Trait
Recurrent fractures
The repeated occurrence of bone fractures (implying an abnormally increased tendency for fracture).
Summary
- Also called
- Increased fracture rate, Increased fractures, Multiple fractures, Multiple spontaneous fractures, Varying degree of multiple fractures, Frequent fractures
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
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Get my Genome Test138 genes linked to Recurrent fractures
Changes in these genes cause rare conditions in which Recurrent fractures is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| B3GALT6beta-1,3-galactosyltransferase 6 | Always | In 2 conditions |
| CCDC134coiled-coil domain containing 134 | Always | In 1 condition |
| COL11A1collagen type XI alpha 1 chain | Always | In 1 condition |
| COL1A1collagen type I alpha 1 chain | Always | In 5 conditions |
| CREB3L1cAMP responsive element binding protein 3 like 1 | Always | In 1 condition |
| CRTAPcartilage associated protein | Always | In 2 conditions |
| CYP27B1cytochrome P450 family 27 subfamily B member 1 | Always | In 1 condition |
| FKBP10FKBP prolyl isomerase 10 | Always | In 2 conditions |
| IFITM5interferon induced transmembrane protein 5 | Always | In 1 condition |
| IRX5iroquois homeobox 5 | Always | In 1 condition |
| LBRlamin B receptor | Always | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Always | In 1 condition |
| MIR2861microRNA 2861 | Always | In 1 condition |
| P3H1prolyl 3-hydroxylase 1 | Always | In 1 condition |
| P4HBprolyl 4-hydroxylase subunit beta | Always | In 2 conditions |
| PLEKHM1pleckstrin homology and RUN domain containing M1 | Always | In 2 conditions |
| PPIBpeptidylprolyl isomerase B | Always | In 1 condition |
| SEC24DSEC24 homolog D, COPII component | Always | In 2 conditions |
| SERPINF1serpin family F member 1 | Always | In 1 condition |
| SLC34A1solute carrier family 34 member 1 | Always | In 1 condition |
| SP7Sp7 transcription factor | Always | In 1 condition |
| SPARCsecreted protein acidic and cysteine rich | Always | In 1 condition |
| TENT5Aterminal nucleotidyltransferase 5A | Always | In 1 condition |
| UNC45Aunc-45 myosin chaperone A | Always | In 1 condition |
| WNT1Wnt family member 1 | Always | In 2 conditions |
| ANTXR2ANTXR cell adhesion molecule 2 | Very often (80–99%) | In 1 condition |
| CASRcalcium sensing receptor | Very often (80–99%) | In 2 conditions |
| CBScystathionine beta-synthase | Very often (80–99%) | In 1 condition |
| CLCN7Cl-/H+ antiporter 7 | Very often (80–99%) | In 5 conditions |
| COL1A2collagen type I alpha 2 chain | Very often (80–99%) | In 4 conditions |
| DKK1dickkopf Wnt signaling pathway inhibitor 1 | Very often (80–99%) | In 1 condition |
| GORABgolgin, RAB6 interacting | Very often (80–99%) | In 2 conditions |
| OSTM1osteoclastogenesis associated transmembrane protein 1 | Very often (80–99%) | In 1 condition |
| PLOD2procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 | Very often (80–99%) | In 1 condition |
| PYCR1pyrroline-5-carboxylate reductase 1 | Very often (80–99%) | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Very often (80–99%) | In 2 conditions |
| SNX10sorting nexin 10 | Very often (80–99%) | In 1 condition |
| SOX9SRY-box transcription factor 9 | Very often (80–99%) | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Very often (80–99%) | In 3 conditions |
| TMEM38Btransmembrane protein 38B | Very often (80–99%) | In 1 condition |
Show 98 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| TNFRSF11ATNF receptor superfamily member 11a | Very often (80–99%) | In 2 conditions |
| TNFRSF11BTNF receptor superfamily member 11b | Very often (80–99%) | In 2 conditions |
| TNFSF11TNF superfamily member 11 | Very often (80–99%) | In 2 conditions |
| TRPV6transient receptor potential cation channel subfamily V member 6 | Very often (80–99%) | In 2 conditions |
| VCPvalosin containing protein | Very often (80–99%) | In 1 condition |
| VDRvitamin D receptor | Very often (80–99%) | In 2 conditions |
| WNT3AWnt family member 3A | Very often (80–99%) | In 1 condition |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Often (30–79%) | In 1 condition |
| ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2 | Often (30–79%) | In 1 condition |
| ADAMTSL2ADAMTS like 2 | Often (30–79%) | In 1 condition |
| B3GAT3beta-1,3-glucuronyltransferase 3 | Often (30–79%) | In 1 condition |
| BMP1bone morphogenetic protein 1 | Often (30–79%) | In 1 condition |
| CA2carbonic anhydrase 2 | Often (30–79%) | In 1 condition |
| CHD6chromodomain helicase DNA binding protein 6 | Often (30–79%) | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Often (30–79%) | In 1 condition |
| CLTCL1clathrin heavy chain like 1 | Often (30–79%) | In 1 condition |
| COPB2coat protein complex I subunit beta 2 | Often (30–79%) | In 1 condition |
| CTC1CST telomere replication complex component 1 | Often (30–79%) | In 1 condition |
| DKC1dyskerin pseudouridine synthase 1 | Often (30–79%) | In 1 condition |
| EMILIN1elastin microfibril interfacer 1 | Often (30–79%) | In 1 condition |
| GLE1GLE1 RNA export mediator | Often (30–79%) | In 1 condition |
| LIFRLIF receptor subunit alpha | Often (30–79%) | In 1 condition |
| LRP5LDL receptor related protein 5 | Often (30–79%) | In 2 conditions |
| LRRC8Cleucine rich repeat containing 8 VRAC subunit C | Often (30–79%) | In 1 condition |
