Trait
Apraxia
A defect in the understanding of complex motor commands and in the execution of certain learned movements, i.e., deficits in the cognitive components of learned movements.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test62 genes linked to Apraxia
Changes in these genes cause rare conditions in which Apraxia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP6AP2ATPase H+ transporting accessory protein 2 | Always | In 2 conditions |
| CST3cystatin C | Always | In 1 condition |
| HMBShydroxymethylbilane synthase | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated | Always | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Always | In 2 conditions |
| TAF4TATA-box binding protein associated factor 4 | Always | In 1 condition |
| MAPTmicrotubule associated protein tau | Very often (80–99%) | In 2 conditions |
| APOEapolipoprotein E | Often (30–79%) | In 2 conditions |
| CDKL5cyclin dependent kinase like 5 | Often (30–79%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Often (30–79%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Often (30–79%) | In 1 condition |
| FUSFUS RNA binding protein | Often (30–79%) | In 1 condition |
| GABBR2gamma-aminobutyric acid type B receptor subunit 2 | Often (30–79%) | In 1 condition |
| GRNgranulin precursor | Often (30–79%) | In 2 conditions |
| NTNG1netrin G1 | Often (30–79%) | In 1 condition |
| PSEN1presenilin 1 | Often (30–79%) | In 3 conditions |
| PSEN2presenilin 2 | Often (30–79%) | In 2 conditions |
| SMC1Astructural maintenance of chromosomes 1A | Often (30–79%) | In 1 condition |
| SPG21SPG21 abhydrolase domain containing, maspardin | Often (30–79%) | In 2 conditions |
| SQSTM1sequestosome 1 | Often (30–79%) | In 1 condition |
| TARDBPTAR DNA binding protein | Often (30–79%) | In 1 condition |
| TBK1TANK binding kinase 1 | Often (30–79%) | In 1 condition |
| TMEM106Btransmembrane protein 106B | Often (30–79%) | In 1 condition |
| TNRtenascin R | Often (30–79%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Often (30–79%) | In 4 conditions |
| UBE3Aubiquitin protein ligase E3A | Often (30–79%) | In 1 condition |
| USP7ubiquitin specific peptidase 7 | Often (30–79%) | In 1 condition |
| VCPvalosin containing protein | Often (30–79%) | In 2 conditions |
| AARS2alanyl-tRNA synthetase 2, mitochondrial | Sometimes (5–29%) | In 1 condition |
| ABCC8ATP binding cassette subfamily C member 8 | Sometimes (5–29%) | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Sometimes (5–29%) | In 1 condition |
| APPamyloid beta precursor protein | Sometimes (5–29%) | In 1 condition |
| ARPC4actin related protein 2/3 complex subunit 4 | Sometimes (5–29%) | In 1 condition |
| GCKglucokinase | Sometimes (5–29%) | In 1 condition |
| GPAA1glycosylphosphatidylinositol anchor attachment 1 | Sometimes (5–29%) | In 1 condition |
| HECTD4HECT domain E3 ubiquitin protein ligase 4 | Sometimes (5–29%) | In 1 condition |
| HIVEP2HIVEP zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| INSinsulin | Sometimes (5–29%) | In 1 condition |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Sometimes (5–29%) | In 1 condition |
Show 22 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NKX2-1NK2 homeobox 1 | Sometimes (5–29%) | In 1 condition |
| NPTX1neuronal pentraxin 1 | Sometimes (5–29%) | In 1 condition |
| PDX1pancreatic and duodenal homeobox 1 | Sometimes (5–29%) | In 1 condition |
| SLC2A1solute carrier family 2 member 1 | Sometimes (5–29%) | In 1 condition |
| SNX14sorting nexin 14 | Sometimes (5–29%) | In 2 conditions |
| SORL1sortilin related receptor 1 | Sometimes (5–29%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Sometimes (5–29%) | In 1 condition |
| TIMM8Atranslocase of inner mitochondrial membrane 8A | Sometimes (5–29%) | In 1 condition |
| TOMM40translocase of outer mitochondrial membrane 40 | Sometimes (5–29%) | In 1 condition |
| SMPD1sphingomyelin phosphodiesterase 1 | Rarely (1–4%) | In 1 condition |
| ATP1A2ATPase Na+/K+ transporting subunit alpha 2 | Not recorded | In 1 condition |
| C9orf72C9orf72-SMCR8 complex subunit | Not recorded | In 1 condition |
| CSF1Rcolony stimulating factor 1 receptor | Not recorded | In 1 condition |
| EPM2AEPM2A glucan phosphatase, laforin | Not recorded | In 1 condition |
| FOXG1forkhead box G1 | Not recorded | In 1 condition |
| PRNPprion protein (Kanno blood group) | Not recorded | In 1 condition |
| TBPTATA-box binding protein | Not recorded | In 1 condition |
| TREX1three prime repair exonuclease 1 | Not recorded | In 1 condition |
| TTC19tetratricopeptide repeat domain 19 | Not recorded | In 1 condition |
| TYROBPtransmembrane immune signaling adaptor TYROBP | Not recorded | In 1 condition |
| XRCC4X-ray repair cross complementing 4 | Not recorded | In 1 condition |
| ZC4H2zinc finger C4H2-type containing | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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