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Trait
Spastic paraparesis
Partial loss of the ability to move the lower limbs accompanied by spasticity of the lower limbs.
Spastic paraparesisHP:0002313
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Read the genes linked to Spastic paraparesis, and the rest of your genome, with one test.
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Get my Genome Test89 genes linked to Spastic paraparesis
Changes in these genes cause rare conditions in which Spastic paraparesis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AFG3L2AFG3 like matrix AAA peptidase subunit 2 | Always | In 3 conditions |
| AIMP1aminoacyl tRNA synthetase complex interacting multifunctional protein 1 | Always | In 1 condition |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Always | In 2 conditions |
| FAR1fatty acyl-CoA reductase 1 | Always | In 1 condition |
| GJC2gap junction protein gamma 2 | Always | In 1 condition |
| HMBShydroxymethylbilane synthase | Always | In 1 condition |
| MAGmyelin associated glycoprotein | Always | In 1 condition |
| COASYCoenzyme A synthase | Very often (80–99%) | In 2 conditions |
| MTPAPmitochondrial poly(A) polymerase | Very often (80–99%) | In 2 conditions |
| AP5Z1adaptor related protein complex 5 subunit zeta 1 | Often (30–79%) | In 1 condition |
| CCDC88Ccoiled-coil and HOOK domain protein 88C | Often (30–79%) | In 2 conditions |
| GALCgalactosylceramidase | Often (30–79%) | In 1 condition |
| GFAPglial fibrillary acidic protein | Often (30–79%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Often (30–79%) | In 1 condition |
| GOT2glutamic-oxaloacetic transaminase 2 | Often (30–79%) | In 1 condition |
| MICOS13mitochondrial contact site and cristae organizing system subunit 13 | Often (30–79%) | In 1 condition |
| MTHFRmethylenetetrahydrofolate reductase | Often (30–79%) | In 1 condition |
| MTRFRmitochondrial translation release factor in rescue | Often (30–79%) | In 2 conditions |
| OPA3outer mitochondrial membrane lipid metabolism regulator OPA3 | Often (30–79%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 1 condition |
| POLR3GLRNA polymerase III subunit GL | Often (30–79%) | In 1 condition |
| SPARTspartin | Often (30–79%) | In 2 conditions |
| WDR45WD repeat domain 45 | Often (30–79%) | In 2 conditions |
| ADARadenosine deaminase RNA specific | Sometimes (5–29%) | In 1 condition |
| ANGangiogenin | Sometimes (5–29%) | In 1 condition |
| ANXA11annexin A11 | Sometimes (5–29%) | In 1 condition |
| ATP6AP2ATPase H+ transporting accessory protein 2 | Sometimes (5–29%) | In 1 condition |
| ATXN2ataxin 2 | Sometimes (5–29%) | In 1 condition |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 1 condition |
| BTDbiotinidase | Sometimes (5–29%) | In 1 condition |
| CCNFcyclin F | Sometimes (5–29%) | In 1 condition |
| CFAP410cilia and flagella associated protein 410 | Sometimes (5–29%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Sometimes (5–29%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Sometimes (5–29%) | In 1 condition |
| DAOD-amino acid oxidase | Sometimes (5–29%) | In 1 condition |
| DCTN1dynactin subunit 1 | Sometimes (5–29%) | In 1 condition |
| ERBB4erb-b2 receptor tyrosine kinase 4 | Sometimes (5–29%) | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Sometimes (5–29%) | In 1 condition |
| FUSFUS RNA binding protein | Sometimes (5–29%) | In 1 condition |
| GLE1GLE1 RNA export mediator | Sometimes (5–29%) | In 1 condition |
Show 49 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| GLT8D1glycosyltransferase 8 domain containing 1 | Sometimes (5–29%) | In 1 condition |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Sometimes (5–29%) | In 1 condition |
| IDUAalpha-L-iduronidase | Sometimes (5–29%) | In 2 conditions |
| IFIH1interferon induced with helicase C domain 1 | Sometimes (5–29%) | In 1 condition |
| LRP12LDL receptor related protein 12 | Sometimes (5–29%) | In 1 condition |
| LSM11LSM11, U7 small nuclear RNA associated | Sometimes (5–29%) | In 1 condition |
| MATR3matrin 3 | Sometimes (5–29%) | In 1 condition |
| MED13Lmediator complex subunit 13L | Sometimes (5–29%) | In 1 condition |
| NEFHneurofilament heavy chain | Sometimes (5–29%) | In 1 condition |
| NEK1NIMA related kinase 1 | Sometimes (5–29%) | In 1 condition |
| OPTNoptineurin | Sometimes (5–29%) | In 1 condition |
| PFN1profilin 1 | Sometimes (5–29%) | In 1 condition |
| PLP1proteolipid protein 1 | Sometimes (5–29%) | In 1 condition |
| PNPpurine nucleoside phosphorylase | Sometimes (5–29%) | In 1 condition |
| PPP1R15Bprotein phosphatase 1 regulatory subunit 15B | Sometimes (5–29%) | In 1 condition |
| PRPHperipherin | Sometimes (5–29%) | In 1 condition |
| RNASEH2Aribonuclease H2 subunit A | Sometimes (5–29%) | In 1 condition |
| RNASEH2Bribonuclease H2 subunit B | Sometimes (5–29%) | In 1 condition |
| RNASEH2Cribonuclease H2 subunit C | Sometimes (5–29%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Sometimes (5–29%) | In 1 condition |
| SDHAF1succinate dehydrogenase complex assembly factor 1 | Sometimes (5–29%) | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Sometimes (5–29%) | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Sometimes (5–29%) | In 1 condition |
| SLC30A10solute carrier family 30 member 10 | Sometimes (5–29%) | In 2 conditions |
| SOD1superoxide dismutase 1 | Sometimes (5–29%) | In 1 condition |
| SQSTM1sequestosome 1 | Sometimes (5–29%) | In 1 condition |
| TAF15TATA-box binding protein associated factor 15 | Sometimes (5–29%) | In 1 condition |
| TARDBPTAR DNA binding protein | Sometimes (5–29%) | In 1 condition |
| TBK1TANK binding kinase 1 | Sometimes (5–29%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Sometimes (5–29%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Sometimes (5–29%) | In 1 condition |
| TRMT10AtRNA methyltransferase 10A | Sometimes (5–29%) | In 1 condition |
| TTRtransthyretin | Sometimes (5–29%) | In 1 condition |
| UBQLN2ubiquilin 2 | Sometimes (5–29%) | In 1 condition |
| UNC13Aunc-13 homolog A | Sometimes (5–29%) | In 1 condition |
| VAPBVAMP associated protein B and C | Sometimes (5–29%) | In 1 condition |
| VCPvalosin containing protein | Sometimes (5–29%) | In 1 condition |
| CYP27A1cytochrome P450 family 27 subfamily A member 1 | Rarely (1–4%) | In 1 condition |
| PRUNE1prune exopolyphosphatase 1 | Rarely (1–4%) | In 1 condition |
| ARG1arginase 1 | Not recorded | In 1 condition |
| EDNRBendothelin receptor type B | Not recorded | In 1 condition |
| GBA1glucosylceramidase beta 1 | Not recorded | In 1 condition |
| PEX16peroxisomal biogenesis factor 16 | Not recorded | In 1 condition |
| SLC25A15solute carrier family 25 member 15 | Not recorded | In 1 condition |
| SOX10SRY-box transcription factor 10 | Not recorded | In 1 condition |
| SPG21SPG21 abhydrolase domain containing, maspardin | Not recorded | In 1 condition |
| TTC19tetratricopeptide repeat domain 19 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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