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Trait
Waddling gait
Weakness of the hip girdle and upper thigh muscles, for instance in myopathies, leads to an instability of the pelvis on standing and walking. If the muscles extending the hip joint are affected, the posture in that joint becomes flexed and lumbar lordosis increases. The patients usually have difficulties standing up from a sitting position. Due to weakness in the gluteus medius muscle, the hip on the side of the swinging leg drops with each step (referred to as Trendelenburg sign). The gait appears waddling. The patients frequently attempt to counteract the dropping of the hip on the swinging side by bending the trunk towards the side which is in the stance phase (in the German language literature this is referred to as Duchenne sign). Similar gait patterns can be caused by orthopedic conditions when the origin and the insertion site of the gluteus medius muscle are closer to each other than normal, for instance due to a posttraumatic elevation of the trochanter or pseudarthrosis of the femoral neck.
Summary
- Also called
- Waddling walk
- Body system
- Abnormality of the nervous system
Waddling gaitHP:0002515
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Read the genes linked to Waddling gait, and the rest of your genome, with one test.
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Get my Genome Test129 genes linked to Waddling gait
Changes in these genes cause rare conditions in which Waddling gait is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACBD5acyl-CoA binding domain containing 5 | Always | In 1 condition |
| BGNbiglycan | Always | In 1 condition |
| BICD2BICD cargo adaptor 2 | Always | In 2 conditions |
| CCN2cellular communication network factor 2 | Always | In 1 condition |
| COL10A1collagen type X alpha 1 chain | Always | In 2 conditions |
| COL2A1collagen type II alpha 1 chain | Always | In 5 conditions |
| DMDdystrophin | Always | In 2 conditions |
| DPM3dolichyl-phosphate mannosyltransferase subunit 3, regulatory | Always | In 1 condition |
| DYMdymeclin | Always | In 2 conditions |
| DYNC1H1dynein cytoplasmic 1 heavy chain 1 | Always | In 2 conditions |
| FDX2ferredoxin 2 | Always | In 1 condition |
| FEM1Bfem-1 homolog B | Always | In 1 condition |
| FKBP14FKBP prolyl isomerase 14 | Always | In 1 condition |
| GALNSgalactosamine (N-acetyl)-6-sulfatase | Always | In 1 condition |
| HACD13-hydroxyacyl-CoA dehydratase 1 | Always | In 1 condition |
| HSPB8heat shock protein family B (small) member 8 | Always | In 1 condition |
| LMNAlamin A/C | Always | In 3 conditions |
| MBTPS1membrane bound transcription factor peptidase, site 1 | Always | In 1 condition |
| MYH2myosin heavy chain 2 | Always | In 1 condition |
| PHEXphosphate regulating endopeptidase X-linked | Always | In 1 condition |
| PREPLprolyl endopeptidase like | Always | In 1 condition |
| TRIM63tripartite motif containing 63 | Always | In 1 condition |
| TUBA4Atubulin alpha 4a | Always | In 1 condition |
| UFSP2UFM1 specific peptidase 2 | Always | In 1 condition |
| ACTA1actin alpha 1, skeletal muscle | Very often (80–99%) | In 5 conditions |
| CCN6cellular communication network factor 6 | Very often (80–99%) | In 2 conditions |
| CHST3carbohydrate sulfotransferase 3 | Very often (80–99%) | In 2 conditions |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Very often (80–99%) | In 1 condition |
| HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B1 | Very often (80–99%) | In 1 condition |
| LTBP4latent transforming growth factor beta binding protein 4 | Very often (80–99%) | In 1 condition |
| MATN3matrilin 3 | Very often (80–99%) | In 2 conditions |
| TRIM32tripartite motif containing 32 | Very often (80–99%) | In 2 conditions |
