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Trait
Excessive inward curvature of lower spine
Clinical name: Lumbar hyperlordosis
An abnormal accentuation of the inward curvature of the spine in the lumbar region.
Summary
- Also called
- Exaggerated lumbar lordosis, Increased lumbar lordosis, Lumbar lordosis, Prominent lumbar lordosis
- Body system
- Abnormality of the musculoskeletal system
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Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/traits/lumbar-hyperlordosis.json"
page <- fromJSON(url)
page$trait$nameWho We HelpOur ScienceProductsOutcomes
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Get my Genome Test109 genes linked to Excessive inward curvature of lower spine
Changes in these genes cause rare conditions in which Excessive inward curvature of lower spine is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACANaggrecan | Always | In 3 conditions |
| CLCF1cardiotrophin like cytokine factor 1 | Always | In 1 condition |
| COL11A2collagen type XI alpha 2 chain | Always | In 2 conditions |
| DAG1dystroglycan 1 | Always | In 2 conditions |
| DYMdymeclin | Always | In 1 condition |
| FLNAfilamin A | Always | In 1 condition |
| GARS1glycyl-tRNA synthetase 1 | Always | In 1 condition |
| GNPNAT1glucosamine-phosphate N-acetyltransferase 1 | Always | In 1 condition |
| HSPB8heat shock protein family B (small) member 8 | Always | In 1 condition |
| ITCHitchy E3 ubiquitin protein ligase | Always | In 1 condition |
| JPH1junctophilin 1 | Always | In 1 condition |
| KYkyphoscoliosis peptidase | Always | In 1 condition |
| MYH7myosin heavy chain 7 | Always | In 1 condition |
| OBSL1obscurin like cytoskeletal adaptor 1 | Always | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Always | In 2 conditions |
| SGSM3small G protein signaling modulator 3 | Always | In 1 condition |
| SLC13A1solute carrier family 13 member 1 | Always | In 1 condition |
| SMAD4SMAD family member 4 | Always | In 1 condition |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Always | In 2 conditions |
| TAF4TATA-box binding protein associated factor 4 | Always | In 1 condition |
| UNC13Aunc-13 homolog A | Always | In 1 condition |
| BGNbiglycan | Very often (80–99%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Very often (80–99%) | In 4 conditions |
| MATN3matrilin 3 | Very often (80–99%) | In 2 conditions |
| NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL | Very often (80–99%) | In 1 condition |
| PRG4proteoglycan 4 | Very often (80–99%) | In 1 condition |
| RYR1ryanodine receptor 1 | Very often (80–99%) | In 1 condition |
| ABCC9ATP binding cassette subfamily C member 9 | Often (30–79%) | In 1 condition |
| ACP5acid phosphatase 5, tartrate resistant | Often (30–79%) | In 1 condition |
| ALX3ALX homeobox 3 | Often (30–79%) | In 1 condition |
| ARSBarylsulfatase B | Often (30–79%) | In 1 condition |
| CFL2cofilin 2 | Often (30–79%) | In 1 condition |
| CHST11carbohydrate sulfotransferase 11 | Often (30–79%) | In 1 condition |
| COL10A1collagen type X alpha 1 chain | Often (30–79%) | In 2 conditions |
| COL27A1collagen type XXVII alpha 1 chain | Often (30–79%) | In 1 condition |
| COMPcartilage oligomeric matrix protein | Often (30–79%) | In 2 conditions |
| DMDdystrophin | Often (30–79%) | In 1 condition |
| DNM2dynamin 2 | Often (30–79%) | In 1 condition |
| EXTL3exostosin like glycosyltransferase 3 | Often (30–79%) | In 2 conditions |
| FGFR3fibroblast growth factor receptor 3 | Often (30–79%) | In 4 conditions |
Show 69 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| FKRPfukutin related protein | Often (30–79%) | In 1 condition |
| FLNBfilamin B | Often (30–79%) | In 1 condition |
| GMPPBGDP-mannose pyrophosphorylase B | Often (30–79%) | In 2 conditions |
| GSCgoosecoid homeobox | Often (30–79%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Often (30–79%) | In 1 condition |
| IHHIndian hedgehog signaling molecule | Often (30–79%) | In 1 condition |
| LIPElipase E, hormone sensitive type | Often (30–79%) | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Often (30–79%) | In 2 conditions |
| MTMR14myotubularin related protein 14 | Often (30–79%) | In 1 condition |
| MYBPC1myosin binding protein C1 | Often (30–79%) | In 1 condition |
| MYH3myosin heavy chain 3 | Often (30–79%) | In 1 condition |
| POLR3GLRNA polymerase III subunit GL | Often (30–79%) | In 1 condition |
