Trait

Reduced vital capacity

An abnormal reduction on the vital capacity, which is defined as the total lung capacity (volume of air in the lungs at maximal inflation) less the residual volume (i.e., volume of air in the lungs following maximal exhalation) of the lung.

HPO HP:0002792

Also called: Decreased vital capacity
Body system: Abnormality of the respiratory system

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18 genes linked to Reduced vital capacity

Changes in these genes cause rare conditions in which Reduced vital capacity is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
SELENONselenoprotein N	Always	In 1 condition
CRPPACDP-L-ribitol pyrophosphorylase A	Often (30–79%)	In 1 condition
DOK7docking protein 7	Often (30–79%)	In 1 condition
MYPNmyopalladin	Often (30–79%)	In 2 conditions
TTNtitin	Often (30–79%)	In 2 conditions
ACTA1actin alpha 1, skeletal muscle	Sometimes (5–29%)	In 1 condition
KBTBD13kelch repeat and BTB domain containing 13	Sometimes (5–29%)	In 1 condition
KLHL41kelch like family member 41	Sometimes (5–29%)	In 1 condition
MAP3K20mitogen-activated protein kinase kinase kinase 20	Sometimes (5–29%)	In 1 condition
MYH7myosin heavy chain 7	Sometimes (5–29%)	In 1 condition
MYOTmyotilin	Sometimes (5–29%)	In 1 condition
NEBnebulin	Sometimes (5–29%)	In 1 condition
PYROXD1pyridine nucleotide-disulphide oxidoreductase domain 1	Sometimes (5–29%)	In 1 condition
SBF2SET binding factor 2	Sometimes (5–29%)	In 1 condition
TPM2tropomyosin 2	Sometimes (5–29%)	In 2 conditions
TPM3tropomyosin 3	Sometimes (5–29%)	In 1 condition
VCPvalosin containing protein	Rarely (1–4%)	In 1 condition
ACTN2actinin alpha 2	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality on pulmonary function testing

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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