Trait
Prominent swayback
Clinical name: Hyperlordosis
Abnormally increased curvature (anterior concavity) of the lumbar or cervical spine.
Summary
- Also called
- Lordosis
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Prominent swayback, and the rest of your genome, with one test.
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Get my Genome Test157 genes linked to Prominent swayback
Changes in these genes cause rare conditions in which Prominent swayback is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CANT1calcium activated nucleotidase 1 | Always | In 1 condition |
| ECEL1endothelin converting enzyme like 1 | Always | In 1 condition |
| GNB2G protein subunit beta 2 | Always | In 1 condition |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Always | In 1 condition |
| GNPTGN-acetylglucosamine-1-phosphate transferase subunit gamma | Always | In 1 condition |
| HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | Always | In 1 condition |
| LBRlamin B receptor | Always | In 1 condition |
| MEGF10multiple EGF like domains 10 | Always | In 1 condition |
| POMGNT1protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | Always | In 1 condition |
| RAB33BRAB33B, member RAS oncogene family | Always | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Always | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Always | In 2 conditions |
| TAF4TATA-box binding protein associated factor 4 | Always | In 1 condition |
| DNMT3BDNA methyltransferase 3 beta | Very often (80–99%) | In 1 condition |
| DUX4double homeobox 4 | Very often (80–99%) | In 1 condition |
| DUX4L1double homeobox 4 like 1 (pseudogene) | Very often (80–99%) | In 1 condition |
| FRG1FSHD region gene 1 | Very often (80–99%) | In 1 condition |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Very often (80–99%) | In 1 condition |
| HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B1 | Very often (80–99%) | In 1 condition |
| KIF1Akinesin family member 1A | Very often (80–99%) | In 1 condition |
| MMP13matrix metallopeptidase 13 | Very often (80–99%) | In 1 condition |
| OBSL1obscurin like cytoskeletal adaptor 1 | Very often (80–99%) | In 2 conditions |
| RETREG1reticulophagy regulator 1 | Very often (80–99%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Very often (80–99%) | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Very often (80–99%) | In 1 condition |
| SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1 | Very often (80–99%) | In 1 condition |
| VCPvalosin containing protein | Very often (80–99%) | In 1 condition |
| WNK1WNK lysine deficient protein kinase 1 | Very often (80–99%) | In 1 condition |
| ACTA1actin alpha 1, skeletal muscle | Often (30–79%) | In 5 conditions |
| ARSKarylsulfatase family member K | Often (30–79%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Often (30–79%) | In 1 condition |
| BICD2BICD cargo adaptor 2 | Often (30–79%) | In 2 conditions |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Often (30–79%) | In 1 condition |
| CAPN3calpain 3 | Often (30–79%) | In 2 conditions |
| CCDC8coiled-coil domain containing 8 subunit of 3M complex | Often (30–79%) | In 2 conditions |
| CLIP2CAP-Gly domain containing linker protein 2 | Often (30–79%) | In 1 condition |
| COLEC10collectin subfamily member 10 | Often (30–79%) | In 1 condition |
| COLEC11collectin subfamily member 11 | Often (30–79%) | In 1 condition |
| CSGALNACT1chondroitin sulfate N-acetylgalactosaminyltransferase 1 | Often (30–79%) | In 1 condition |
| CUL7cullin 7 | Often (30–79%) | In 2 conditions |
Show 117 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| DNA2DNA replication helicase/nuclease 2 | Often (30–79%) | In 2 conditions |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Often (30–79%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Often (30–79%) | In 1 condition |