| POMGNT1protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | Often (30–79%) | In 1 condition |
| POMKprotein O-mannose kinase | Often (30–79%) | In 1 condition |
| POMT1protein O-mannosyltransferase 1 | Often (30–79%) | In 3 conditions |
| POMT2protein O-mannosyltransferase 2 | Often (30–79%) | In 1 condition |
| PRKG2protein kinase cGMP-dependent 2 | Often (30–79%) | In 1 condition |
| SGCGsarcoglycan gamma | Often (30–79%) | In 1 condition |
| SLC26A2solute carrier family 26 member 2 | Often (30–79%) | In 3 conditions |
| SOX5SRY-box transcription factor 5 | Often (30–79%) | In 1 condition |
| TMEM63Ctransmembrane protein 63C | Often (30–79%) | In 1 condition |
| VAC14VAC14 component of PIKFYVE complex | Often (30–79%) | In 1 condition |
| AHDC1AT-hook DNA binding motif containing 1 | Sometimes (5–29%) | In 1 condition |
| ALG14ALG14 UDP-N-acetylglucosaminyltransferase subunit | Sometimes (5–29%) | In 1 condition |
| ALG2ALG2 alpha-1,3/1,6-mannosyltransferase | Sometimes (5–29%) | In 1 condition |
| AP1G1adaptor related protein complex 1 subunit gamma 1 | Sometimes (5–29%) | In 1 condition |
| ASH1LASH1 like histone lysine methyltransferase | Sometimes (5–29%) | In 1 condition |
| COL12A1collagen type XII alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL6A1collagen type VI alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL6A2collagen type VI alpha 2 chain | Sometimes (5–29%) | In 2 conditions |
| COL6A3collagen type VI alpha 3 chain | Sometimes (5–29%) | In 1 condition |
| DPAGT1dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 | Sometimes (5–29%) | In 1 condition |
| FN1fibronectin 1 | Sometimes (5–29%) | In 1 condition |
| GFPT1glutamine--fructose-6-phosphate transaminase 1 | Sometimes (5–29%) | In 1 condition |
| HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | Sometimes (5–29%) | In 1 condition |
| LTBP1latent transforming growth factor beta binding protein 1 | Sometimes (5–29%) | In 1 condition |
| MYPNmyopalladin | Sometimes (5–29%) | In 1 condition |
| REREarginine-glutamic acid dipeptide repeats | Sometimes (5–29%) | In 1 condition |
| SATB2SATB homeobox 2 | Sometimes (5–29%) | In 1 condition |
| SETBP1SET binding protein 1 | Sometimes (5–29%) | In 1 condition |
| SONSON DNA and RNA binding protein | Sometimes (5–29%) | In 1 condition |
| SYT1synaptotagmin 1 | Sometimes (5–29%) | In 1 condition |
| TOGARAM1TOG array regulator of axonemal microtubules 1 | Sometimes (5–29%) | In 1 condition |
| TONSLtonsoku like, DNA repair protein | Sometimes (5–29%) | In 2 conditions |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 1 condition |
| TPM3tropomyosin 3 | Sometimes (5–29%) | In 2 conditions |
| TRAPPC2trafficking protein particle complex subunit 2 | Sometimes (5–29%) | In 2 conditions |
| TRPV4transient receptor potential cation channel subfamily V member 4 | Sometimes (5–29%) | In 1 condition |
| VCPvalosin containing protein | Sometimes (5–29%) | In 2 conditions |
| VPS33AVPS33A core subunit of CORVET and HOPS complexes | Sometimes (5–29%) | In 1 condition |
| XYLT1xylosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| EBF3EBF transcription factor 3 | Rarely (1–4%) | In 1 condition |
| ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif 10 | Not recorded | In 1 condition |
| BCORBCL6 corepressor | Not recorded | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Not recorded | In 1 condition |
| DDRGK1DDRGK domain containing 1 | Not recorded | In 1 condition |
| FBN1fibrillin 1 | Not recorded | In 1 condition |
| FUCA1alpha-L-fucosidase 1 | Not recorded | In 1 condition |
| HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | Not recorded | In 1 condition |
| MED12mediator complex subunit 12 | Not recorded | In 1 condition |
| MFN2mitofusin 2 | Not recorded | In 1 condition |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Not recorded | In 1 condition |
| NPR2natriuretic peptide receptor 2 | Not recorded | In 1 condition |
| PCGF2polycomb group ring finger 2 | Not recorded | In 1 condition |
| PIEZO2piezo type mechanosensitive ion channel component 2 | Not recorded | In 1 condition |
| PLECplectin | Not recorded | In 1 condition |
| RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2 | Not recorded | In 1 condition |
| SHOXSHOX homeobox | Not recorded | In 1 condition |
| VPS13Bvacuolar protein sorting 13 homolog B | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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