RAB3ARAB3A, member RAS oncogene family | Often (30–79%) | In 1 condition |
| REEP1receptor accessory protein 1 | Often (30–79%) | In 1 condition |
| RUBCNrubicon autophagy regulator | Often (30–79%) | In 1 condition |
| THtyrosine hydroxylase | Often (30–79%) | In 1 condition |
| TSPOAP1TSPO associated protein 1 | Often (30–79%) | In 1 condition |
| UBE3Aubiquitin protein ligase E3A | Often (30–79%) | In 3 conditions |
| UCHL1ubiquitin C-terminal hydrolase L1 | Often (30–79%) | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Often (30–79%) | In 1 condition |
| ZFYVE26zinc finger FYVE-type containing 26 | Often (30–79%) | In 1 condition |
| FTLferritin light chain | Sometimes (5–29%) | In 1 condition |
| GJB1gap junction protein beta 1 | Sometimes (5–29%) | In 2 conditions |
| PLXNA1plexin A1 | Sometimes (5–29%) | In 1 condition |
| RARS1arginyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Sometimes (5–29%) | In 1 condition |
| TAF1TATA-box binding protein associated factor 1 | Sometimes (5–29%) | In 1 condition |
| TRRAPtransformation/transcription domain associated protein | Sometimes (5–29%) | In 1 condition |
| UFC1ubiquitin-fold modifier conjugating enzyme 1 | Sometimes (5–29%) | In 1 condition |
| ZNF142zinc finger protein 142 | Sometimes (5–29%) | In 1 condition |
| SPTAN1spectrin alpha, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| APOEapolipoprotein E | Not recorded | In 1 condition |
| DPM1dolichyl-phosphate mannosyltransferase subunit 1, catalytic | Not recorded | In 1 condition |
| KDM5Clysine demethylase 5C | Not recorded | In 1 condition |
| PDE8Bphosphodiesterase 8B | Not recorded | In 1 condition |
| PSEN1presenilin 1 | Not recorded | In 1 condition |
| SLC33A1solute carrier family 33 member 1 | Not recorded | In 1 condition |
| ST3GAL5ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | Not recorded | In 1 condition |
| SUMF1sulfatase modifying factor 1 | Not recorded | In 1 condition |
| TREX1three prime repair exonuclease 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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