Trait
Language impairment
Language impairment is a deficit in comprehension or production of language that includes reduced vocabulary, limited sentence structure, or impairments in written or spoken communication. Language abilities are substantially and quantifiably below age expectations.
Summary
- Also called
- Language disorder
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test80 genes linked to Language impairment
Changes in these genes cause rare conditions in which Language impairment is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCB7ATP binding cassette subfamily B member 7 | Always | In 1 condition |
| ADGRG1adhesion G protein-coupled receptor G1 | Always | In 3 conditions |
| BCKDKbranched chain keto acid dehydrogenase kinase | Always | In 1 condition |
| FOXP1forkhead box P1 | Always | In 1 condition |
| GATAD2BGATA zinc finger domain containing 2B | Always | In 1 condition |
| APPamyloid beta precursor protein | Very often (80–99%) | In 1 condition |
| BCRBCR activator of RhoGEF and GTPase | Very often (80–99%) | In 1 condition |
| CRKLCRK like proto-oncogene, adaptor protein | Very often (80–99%) | In 1 condition |
| DCXdoublecortin | Very often (80–99%) | In 1 condition |
| GRIN2Aglutamate ionotropic receptor NMDA type subunit 2A | Very often (80–99%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Very often (80–99%) | In 1 condition |
| PSEN1presenilin 1 | Very often (80–99%) | In 3 conditions |
| PSEN2presenilin 2 | Very often (80–99%) | In 1 condition |
| SORL1sortilin related receptor 1 | Very often (80–99%) | In 1 condition |
| TOMM40translocase of outer mitochondrial membrane 40 | Very often (80–99%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Very often (80–99%) | In 2 conditions |
| GRHL3grainyhead like transcription factor 3 | Often (30–79%) | In 1 condition |
| NF1neurofibromin 1 | Often (30–79%) | In 1 condition |
| PAFAH1B1platelet activating factor acetylhydrolase 1b regulatory subunit 1 | Often (30–79%) | In 1 condition |
| PI4KAphosphatidylinositol 4-kinase alpha | Often (30–79%) | In 1 condition |
| PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta | Often (30–79%) | In 1 condition |
| SRPX2sushi repeat containing protein X-linked 2 | Often (30–79%) | In 1 condition |
| UBBubiquitin B | Often (30–79%) | In 1 condition |
| ANGangiogenin | Sometimes (5–29%) | In 1 condition |
| ANXA11annexin A11 | Sometimes (5–29%) | In 1 condition |
| ATP1A2ATPase Na+/K+ transporting subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| ATXN2ataxin 2 | Sometimes (5–29%) | In 1 condition |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Sometimes (5–29%) | In 1 condition |
| CCNFcyclin F | Sometimes (5–29%) | In 1 condition |
| CFAP410cilia and flagella associated protein 410 | Sometimes (5–29%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Sometimes (5–29%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Sometimes (5–29%) | In 1 condition |
| CPLX1complexin 1 | Sometimes (5–29%) | In 1 condition |
| DAOD-amino acid oxidase | Sometimes (5–29%) | In 1 condition |
| DCTN1dynactin subunit 1 | Sometimes (5–29%) | In 1 condition |
| EHMT1euchromatic histone lysine methyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| ERBB4erb-b2 receptor tyrosine kinase 4 | Sometimes (5–29%) | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Sometimes (5–29%) | In 1 condition |
| FUSFUS RNA binding protein | Sometimes (5–29%) | In 1 condition |
| GJB1gap junction protein beta 1 | Sometimes (5–29%) | In 1 condition |
Show 40 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| GLE1GLE1 RNA export mediator | Sometimes (5–29%) | In 1 condition |
| GLT8D1glycosyltransferase 8 domain containing 1 | Sometimes (5–29%) | In 1 condition |
| HNF1BHNF1 homeobox B | Sometimes (5–29%) | In 1 condition |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Sometimes (5–29%) | In 2 conditions |
| HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B1 | Sometimes (5–29%) | In 1 condition |
| KMT2Clysine methyltransferase 2C | Sometimes (5–29%) | In 1 condition |
| LHX1LIM homeobox 1 | Sometimes (5–29%) | In 1 condition |
| LRP12LDL receptor related protein 12 | Sometimes (5–29%) | In 1 condition |
| MATR3matrin 3 | Sometimes (5–29%) | In 1 condition |
| NEFHneurofilament heavy chain | Sometimes (5–29%) | In 1 condition |
| NEK1NIMA related kinase 1 | Sometimes (5–29%) | In 1 condition |
| NOTCH3notch receptor 3 | Sometimes (5–29%) | In 1 condition |
| OPTNoptineurin | Sometimes (5–29%) | In 1 condition |
| PFN1profilin 1 | Sometimes (5–29%) | In 1 condition |
| PRPHperipherin | Sometimes (5–29%) | In 1 condition |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Sometimes (5–29%) | In 1 condition |
| PRRT2proline rich transmembrane protein 2 | Sometimes (5–29%) | In 1 condition |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Sometimes (5–29%) | In 1 condition |
| SCN8Asodium voltage-gated channel alpha subunit 8 | Sometimes (5–29%) | In 1 condition |
| SOD1superoxide dismutase 1 | Sometimes (5–29%) | In 1 condition |
| SQSTM1sequestosome 1 | Sometimes (5–29%) | In 2 conditions |
| TAF15TATA-box binding protein associated factor 15 | Sometimes (5–29%) | In 1 condition |
| TARDBPTAR DNA binding protein | Sometimes (5–29%) | In 1 condition |
| TBC1D24TBC1 domain family member 24 | Sometimes (5–29%) | In 1 condition |
| TBK1TANK binding kinase 1 | Sometimes (5–29%) | In 2 conditions |
| UBQLN2ubiquilin 2 | Sometimes (5–29%) | In 1 condition |
| UNC13Aunc-13 homolog A | Sometimes (5–29%) | In 1 condition |
| VAPBVAMP associated protein B and C | Sometimes (5–29%) | In 1 condition |
| VCPvalosin containing protein | Sometimes (5–29%) | In 2 conditions |
| IRAK1interleukin 1 receptor associated kinase 1 | Rarely (1–4%) | In 1 condition |
| SAT1spermidine/spermine N1-acetyltransferase 1 | Rarely (1–4%) | In 1 condition |
| SPP1secreted phosphoprotein 1 | Rarely (1–4%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Rarely (1–4%) | In 1 condition |
| CNTNAP2contactin associated protein 2 | Not recorded | In 1 condition |
| FLCNfolliculin | Not recorded | In 1 condition |
| MAPTmicrotubule associated protein tau | Not recorded | In 2 conditions |
| MBD5methyl-CpG binding domain protein 5 | Not recorded | In 1 condition |
| RAI1retinoic acid induced 1 | Not recorded | In 1 condition |
| SYNGAP1synaptic Ras GTPase activating protein 1 | Not recorded | In 1 condition |
| TM4SF20transmembrane 4 L six family member 20 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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