Trait
Senile plaques
Senile plaques are extracellular deposits of amyloid in the gray matter of the brain.
Summary
- Also called
- Braindruse, Neuritic plaques, Senile druse
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test11 genes linked to Senile plaques
Changes in these genes cause rare conditions in which Senile plaques is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| MAPTmicrotubule associated protein tau | Always | In 2 conditions |
| PRNPprion protein (Kanno blood group) | Often (30–79%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Sometimes (5–29%) | In 1 condition |
| GRNgranulin precursor | Sometimes (5–29%) | In 1 condition |
| PSEN1presenilin 1 | Sometimes (5–29%) | In 1 condition |
| TMEM106Btransmembrane protein 106B | Sometimes (5–29%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Sometimes (5–29%) | In 2 conditions |
| VCPvalosin containing protein | Sometimes (5–29%) | In 1 condition |
| ABCA7ATP binding cassette subfamily A member 7 | Not recorded | In 1 condition |
| APOEapolipoprotein E | Not recorded | In 1 condition |
| PSEN2presenilin 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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