| VCPvalosin containing protein | Very often (80–99%) | In 1 condition |
| ANO5anoctamin 5 | Often (30–79%) | In 1 condition |
| AP4B1adaptor related protein complex 4 subunit beta 1 | Often (30–79%) | In 2 conditions |
| AP4E1adaptor related protein complex 4 subunit epsilon 1 | Often (30–79%) | In 1 condition |
| AP4M1adaptor related protein complex 4 subunit mu 1 | Often (30–79%) | In 1 condition |
| AP4S1adaptor related protein complex 4 subunit sigma 1 | Often (30–79%) | In 1 condition |
| ARHGAP19Rho GTPase activating protein 19 | Often (30–79%) | In 1 condition |
| BIN1bridging integrator 1 | Often (30–79%) | In 2 conditions |
Show 89 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CFL2cofilin 2 | Often (30–79%) | In 2 conditions |
| COL13A1collagen type XIII alpha 1 chain | Often (30–79%) | In 1 condition |
| COLQcollagen like tail subunit of asymmetric acetylcholinesterase | Often (30–79%) | In 1 condition |
| COMPcartilage oligomeric matrix protein | Often (30–79%) | In 4 conditions |
| DAG1dystroglycan 1 | Often (30–79%) | In 1 condition |
| DNAJB6DnaJ heat shock protein family (Hsp40) member B6 | Often (30–79%) | In 1 condition |
| DSTYKdual serine/threonine and tyrosine protein kinase | Often (30–79%) | In 1 condition |
| EMDemerin | Often (30–79%) | In 2 conditions |
| FHL1four and a half LIM domains 1 | Often (30–79%) | In 3 conditions |
| FKRPfukutin related protein | Often (30–79%) | In 2 conditions |
| GFPT1glutamine--fructose-6-phosphate transaminase 1 | Often (30–79%) | In 2 conditions |
| HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | Often (30–79%) | In 2 conditions |
| HSPG2heparan sulfate proteoglycan 2 | Often (30–79%) | In 1 condition |
| LAMB2laminin subunit beta 2 | Often (30–79%) | In 1 condition |
| LRP5LDL receptor related protein 5 | Often (30–79%) | In 1 condition |
| MUSKmuscle associated receptor tyrosine kinase | Often (30–79%) | In 1 condition |
| MYPNmyopalladin | Often (30–79%) | In 2 conditions |
| POMT1protein O-mannosyltransferase 1 | Often (30–79%) | In 1 condition |
| PTH1Rparathyroid hormone 1 receptor | Often (30–79%) | In 2 conditions |
| RYR1ryanodine receptor 1 | Often (30–79%) | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Often (30–79%) | In 2 conditions |
| SGCAsarcoglycan alpha | Often (30–79%) | In 1 condition |
| SGCBsarcoglycan beta | Often (30–79%) | In 1 condition |
| SGCGsarcoglycan gamma | Often (30–79%) | In 1 condition |
| SLC26A2solute carrier family 26 member 2 | Often (30–79%) | In 1 condition |
| SLC6A17solute carrier family 6 member 17 | Often (30–79%) | In 2 conditions |
| SMN1survival of motor neuron 1, telomeric | Often (30–79%) | In 1 condition |
| SPEGstriated muscle enriched protein kinase | Often (30–79%) | In 1 condition |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Often (30–79%) | In 1 condition |
| SYNE2spectrin repeat containing nuclear envelope protein 2 | Often (30–79%) | In 1 condition |
| SYT2synaptotagmin 2 | Often (30–79%) | In 1 condition |
| TGFB1transforming growth factor beta 1 | Often (30–79%) | In 2 conditions |
| TMEM43transmembrane protein 43 | Often (30–79%) | In 1 condition |
| TNNC2troponin C2, fast skeletal type | Often (30–79%) | In 1 condition |
| TNNT1troponin T1, slow skeletal type | Often (30–79%) | In 1 condition |
| TRAPPC10trafficking protein particle complex subunit 10 | Often (30–79%) | In 1 condition |
| TRAPPC11trafficking protein particle complex subunit 11 | Often (30–79%) | In 2 conditions |
| TRPV4transient receptor potential cation channel subfamily V member 4 | Often (30–79%) | In 2 conditions |
| TTNtitin | Often (30–79%) | In 1 condition |
| ALG14ALG14 UDP-N-acetylglucosaminyltransferase subunit | Sometimes (5–29%) | In 1 condition |