| ELNelastin | Often (30–79%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Often (30–79%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Often (30–79%) | In 2 conditions |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Often (30–79%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Often (30–79%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Often (30–79%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Often (30–79%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Often (30–79%) | In 1 condition |
| IHHIndian hedgehog signaling molecule | Often (30–79%) | In 1 condition |
| KNSTRNkinetochore localized astrin (SPAG5) binding protein | Often (30–79%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Often (30–79%) | In 1 condition |
| LMNAlamin A/C | Often (30–79%) | In 4 conditions |
| MAP3K20mitogen-activated protein kinase kinase kinase 20 | Often (30–79%) | In 2 conditions |
| MASP1MBL associated serine protease 1 | Often (30–79%) | In 1 condition |
| METTL27methyltransferase like 27 | Often (30–79%) | In 1 condition |
| MUSKmuscle associated receptor tyrosine kinase | Often (30–79%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Often (30–79%) | In 1 condition |
| NPR2natriuretic peptide receptor 2 | Often (30–79%) | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Often (30–79%) | In 1 condition |
| PPM1Dprotein phosphatase, Mg2+/Mn2+ dependent 1D | Often (30–79%) | In 1 condition |
| PUS1pseudouridine synthase 1 | Often (30–79%) | In 1 condition |
| RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1 | Often (30–79%) | In 1 condition |
| RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2 | Often (30–79%) | In 1 condition |
| RFC2replication factor C subunit 2 | Often (30–79%) | In 1 condition |
| RSPRY1ring finger and SPRY domain containing 1 | Often (30–79%) | In 1 condition |
| SELENONselenoprotein N | Often (30–79%) | In 2 conditions |
| SGCAsarcoglycan alpha | Often (30–79%) | In 1 condition |
| SNUPNsnurportin 1 | Often (30–79%) | In 1 condition |
| SPTLC1serine palmitoyltransferase long chain base subunit 1 | Often (30–79%) | In 1 condition |
| STX1Asyntaxin 1A | Often (30–79%) | In 1 condition |
| TBL2transducin beta like 2 | Often (30–79%) | In 1 condition |
| TBX6T-box transcription factor 6 | Often (30–79%) | In 1 condition |
| TFE3transcription factor binding to IGHM enhancer 3 | Often (30–79%) | In 1 condition |
| TMEM270transmembrane protein 270 | Often (30–79%) | In 1 condition |
| TRAPPC11trafficking protein particle complex subunit 11 | Often (30–79%) | In 2 conditions |
| TRPS1transcriptional repressor GATA binding 1 | Often (30–79%) | In 2 conditions |
| TWIST1twist family bHLH transcription factor 1 | Often (30–79%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Often (30–79%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 1 condition |
| ALG2ALG2 alpha-1,3/1,6-mannosyltransferase | Sometimes (5–29%) | In 1 condition |
| AMER1APC membrane recruitment protein 1 | Sometimes (5–29%) | In 1 condition |
| ASCC3activating signal cointegrator 1 complex subunit 3 | Sometimes (5–29%) | In 1 condition |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 1 condition |
| BCRBCR activator of RhoGEF and GTPase | Sometimes (5–29%) | In 1 condition |
| BIN1bridging integrator 1 | Sometimes (5–29%) | In 2 conditions |
| CAVIN1caveolae associated protein 1 | Sometimes (5–29%) | In 1 condition |
| CCN6cellular communication network factor 6 | Sometimes (5–29%) | In 1 condition |
| CFL2cofilin 2 | Sometimes (5–29%) | In 1 condition |
| COL12A1collagen type XII alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| CRKLCRK like proto-oncogene, adaptor protein | Sometimes (5–29%) | In 1 condition |
| CTNNB1catenin beta 1 | Sometimes (5–29%) | In 1 condition |
| DDRGK1DDRGK domain containing 1 | Sometimes (5–29%) | In 1 condition |
| DYSFdysferlin | Sometimes (5–29%) | In 1 condition |
| EMDemerin | Sometimes (5–29%) | In 1 condition |
| FEM1Bfem-1 homolog B | Sometimes (5–29%) | In 1 condition |
| FHL1four and a half LIM domains 1 | Sometimes (5–29%) | In 2 conditions |
| H4C5H4 clustered histone 5 | Sometimes (5–29%) | In 1 condition |
| HACD13-hydroxyacyl-CoA dehydratase 1 | Sometimes (5–29%) | In 1 condition |
