Trait
Spastic walk
Clinical name: Spastic gait
Spasticity is manifested by increased stretch reflex which is intensified with movement velocity. This results in excessive and inappropriate muscle activation which can contribute to muscle hypertonia. Spastic gait is characterized by manifestations such as muscle hypertonia, stiff knee, and circumduction of the leg.
Reference genomeGRCh38hg38
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Get my Genome Test75 genes linked to Spastic walk
Changes in these genes cause rare conditions in which Spastic walk is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AFG3L2AFG3 like matrix AAA peptidase subunit 2 | Always | In 1 condition |
| ARG1arginase 1 | Always | In 1 condition |
| CCT5chaperonin containing TCP1 subunit 5 | Always | In 1 condition |
| CYP7B1cytochrome P450 family 7 subfamily B member 1 | Always | In 1 condition |
| FDXRferredoxin reductase | Always | In 1 condition |
| FUCA1alpha-L-fucosidase 1 | Always | In 1 condition |
| GJC2gap junction protein gamma 2 | Always | In 1 condition |
| KCNA4potassium voltage-gated channel subfamily A member 4 | Always | In 1 condition |
| KIDINS220kinase D interacting substrate 220 | Always | In 1 condition |
| KIF5Akinesin family member 5A | Always | In 1 condition |
| MAGmyelin associated glycoprotein | Always | In 1 condition |
| NSUN2NOP2/Sun RNA methyltransferase 2 | Always | In 1 condition |
| NT5C25'-nucleotidase, cytosolic II | Always | In 2 conditions |
| REEP1receptor accessory protein 1 | Always | In 2 conditions |
| REEP2receptor accessory protein 2 | Always | In 3 conditions |
| RTN2reticulon 2 | Always | In 3 conditions |
| SACSsacsin molecular chaperone | Always | In 1 condition |
| SPARTspartin | Always | In 2 conditions |
| SPTAN1spectrin alpha, non-erythrocytic 1 | Always | In 2 conditions |
| SPTSSAserine palmitoyltransferase small subunit A | Always | In 1 condition |
| TECPR2tectonin beta-propeller repeat containing 2 | Always | In 1 condition |
| TMEM63Ctransmembrane protein 63C | Always | In 1 condition |
| TUBA4Atubulin alpha 4a | Always | In 1 condition |
| VCPvalosin containing protein | Always | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Very often (80–99%) | In 4 conditions |
| ALS2alsin Rho guanine nucleotide exchange factor ALS2 | Very often (80–99%) | In 3 conditions |
| CPT1Ccarnitine palmitoyltransferase 1C | Very often (80–99%) | In 1 condition |
| ERLIN2ER lipid raft associated 2 | Very often (80–99%) | In 1 condition |
| KCNA1potassium voltage-gated channel subfamily A member 1 | Very often (80–99%) | In 2 conditions |
| KIF1Akinesin family member 1A | Very often (80–99%) | In 2 conditions |
| PLP1proteolipid protein 1 | Very often (80–99%) | In 2 conditions |
| SLC33A1solute carrier family 33 member 1 | Very often (80–99%) | In 2 conditions |
| SPG7SPG7 matrix AAA peptidase subunit, paraplegin | Very often (80–99%) | In 3 conditions |
| ABCD1ATP binding cassette subfamily D member 1 | Often (30–79%) | In 1 condition |
| AP5Z1adaptor related protein complex 5 subunit zeta 1 | Often (30–79%) | In 2 conditions |
| ARSIarylsulfatase family member I | Often (30–79%) | In 1 condition |
| ATAD3AATPase family AAA domain containing 3A | Often (30–79%) | In 1 condition |
| ATL1atlastin GTPase 1 | Often (30–79%) | In 2 conditions |
| BSCL2BSCL2 lipid droplet biogenesis associated, seipin | Often (30–79%) | In 2 conditions |
| CACNA1Gcalcium voltage-gated channel subunit alpha1 G | Often (30–79%) | In 2 conditions |
Show 35 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CYP2U1cytochrome P450 family 2 subfamily U member 1 | Often (30–79%) | In 1 condition |
| DDHD1DDHD domain containing 1 | Often (30–79%) | In 1 condition |
| DDHD2DDHD domain containing 2 | Often (30–79%) | In 1 condition |
| DSTYKdual serine/threonine and tyrosine protein kinase | Often (30–79%) | In 1 condition |
| ERLIN1ER lipid raft associated 1 | Often (30–79%) | In 2 conditions |
| HSPD1heat shock protein family D (Hsp60) member 1 | Often (30–79%) | In 2 conditions |
| PGAP1post-GPI attachment to proteins inositol deacylase 1 | Often (30–79%) | In 1 condition |
| POLR3BRNA polymerase III subunit B | Often (30–79%) | In 1 condition |
| RAB3ARAB3A, member RAS oncogene family | Often (30–79%) | In 1 condition |
| SHMT2serine hydroxymethyltransferase 2 | Often (30–79%) | In 1 condition |
| SLC25A15solute carrier family 25 member 15 | Often (30–79%) | In 2 conditions |
| UBA5ubiquitin like modifier activating enzyme 5 | Often (30–79%) | In 1 condition |
| UBAP1ubiquitin associated protein 1 | Often (30–79%) | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Often (30–79%) | In 1 condition |
| VAMP1vesicle associated membrane protein 1 | Often (30–79%) | In 1 condition |
| WASHC5WASH complex subunit 5 | Often (30–79%) | In 2 conditions |
| WDR48WD repeat domain 48 | Often (30–79%) | In 1 condition |
| ZFRzinc finger RNA binding protein | Often (30–79%) | In 1 condition |
| APCAPC regulator of Wnt signaling pathway | Sometimes (5–29%) | In 1 condition |
| COX18cytochrome c oxidase assembly factor COX18 | Sometimes (5–29%) | In 1 condition |
| KPNA3karyopherin subunit alpha 3 | Sometimes (5–29%) | In 1 condition |
| LMNB1lamin B1 | Sometimes (5–29%) | In 1 condition |
| PLAAT3phospholipase A and acyltransferase 3 | Sometimes (5–29%) | In 1 condition |
| TACO1translational activator of cytochrome c oxidase I | Sometimes (5–29%) | In 1 condition |
| WLSWnt ligand secretion mediator | Sometimes (5–29%) | In 1 condition |
| CTCFCCCTC-binding factor | Rarely (1–4%) | In 1 condition |
| B4GALNT1beta-1,4-N-acetyl-galactosaminyltransferase 1 | Not recorded | In 1 condition |
| GBA2glucosylceramidase beta 2 | Not recorded | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Not recorded | In 1 condition |
| MFSD2AMFSD2 lysolipid transporter A, lysophospholipid | Not recorded | In 1 condition |
| NIPA1NIPA magnesium transporter 1 | Not recorded | In 1 condition |
| SPASTspastin | Not recorded | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Not recorded | In 1 condition |
| WDR26WD repeat domain 26 | Not recorded | In 1 condition |
| ZFYVE26zinc finger FYVE-type containing 26 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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