Trait
Difficulty making arithmetical calculations
Clinical name: Dyscalculia
A specific learning disability involving mathematics and arithmetic.
Summary
- Also called
- Acalculia
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test23 genes linked to Difficulty making arithmetical calculations
Changes in these genes cause rare conditions in which Difficulty making arithmetical calculations is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CYLDCYLD lysine 63 deubiquitinase | Always | In 1 condition |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Always | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Very often (80–99%) | In 2 conditions |
| GRNgranulin precursor | Very often (80–99%) | In 1 condition |
| MAPTmicrotubule associated protein tau | Very often (80–99%) | In 1 condition |
| PSEN1presenilin 1 | Very often (80–99%) | In 1 condition |
| SQSTM1sequestosome 1 | Very often (80–99%) | In 2 conditions |
| TMEM106Btransmembrane protein 106B | Very often (80–99%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Very often (80–99%) | In 1 condition |
| VCPvalosin containing protein | Very often (80–99%) | In 3 conditions |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Often (30–79%) | In 1 condition |
| FUSFUS RNA binding protein | Often (30–79%) | In 1 condition |
| TARDBPTAR DNA binding protein | Often (30–79%) | In 1 condition |
| TBK1TANK binding kinase 1 | Often (30–79%) | In 1 condition |
| APC2APC regulator of Wnt signaling pathway 2 | Sometimes (5–29%) | In 1 condition |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Sometimes (5–29%) | In 1 condition |
| HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B1 | Sometimes (5–29%) | In 1 condition |
| MAP1Bmicrotubule associated protein 1B | Sometimes (5–29%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Sometimes (5–29%) | In 1 condition |
| PNKPpolynucleotide kinase 3'-phosphatase | Sometimes (5–29%) | In 1 condition |
| SRYsex determining region Y | Sometimes (5–29%) | In 1 condition |
| C9orf72C9orf72-SMCR8 complex subunit | Not recorded | In 1 condition |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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