Trait
Partial paralysis of legs
Clinical name: Paraparesis
Weakness or partial paralysis in the lower limbs.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test27 genes linked to Partial paralysis of legs
Changes in these genes cause rare conditions in which Partial paralysis of legs is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| SPG11SPG11 vesicle trafficking associated, spatacsin | Very often (80–99%) | In 1 condition |
| ATP5F1AATP synthase F1 subunit alpha | Often (30–79%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Often (30–79%) | In 1 condition |
| CYP27A1cytochrome P450 family 27 subfamily A member 1 | Often (30–79%) | In 1 condition |
| FUSFUS RNA binding protein | Often (30–79%) | In 1 condition |
| NF1neurofibromin 1 | Often (30–79%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 1 condition |
| SQSTM1sequestosome 1 | Often (30–79%) | In 1 condition |
| TARDBPTAR DNA binding protein | Often (30–79%) | In 1 condition |
| TBK1TANK binding kinase 1 | Often (30–79%) | In 1 condition |
| VCPvalosin containing protein | Often (30–79%) | In 1 condition |
| ADGRG1adhesion G protein-coupled receptor G1 | Sometimes (5–29%) | In 1 condition |
| CLTCclathrin heavy chain | Sometimes (5–29%) | In 1 condition |
| GAMTguanidinoacetate N-methyltransferase | Sometimes (5–29%) | In 1 condition |
| PI4KAphosphatidylinositol 4-kinase alpha | Sometimes (5–29%) | In 1 condition |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Sometimes (5–29%) | In 1 condition |
| SP110SP110 nuclear body protein | Sometimes (5–29%) | In 1 condition |
| SRPX2sushi repeat containing protein X-linked 2 | Sometimes (5–29%) | In 1 condition |
| TTC19tetratricopeptide repeat domain 19 | Sometimes (5–29%) | In 1 condition |
| ASAH1N-acylsphingosine amidohydrolase 1 | Rarely (1–4%) | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Not recorded | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Not recorded | In 1 condition |
| C9orf72C9orf72-SMCR8 complex subunit | Not recorded | In 1 condition |
| GJA1gap junction protein alpha 1 | Not recorded | In 1 condition |
| GJB1gap junction protein beta 1 | Not recorded | In 1 condition |
| SLC19A3solute carrier family 19 member 3 | Not recorded | In 1 condition |
| TNFRSF11ATNF receptor superfamily member 11a | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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