| HNRNPH2heterogeneous nuclear ribonucleoprotein H2 | Sometimes (5–29%) | In 1 condition |
| ITGA7integrin subunit alpha 7 | Sometimes (5–29%) | In 1 condition |
| KDM6Blysine demethylase 6B | Sometimes (5–29%) | In 1 condition |
| KLHL41kelch like family member 41 | Sometimes (5–29%) | In 1 condition |
| LAMA2laminin subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| LMOD3leiomodin 3 | Sometimes (5–29%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Sometimes (5–29%) | In 1 condition |
| MYL2myosin light chain 2 | Sometimes (5–29%) | In 1 condition |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Sometimes (5–29%) | In 1 condition |
| NEBnebulin | Sometimes (5–29%) | In 2 conditions |
| NECTIN1nectin cell adhesion molecule 1 | Sometimes (5–29%) | In 1 condition |
| NOTCH3notch receptor 3 | Sometimes (5–29%) | In 1 condition |
| PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha | Sometimes (5–29%) | In 1 condition |
| PLAAT3phospholipase A and acyltransferase 3 | Sometimes (5–29%) | In 1 condition |
| PPP1R15Bprotein phosphatase 1 regulatory subunit 15B | Sometimes (5–29%) | In 1 condition |
| RTN2reticulon 2 | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 1 condition |
| SETBP1SET binding protein 1 | Sometimes (5–29%) | In 1 condition |
| SETD5SET domain containing 5 | Sometimes (5–29%) | In 1 condition |
| SPEGstriated muscle enriched protein kinase | Sometimes (5–29%) | In 1 condition |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Sometimes (5–29%) | In 1 condition |
| SYNE2spectrin repeat containing nuclear envelope protein 2 | Sometimes (5–29%) | In 1 condition |
| TGFB1transforming growth factor beta 1 | Sometimes (5–29%) | In 1 condition |
| TMEM43transmembrane protein 43 | Sometimes (5–29%) | In 1 condition |
| TNNT1troponin T1, slow skeletal type | Sometimes (5–29%) | In 1 condition |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 2 conditions |
| TPM3tropomyosin 3 | Sometimes (5–29%) | In 1 condition |
| TTNtitin | Sometimes (5–29%) | In 1 condition |
| CTSKcathepsin K | Rarely (1–4%) | In 1 condition |
| NF1neurofibromin 1 | Rarely (1–4%) | In 1 condition |
| COL1A2collagen type I alpha 2 chain | Not recorded | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Not recorded | In 1 condition |
| COLQcollagen like tail subunit of asymmetric acetylcholinesterase | Not recorded | In 1 condition |
| DMDdystrophin | Not recorded | In 1 condition |
| DNM2dynamin 2 | Not recorded | In 1 condition |
| EIF2AK3eukaryotic translation initiation factor 2 alpha kinase 3 | Not recorded | In 1 condition |
| FKRPfukutin related protein | Not recorded | In 2 conditions |
| FKTNfukutin | Not recorded | In 1 condition |
| FLNBfilamin B | Not recorded | In 1 condition |
| GALNSgalactosamine (N-acetyl)-6-sulfatase | Not recorded | In 1 condition |
| GLB1galactosidase beta 1 | Not recorded | In 1 condition |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Not recorded | In 1 condition |
| INPP5Kinositol polyphosphate-5-phosphatase K | Not recorded | In 1 condition |
| L1CAML1 cell adhesion molecule | Not recorded | In 1 condition |
| MTMR14myotubularin related protein 14 | Not recorded | In 1 condition |
| NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL | Not recorded | In 1 condition |
| PLEKHG5pleckstrin homology and RhoGEF domain containing G5 | Not recorded | In 1 condition |
| POMT2protein O-mannosyltransferase 2 | Not recorded | In 1 condition |
| POP1POP1 ribonuclease P/MRP subunit | Not recorded | In 1 condition |
| RETret proto-oncogene | Not recorded | In 1 condition |
| SGCGsarcoglycan gamma | Not recorded | In 1 condition |
| SLC10A7solute carrier family 10 member 7 | Not recorded | In 1 condition |
| TFAP2Atranscription factor AP-2 alpha | Not recorded | In 1 condition |
| TOR1Atorsin family 1 member A | Not recorded | In 1 condition |
| TRPV4transient receptor potential cation channel subfamily V member 4 | Not recorded | In 2 conditions |
| ZC4H2zinc finger C4H2-type containing | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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