| NGFnerve growth factor | Often (30–79%) | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Often (30–79%) | In 1 condition |
| NOP10NOP10 ribonucleoprotein | Often (30–79%) | In 1 condition |
| NOTCH2notch receptor 2 | Often (30–79%) | In 1 condition |
| NPM1nucleophosmin 1 | Often (30–79%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Often (30–79%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Often (30–79%) | In 1 condition |
| PHLDB1pleckstrin homology like domain family B member 1 | Often (30–79%) | In 1 condition |
| POT1protection of telomeres 1 | Often (30–79%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Often (30–79%) | In 1 condition |
| SMSspermine synthase | Often (30–79%) | In 2 conditions |
| STAT3signal transducer and activator of transcription 3 | Often (30–79%) | In 2 conditions |
| TERCtelomerase RNA component | Often (30–79%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Often (30–79%) | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Often (30–79%) | In 1 condition |
| TRIP11thyroid hormone receptor interactor 11 | Often (30–79%) | In 1 condition |
| TYMSthymidylate synthetase | Often (30–79%) | In 1 condition |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| WRAP53WD repeat containing antisense to TP53 | Often (30–79%) | In 1 condition |
| ANO5anoctamin 5 | Sometimes (5–29%) | In 1 condition |
| ANOS1anosmin 1 | Sometimes (5–29%) | In 1 condition |
| ATP7AATPase copper transporting alpha | Sometimes (5–29%) | In 1 condition |
| B4GALT7beta-1,4-galactosyltransferase 7 | Sometimes (5–29%) | In 1 condition |
| CCDC141coiled-coil domain containing 141 | Sometimes (5–29%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Sometimes (5–29%) | In 1 condition |
| CTNND2catenin delta 2 | Sometimes (5–29%) | In 1 condition |
| DCCDCC netrin 1 receptor | Sometimes (5–29%) | In 1 condition |
| DUSP6dual specificity phosphatase 6 | Sometimes (5–29%) | In 1 condition |
| ELP1elongator acetyltransferase complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| EMX2empty spiracles homeobox 2 | Sometimes (5–29%) | In 1 condition |
| FEZF1FEZ family zinc finger 1 | Sometimes (5–29%) | In 1 condition |
| FGF17fibroblast growth factor 17 | Sometimes (5–29%) | In 1 condition |
| FGF8fibroblast growth factor 8 | Sometimes (5–29%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Sometimes (5–29%) | In 1 condition |
| FLRT3fibronectin leucine rich transmembrane protein 3 | Sometimes (5–29%) | In 1 condition |
| FOXE1forkhead box E1 | Sometimes (5–29%) | In 1 condition |
| GNASGNAS complex locus | Sometimes (5–29%) | In 2 conditions |
| HABP2hyaluronan binding protein 2 | Sometimes (5–29%) | In 1 condition |
| HESX1HESX homeobox 1 | Sometimes (5–29%) | In 1 condition |
| HS6ST1heparan sulfate 6-O-sulfotransferase 1 | Sometimes (5–29%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Sometimes (5–29%) | In 1 condition |
| IDH2isocitrate dehydrogenase (NADP(+)) 2 | Sometimes (5–29%) | In 1 condition |
| IL17RDinterleukin 17 receptor D | Sometimes (5–29%) | In 1 condition |
| MINPP1multiple inositol-polyphosphate phosphatase 1 | Sometimes (5–29%) | In 1 condition |
| MYH3myosin heavy chain 3 | Sometimes (5–29%) | In 1 condition |
| NDNFneuron derived neurotrophic factor | Sometimes (5–29%) | In 1 condition |
| NFIXnuclear factor I X | Sometimes (5–29%) | In 1 condition |
| PDGFRBplatelet derived growth factor receptor beta | Sometimes (5–29%) | In 1 condition |
| PRDM5PR/SET domain 5 | Sometimes (5–29%) | In 1 condition |
| PROK2prokineticin 2 | Sometimes (5–29%) | In 1 condition |
| PROKR2prokineticin receptor 2 | Sometimes (5–29%) | In 1 condition |
| PTENphosphatase and tensin homolog | Sometimes (5–29%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Sometimes (5–29%) | In 1 condition |
| RUNX2RUNX family transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| SEMA3Asemaphorin 3A | Sometimes (5–29%) | In 1 condition |
| SEMA5Asemaphorin 5A | Sometimes (5–29%) | In 1 condition |
| SOX10SRY-box transcription factor 10 | Sometimes (5–29%) | In 1 condition |
| SPRY4sprouty RTK signaling antagonist 4 | Sometimes (5–29%) | In 1 condition |
| TACR3tachykinin receptor 3 | Sometimes (5–29%) | In 1 condition |
| WDR11WD repeat domain 11 | Sometimes (5–29%) | In 1 condition |
| ALPLalkaline phosphatase, biomineralization associated | Not recorded | In 1 condition |
| CLCN5Cl-/H+ antiporter 5 | Not recorded | In 2 conditions |
| CYP2R1cytochrome P450 family 2 subfamily R member 1 | Not recorded | In 1 condition |
| FZD4frizzled class receptor 4 | Not recorded | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| KDELR2KDEL endoplasmic reticulum protein retention receptor 2 | Not recorded | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| MOGSmannosyl-oligosaccharide glucosidase | Not recorded | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Not recorded | In 1 condition |
| SGMS2sphingomyelin synthase 2 | Not recorded | In 1 condition |
| SLC34A3solute carrier family 34 member 3 | Not recorded | In 1 condition |
| SLC7A7solute carrier family 7 member 7 | Not recorded | In 1 condition |
| YY1AP1YY1 associated protein 1 | Not recorded | In 1 condition |
| ZNF687zinc finger protein 687 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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