| ALG2ALG2 alpha-1,3/1,6-mannosyltransferase | Sometimes (5–29%) | In 2 conditions |
| ASAH1N-acylsphingosine amidohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| COL12A1collagen type XII alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL6A1collagen type VI alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL6A2collagen type VI alpha 2 chain | Sometimes (5–29%) | In 1 condition |
| COL6A3collagen type VI alpha 3 chain | Sometimes (5–29%) | In 1 condition |
| COL9A1collagen type IX alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL9A2collagen type IX alpha 2 chain | Sometimes (5–29%) | In 2 conditions |
| COL9A3collagen type IX alpha 3 chain | Sometimes (5–29%) | In 1 condition |
| DEAF1DEAF1 transcription factor | Sometimes (5–29%) | In 1 condition |
| DPAGT1dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 | Sometimes (5–29%) | In 1 condition |
| GMPPBGDP-mannose pyrophosphorylase B | Sometimes (5–29%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Sometimes (5–29%) | In 1 condition |
| KBTBD13kelch repeat and BTB domain containing 13 | Sometimes (5–29%) | In 1 condition |
| KLHL41kelch like family member 41 | Sometimes (5–29%) | In 2 conditions |
| LAMA2laminin subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| LMOD3leiomodin 3 | Sometimes (5–29%) | In 1 condition |
| MAP3K20mitogen-activated protein kinase kinase kinase 20 | Sometimes (5–29%) | In 1 condition |
| MYH7myosin heavy chain 7 | Sometimes (5–29%) | In 1 condition |
| NEBnebulin | Sometimes (5–29%) | In 3 conditions |
| NOGnoggin | Sometimes (5–29%) | In 1 condition |
| POGZpogo transposable element derived with ZNF domain | Sometimes (5–29%) | In 1 condition |
| SELENONselenoprotein N | Sometimes (5–29%) | In 1 condition |
| SLC34A1solute carrier family 34 member 1 | Sometimes (5–29%) | In 1 condition |
| SLC34A3solute carrier family 34 member 3 | Sometimes (5–29%) | In 1 condition |
| SPG7SPG7 matrix AAA peptidase subunit, paraplegin | Sometimes (5–29%) | In 1 condition |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 3 conditions |
| TPM3tropomyosin 3 | Sometimes (5–29%) | In 1 condition |
| TTI1TELO2 interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| VAPBVAMP associated protein B and C | Sometimes (5–29%) | In 1 condition |
| YY1YY1 transcription factor | Sometimes (5–29%) | In 2 conditions |
| MORC2MORC family CW-type zinc finger 2 | Rarely (1–4%) | In 1 condition |
| ACANaggrecan | Not recorded | In 1 condition |
| ALPLalkaline phosphatase, biomineralization associated | Not recorded | In 1 condition |
| CANT1calcium activated nucleotidase 1 | Not recorded | In 1 condition |
| CHKBcholine kinase beta | Not recorded | In 1 condition |
| DOK7docking protein 7 | Not recorded | In 1 condition |
| FGD4FYVE, RhoGEF and PH domain containing 4 | Not recorded | In 1 condition |
| FLNCfilamin C | Not recorded | In 1 condition |
| FN1fibronectin 1 | Not recorded | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Not recorded | In 1 condition |
| MMP13matrix metallopeptidase 13 | Not recorded | In 2 conditions |
| NEFHneurofilament heavy chain | Not recorded | In 1 condition |
| NEFLneurofilament light chain | Not recorded | In 1 condition |
| PLEKHG5pleckstrin homology and RhoGEF domain containing G5 | Not recorded | In 1 condition |
| POC1APOC1 centriolar protein A | Not recorded | In 1 condition |
| SLC39A13solute carrier family 39 member 13 | Not recorded | In 1 condition |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Not recorded | In 1 condition |
| TGFB2transforming growth factor beta 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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Log InAskGet Startedfrom $449
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks