Trait
Difficulty walking up stairs
Clinical name: Difficulty climbing stairs
Reduced ability to climb stairs.
Summary
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
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Get my Genome Test75 genes linked to Difficulty walking up stairs
Changes in these genes cause rare conditions in which Difficulty walking up stairs is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BAG3BAG cochaperone 3 | Always | In 1 condition |
| COL6A1collagen type VI alpha 1 chain | Always | In 1 condition |
| DAG1dystroglycan 1 | Always | In 2 conditions |
| DMDdystrophin | Always | In 2 conditions |
| GAAalpha glucosidase | Always | In 2 conditions |
| HSPB8heat shock protein family B (small) member 8 | Always | In 1 condition |
| INPP4Ainositol polyphosphate-4-phosphatase type I A | Always | In 1 condition |
| LMNAlamin A/C | Always | In 1 condition |
| LRIF1ligand dependent nuclear receptor interacting factor 1 | Always | In 1 condition |
| MEGF10multiple EGF like domains 10 | Always | In 1 condition |
| MIEF2mitochondrial elongation factor 2 | Always | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Always | In 3 conditions |
| POMKprotein O-mannose kinase | Always | In 1 condition |
| POMT1protein O-mannosyltransferase 1 | Always | In 2 conditions |
| RYR3ryanodine receptor 3 | Always | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Always | In 1 condition |
| SGCDsarcoglycan delta | Always | In 1 condition |
| SNUPNsnurportin 1 | Always | In 1 condition |
| SPTAN1spectrin alpha, non-erythrocytic 1 | Always | In 1 condition |
| TFGtrafficking from ER to golgi regulator | Always | In 1 condition |
| TNNT1troponin T1, slow skeletal type | Always | In 2 conditions |
| TRIM63tripartite motif containing 63 | Always | In 1 condition |
| TTNtitin | Always | In 3 conditions |
| ACTA1actin alpha 1, skeletal muscle | Very often (80–99%) | In 1 condition |
| PYROXD1pyridine nucleotide-disulphide oxidoreductase domain 1 | Very often (80–99%) | In 1 condition |
| ADSS1adenylosuccinate synthase 1 | Often (30–79%) | In 1 condition |
| BIN1bridging integrator 1 | Often (30–79%) | In 1 condition |
| DNAJB6DnaJ heat shock protein family (Hsp40) member B6 | Often (30–79%) | In 2 conditions |
| DYSFdysferlin | Often (30–79%) | In 4 conditions |
| FLNCfilamin C | Often (30–79%) | In 2 conditions |
| GMPPBGDP-mannose pyrophosphorylase B | Often (30–79%) | In 3 conditions |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Often (30–79%) | In 1 condition |
| HADHBhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | Often (30–79%) | In 1 condition |
| LAMA2laminin subunit alpha 2 | Often (30–79%) | In 1 condition |
| LIPElipase E, hormone sensitive type | Often (30–79%) | In 1 condition |
| LRP12LDL receptor related protein 12 | Often (30–79%) | In 1 condition |
| MFN2mitofusin 2 | Often (30–79%) | In 1 condition |
| MT-TEmitochondrially encoded tRNA-Glu (GAA/G) | Often (30–79%) | In 1 condition |
| MYOTmyotilin | Often (30–79%) | In 1 condition |
| PLECplectin | Often (30–79%) | In 2 conditions |
Show 35 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| POMT2protein O-mannosyltransferase 2 | Often (30–79%) | In 1 condition |
| RNASEH1ribonuclease H1 | Often (30–79%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Often (30–79%) | In 2 conditions |
| RYR1ryanodine receptor 1 | Often (30–79%) | In 1 condition |
| SGCAsarcoglycan alpha | Often (30–79%) | In 1 condition |
| SGCGsarcoglycan gamma | Often (30–79%) | In 1 condition |
| SPEGstriated muscle enriched protein kinase | Often (30–79%) | In 1 condition |
| TNPO3transportin 3 | Often (30–79%) | In 1 condition |
| TOR1AIP1torsin 1A interacting protein 1 | Often (30–79%) | In 1 condition |
| VAPBVAMP associated protein B and C | Often (30–79%) | In 1 condition |
| ALG14ALG14 UDP-N-acetylglucosaminyltransferase subunit | Sometimes (5–29%) | In 1 condition |
| ALG2ALG2 alpha-1,3/1,6-mannosyltransferase | Sometimes (5–29%) | In 1 condition |
| CAPN3calpain 3 | Sometimes (5–29%) | In 1 condition |
| DNA2DNA replication helicase/nuclease 2 | Sometimes (5–29%) | In 1 condition |
| DPAGT1dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 | Sometimes (5–29%) | In 1 condition |
| FKRPfukutin related protein | Sometimes (5–29%) | In 3 conditions |
| GFPT1glutamine--fructose-6-phosphate transaminase 1 | Sometimes (5–29%) | In 1 condition |
| GYS1glycogen synthase 1 | Sometimes (5–29%) | In 1 condition |
| MYH7myosin heavy chain 7 | Sometimes (5–29%) | In 1 condition |
| MYPNmyopalladin | Sometimes (5–29%) | In 1 condition |
| PHKA1phosphorylase kinase regulatory subunit alpha 1 | Sometimes (5–29%) | In 1 condition |
| PHKG1phosphorylase kinase catalytic subunit gamma 1 | Sometimes (5–29%) | In 1 condition |
| POLG2DNA polymerase gamma 2, accessory subunit | Sometimes (5–29%) | In 1 condition |
| SLC25A4solute carrier family 25 member 4 | Sometimes (5–29%) | In 1 condition |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 1 condition |
| TPM3tropomyosin 3 | Sometimes (5–29%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Sometimes (5–29%) | In 2 conditions |
| VCPvalosin containing protein | Sometimes (5–29%) | In 2 conditions |
| WDR62WD repeat domain 62 | Sometimes (5–29%) | In 1 condition |
| ANO5anoctamin 5 | Not recorded | In 1 condition |
| KBTBD13kelch repeat and BTB domain containing 13 | Not recorded | In 1 condition |
| PLEKHG5pleckstrin homology and RhoGEF domain containing G5 | Not recorded | In 1 condition |
| POMGNT1protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | Not recorded | In 1 condition |
| TCAPtitin-cap | Not recorded | In 1 condition |
| VMA21vacuolar ATPase assembly factor VMA21 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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